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Biodegradable and absorbable magnesium-zinc-copper alloy with antibiotic function, and application thereof

A technology of copper alloy and magnesium alloy, which is applied in the fields of coating, medical science, surgery, etc., can solve the problems of increasing the fracture and delamination of coatings and implants, the inability to achieve infection prevention and treatment, and the inability to solve the problem of antibiotic resistance, etc. Achieve satisfactory degradability, prevention and treatment of surrounding infection, and good application value

Inactive Publication Date: 2015-05-06
SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are two main research directions for this kind of antibacterial materials: 1) Use porous materials as carriers to load antibiotics, and use the materials as drug-loaded sustained-release systems for local treatment, but these materials still cannot solve the increasing number of multi-resistant drugs. Drug resistance of pathogenic bacteria to antibiotics
2) The surface of the inplant material is covered with an antibacterial coating containing antibacterial metal ions. The metal ions can be broad-spectrum antibacterial and have a good antibacterial effect. However, due to the thin thickness of the antibacterial coating, the degradation speed is fast and the action time is short. It is impossible to prevent and treat infection for a long time after surgery, and the bonding force between the coating and the implant material interface is often insufficient, which increases the hidden danger of fracture and delamination between the coating and the implant

Method used

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  • Biodegradable and absorbable magnesium-zinc-copper alloy with antibiotic function, and application thereof
  • Biodegradable and absorbable magnesium-zinc-copper alloy with antibiotic function, and application thereof

Examples

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Embodiment 1

[0039] This embodiment provides a degradable and absorbable magnesium-zinc-copper alloy for medical use. The components of the magnesium-zinc-copper alloy include magnesium, copper and zinc. In terms of weight percentage, the magnesium-zinc-copper alloy contains copper ≤ 3wt% (such as 0.25wt%, 0.5wt%, 1wt%, 2wt%, 3wt%), zinc (Zn) ≤ 6wt% (such as 0.5wt%, 1wt%) %, 2.5wt%, 4wt%, 5wt% or 6wt%), the balance is magnesium.

Embodiment 2

[0041]This embodiment provides a medical degradable and absorbable magnesium-zinc-copper alloy. The components of the magnesium-zinc-copper alloy include magnesium, zinc, copper, and trace elements, and the trace elements are neodymium. Magnesium-zinc-copper alloy contains copper ≤ 3wt% (such as 0.25wt%, 0.5wt%, 1wt%, 2wt%, 3wt%), zinc (Zn) ≤ 4wt% (such as 0.25wt%, 0.5wt%, 1wt%, 2wt%) % or 4wt%), neodymium (Nd) ≤ 2wt% (such as 0.15wt%, 0.5wt%, 1wt%, or 2wt%), and the balance is magnesium.

Embodiment 3

[0043] This embodiment provides a medical degradable and absorbable magnesium-zinc-copper alloy. The magnesium-zinc-copper alloy contains 0.1wt% copper, 1.5wt% zinc and the balance magnesium, using high-purity raw materials and high-cleanliness smelting technology to manufacture.

[0044] After testing, the magnesium-zinc-copper alloy provided in this embodiment has a tensile strength of 190 MPa and an elongation of 20%.

[0045] The biological evaluation of the magnesium-zinc-copper alloy provided in this example was carried out according to the experimental method described in GB / T16886. Experimental results show that the magnesium-zinc-copper alloy provided in this example has no obvious cytotoxicity and blood coagulation on osteoblasts and bone marrow mesenchymal stem cells, and has no obvious sensitization, stimulation and genotoxicity.

[0046] The magnesium-zinc-copper alloy provided in this embodiment is further processed into a magnesium-zinc-copper alloy intramedull...

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Abstract

The invention provides a magnesium-zinc-copper alloy. The magnesium-zinc-copper alloy comprises 1-8wt% of zinc, 3wt% or less of copper, and the balance of magnesium. The magnesium-zinc-copper alloy has good biocompatibility, satisfactory degradability, high biological safety and extremely good biomechanical performances, can continuously slowly release metal ions having an antibiotic effect to surrounding tissues through in vivo degradation in order to effectively prevent and treat implant surrounding infection, has certain hematopoietic activity, and has good application values in implanting into bones and other medical fields.

Description

technical field [0001] The invention relates to an alloy material, in particular to a body fluid-degradable magnesium-zinc-copper alloy with an antibacterial function that can be used as a medical implant material and an application thereof. Background technique [0002] Medical metal materials have become commonly used internal fixation materials in orthopedics because of their excellent processing and forming properties and corrosion resistance, and are being widely used in clinical practice. However, current medical metal materials such as stainless steel and titanium alloys are all biologically inert materials. After implantation, they remain in the body as foreign bodies for a long time, which will cause different degrees of tissue reactions. It is now believed that the wear particles produced by metal materials in the body not only easily trigger the inflammatory reaction around the material and cause the occurrence of related diseases, but also may cause bone resorpti...

Claims

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Application Information

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IPC IPC(8): C22C23/00C22C23/04C22C23/06A61L31/02A61L31/10A61L31/08A61L31/14A61L31/16
Inventor 曲新华戴尅戎
Owner SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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