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Hedyotis diffusa extract used for preventing and treating senile dementia and preparation method of hedyotis diffusa extract

A technology of Hedyotis diffusa and senility, applied in the direction of medical preparations containing active ingredients, drug combinations, and pharmaceutical formulas, can solve problems such as complex chemical components, achieve uniform quality, content control, and facilitate standardization

Inactive Publication Date: 2015-04-29
SHANDONG ACADEMY OF PHARMACEUTICAL SCIENCES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0016] Due to the complex chemical composition in Hedyotis diffusa, and the instability of iridoids, so far, there has been no experience that gallizine and its derivatives extracted from the above plants have the effects of intelligence and memory enhancement. Can be used to prevent and treat senile dementia report

Method used

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  • Hedyotis diffusa extract used for preventing and treating senile dementia and preparation method of hedyotis diffusa extract
  • Hedyotis diffusa extract used for preventing and treating senile dementia and preparation method of hedyotis diffusa extract
  • Hedyotis diffusa extract used for preventing and treating senile dementia and preparation method of hedyotis diffusa extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] 1. Extraction: 1kg of the traditional Chinese medicine Hedyotis diffusa, coarsely crushed and soaked in water for 3 times, the water consumption for each time is 12 times of the dry weight of Hedyotis diffusa, soaked for 24 hours each time. Combine the extracts, concentrate under reduced pressure to a thick extract, add distilled water to heat and dissolve, cool to room temperature, let stand for 24 hours, and filter to obtain a clear filtrate.

[0045] 2. Alcohol precipitation and refining: extract the concentrated solution of Hedyotis diffusa with water, add ethanol (95%) under full stirring, so that the alcohol content of the solution is 70%, let it stand for 24 hours, filter, collect the filtrate, and then recover under reduced pressure Ethanol to liquid extract.

[0046] 3. Macroporous resin adsorption chromatographic refinement: dissolve the liquid extract in 2 with water and filter, pass the filtrate through the treated HP-20 macroporous adsorption resin, mix wit...

Embodiment 2

[0048] 1. Extraction: Chinese medicine Hedyotis diffusa 1kg, coarsely crushed and decocted twice with water, each time the water consumption is 12 times of the dry weight of Hedyotis diffusa, the decoction temperature is 98°C, and the decoction time is 1 hour. Combine the extracts, filter, and concentrate the filtrate under reduced pressure to a thick extract, add distilled water to heat and dissolve, cool to room temperature, let stand for 24 hours, and filter to obtain a clear filtrate.

[0049] 2. Alcohol precipitation and refining: extract the concentrated solution of Hedyotis diffusa with water, add ethanol (95%) under full stirring, so that the alcohol content of the solution is 75%, let it stand for 16 hours, filter, collect the filtrate, and then recover under reduced pressure Ethanol to liquid extract.

[0050] 3. Purification by macroporous resin adsorption chromatography: dissolve the liquid extract in 2 with water and filter, pass the filtrate through the treated ...

Embodiment 3

[0052] 1. Extraction: Chinese medicine Hedyotis diffusa 1kg, coarsely crushed and then soaked in water for 2 extractions, each time the water consumption is 12 times of the dry weight of Hedyotis diffusa, soaked for 18 hours each time, combined extracts, filtered, filtrate Concentrate under reduced pressure to a thick extract, add distilled water to heat and dissolve, cool to room temperature, let stand for 18 hours, and filter to obtain a clear filtrate.

[0053] 2. Alcohol precipitation and refining: extract the concentrated solution of Hedyotis diffusa with water, add ethanol (95%) under full stirring, so that the alcohol content of the solution is 75%, let it stand for 24 hours, filter, collect the filtrate, and then recover under reduced pressure Ethanol to liquid extract.

[0054] 3. Purification by macroporous resin adsorption chromatography: dissolve the liquid extract in 2 with water and filter, pass the filtrate through the treated styrene RH type macroporous adsorpt...

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Abstract

The invention relates to application of hedyotis diffusa plant extract containing a secondary paederia scandens glucoside derivative in preparation of a medicine used for reinforcing intelligence and preventing and treating diseases such as senile dementia. The invention also relates to a preparation method of extracting and refining plant extract from hedyotis diffusa wild, wherein an active ingredient is the secondary paederia scandens glucoside derivative; water or alcohol is adopted for extraction, the extract is refined by adopting a precipitation and chromatographic process, and the extract can be further purified by adopting gel column choromatography if necessary, so that the plant extract with the secondary paederia scandens glucoside derivative content of 25% and especially more than 50% is obtained. Optimal dosage forms of the medicine comprise injection, tablets, capsules, soft capsules, oral liquid, dropping pills and the like.

Description

technical field [0001] The invention belongs to the technical field of natural medicines. Specifically relate to a kind of Hedyotis diffusa Willd. (Hedyotis diffusa Willd.) plant extract that contains gallinaceous vine glycoside (scandoside) and derivative thereof, i.e. iridoid glycoside compound, or be called total iridoid glycoside The use in the preparation of drugs for improving intelligence, enhancing memory or preventing and treating diseases such as senile dementia. The plant extract extracted and refined from the traditional Chinese medicine Hedyotis diffusa and its extraction method. Background technique [0002] Senile dementia, also known as Alzheimer's Disease (Alzheimer's Disease, referred to as AD), is a chronic dysfunction of the brain's high-level polymerization process. Due to the hidden onset, the early symptoms are easy to be ignored. With the acceleration of the aging population in our country, the number of patients with senile dementia is increasing d...

Claims

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Application Information

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IPC IPC(8): A61K36/748A61K31/7048A61P25/28
Inventor 王芳郭琪张岱州马河粱大连曹冲
Owner SHANDONG ACADEMY OF PHARMACEUTICAL SCIENCES
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