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Hyaluronic acid-nano silver-based dressing and preparation method thereof

A technology of hyaluronic acid and nano-silver, applied in medical science, textiles and papermaking, bandages, etc., can solve the problems of limited application scope, no ability to treat and repair wounds, no antibacterial activity, etc. Healing, promoting wound coagulation effect

Active Publication Date: 2015-04-29
王福亮
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, from a medical point of view, these traditional wound dressings have limited clinical application because they do not have the properties of treating and repairing wounds, nor do they have antibacterial activity.

Method used

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  • Hyaluronic acid-nano silver-based dressing and preparation method thereof
  • Hyaluronic acid-nano silver-based dressing and preparation method thereof
  • Hyaluronic acid-nano silver-based dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] （ 1 ) hyaluronic acid - Preparation of nano silver solution: The molecular weight Mw=1×10 6 The hyaluronic acid of g / mol is directly dissolved in deionized water, and the mass concentration of hyaluronic acid is 0.5%, and the silver nitrate solid that accounts for 2% of the hyaluronic acid amount is added in the hyaluronic acid aqueous solution, and magnetic stirring is dissolved; The solution was irradiated under an ultraviolet lamp for 5 minutes to obtain a homogeneous hyaluronic acid-nanometer silver solution;

[0023] （ 2 ) Preparation of drug-containing synthetic polymer solution: Dissolve synthetic polymer polyoxyethylene in water to make a solution with a mass percentage of 5%, and stir it to dissolve; then add 0.1% of the solution amount of therapeutic drug erythromycin, and then fully stir the solution so that it is completely dissolved. That is, the drug-containing polyoxyethylene solution is obtained;

[0024] （ 3 ) Preparation of mixed soluti...

Embodiment 2

[0027] （ 1 ) hyaluronic acid - Preparation of nano silver solution: The molecular weight Mw=1×10 6 The hyaluronic acid of g / mol is directly dissolved in deionized water, and the mass concentration of hyaluronic acid is 1%, and the silver nitrate solid that accounts for 2% of hyaluronic acid amount is added in the hyaluronic acid aqueous solution, and magnetic stirring is dissolved; The solution was irradiated under an ultraviolet lamp for 10 minutes to obtain a homogeneous hyaluronic acid-nanometer silver solution;

[0028] （ 2 ) Preparation of drug-containing synthetic polymer solution: Dissolve the synthetic macromolecular polyvinylpyrrolidone in water to make a solution with a mass percentage of 5%, and magnetically stir to dissolve; then add erythromycin, a therapeutic drug accounting for 0.1% of the solution, and then fully stir the solution so that it is completely dissolved, that is, Obtain drug-containing polyvinylpyrrolidone solution;

[0029] （ 3 ) P...

Embodiment 3

[0032] （ 1 ) hyaluronic acid - Preparation of nano silver solution: The molecular weight Mw=2×10 6 The hyaluronic acid of g / mol is directly dissolved in deionized water, and the mass concentration of hyaluronic acid is 0.5%, and silver nitrate solid accounting for 3% of the hyaluronic acid amount is added in the hyaluronic acid aqueous solution, and magnetic stirring is dissolved; The solution was irradiated under an ultraviolet lamp for 5 minutes to obtain a homogeneous hyaluronic acid-nanometer silver solution;

[0033] （ 2 ) Preparation of drug-containing synthetic polymer solution:Dissolve synthetic macromolecule polyethylene glycol in water to make a solution with a mass percentage of 5%, and stir it to dissolve; then add 0.1% of the solution amount of therapeutic drug tetracycline, and then fully stir the solution so that it is completely dissolved to obtain Drug-containing polyethylene glycol solution;

[0034] （ 3 ) Preparation of mixed solution: Mix t...

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Abstract

The invention relates to a hyaluronic acid-nano silver-based dressing and a preparation method thereof. The hyaluronic acid-nano silver-based dressing comprises therapeutic drugs, nano silver, hyaluronic acid and degradable synthetic high polymers. The method mainly utilizes an electrostatic spinning technique to proportionally mix a solution containing nano silver and hyaluronic acid with a solution containing therapeutic drugs and synthetic high polymers and process the nano fiber nonwoven fabric. The obtained hyaluronic acid-nano silver-based dressing has the characteristics of favorable uniformity, high porosity, favorable air permeability and favorable biocompatibility. In the hyaluronic acid-nano silver-based dressing preparation process, water is used as the solvent, so no organic solvent residue exists. The method has the advantage of simple technique and low cost. The prepared hyaluronic acid-nano silver-based dressing has wide application range, and can be used for various surgical cuts, burn and scald surfaces, various traumatic wound surfaces, peripheral ulcer surfaces and various non-healing chronic ulcer wound surfaces.

Description

Technical field [0001] The invention involves a hyaluronic acid-nano-silver-based dressing and its preparation methods, which belongs to a field of preparation of biomedical dressing. technical background [0002] Static spinning technology is the most effective way to prepare ultra -fine nano -fiber non -woven fabrics. The prepared nanofiber non -woven fabrics have larger surface area, high pore rate, fineness and average one -level one, long diameter and large ratio, etc.advantage.It has important applications in the fields of biomedical organizations. [0003] The skin is an important organ of the human body, and it is a bridge for natural barriers and communication between the body and the outside world.Due to burns, trauma, and skin ulcers, skin tissue defects may lead to wound infection.At present, an effective way to deal with skin wounds is to use wound dressings.Traditional wound dressings include gauze, dehydrated cotton, bandage, etc.However, from a medical perspective...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/26A61L15/24A61L15/44D04H1/728
Inventor 王福亮
Owner 王福亮
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