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Preparation method of stable nano ferroferric oxide magnetofluid

A magnetic and nanotechnology of ferroferric oxide, which is applied in the direction of nanomagnetism, ferrous oxide, iron oxide/iron hydroxide, etc., can solve the problem of wide particle size distribution of nano ferroferric oxide and the stability of magnetic fluid aqueous solution low price, good crystal form, and high repeatability

Inactive Publication Date: 2015-04-22
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Ferroferric oxide nanoparticles can be directly produced in aqueous solution by co-precipitation method, but the nanometer ferroferric oxide obtained by this method usually has a wide particle size distribution, poor crystallinity, and the stability of the formed magnetic fluid aqueous solution is not high.
However, the particle size distribution of the ferroferric oxide obtained through the organic phase is narrow and the crystal form is relatively high, but if you want it to be used as a magnetic resonance contrast agent, the biocompatibility is not good, and it needs to go through a phase transfer process, which is relatively complicated and time consuming

Method used

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  • Preparation method of stable nano ferroferric oxide magnetofluid
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  • Preparation method of stable nano ferroferric oxide magnetofluid

Examples

Experimental program
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Effect test

Embodiment 1

[0027] The preparation of iron ferric oxide nanoparticles specifically comprises the following steps:

[0028] (a) Take 1 mL of ferric salt stock solution (4.5 M), add it to a 250 mL three-necked bottle, and dilute with distilled water;

[0029] (b) Take a certain amount of reductant vitamin C and EDTA disodium salt stock solution, add it to the ferric iron solution, control the ratio of reductant to ferric salt to 1:3, control EDTA The ratio of disodium acetate to ferric iron is 2:1;

[0030] (c) adjust the pH value to 11 with 1M sodium hydroxide solution;

[0031] (d) Introduce high-purity nitrogen gas into the solution for 30 minutes to remove the oxygen in the solution, so that the reaction proceeds under anaerobic conditions; heat to 70°C and reflux for 2 hours. In this example, the reaction solution turns black to prove that the obtained four Ferric oxide solution, if the solution is brown or reddish brown, it means that there is a part of ferric oxide in the solution....

Embodiment 2

[0036] The preparation of iron ferric oxide nanoparticles specifically comprises the following steps:

[0037](a) Take 1 mL of ferric salt stock solution (0.45 M), add it to a 250 mL three-necked bottle, and dilute with distilled water;

[0038] (b) Take a certain amount of reductant vitamin C and EDTA disodium salt stock solution, add it to the ferric iron solution, control the ratio of reductant to ferric salt to 1:3, control EDTA The ratio of disodium acetate to ferric iron is 2:1;

[0039] (c) adjust the pH value to 11 with 1M sodium hydroxide solution;

[0040] (d) Introduce high-purity nitrogen gas into the solution for 30 minutes to remove the oxygen in the solution, so that the reaction proceeds under anaerobic conditions; heat to 70°C and reflux for 2 hours. In this example, the reaction solution turns black to prove that the obtained four Ferric oxide solution, if the solution is brown or reddish brown, it means that there is a part of ferric oxide in the solution....

Embodiment 3

[0044] The preparation of iron ferric oxide nanoparticles specifically comprises the following steps:

[0045] (a) Take 1 mL of ferric salt stock solution (0.45 M), add it to a 250 mL three-necked bottle, and dilute with distilled water;

[0046] (b) Take a certain amount of stock solution of reducing agent hydrazine hydrate and 20kD dextran, add it to the ferric iron solution, control the ratio of reducing agent to ferric salt to 1:3.75, and control the amount of dextran to be 15 to 20g;

[0047] (c) adjust the pH value to 11.2 with 1M sodium hydroxide solution;

[0048] (d) Introduce high-purity nitrogen gas into the solution for 30 minutes to remove oxygen in the solution, so that the reaction proceeds under anaerobic conditions; heat to 70°C and reflux for 2 hours. In this case, the reaction solution turns black to prove that the tetraoxide is obtained Iron trioxide solution, if the solution is brown or reddish brown, it means that there is a part of ferric oxide in the ...

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Abstract

The invention belongs to the technical field of the preparation of iron oxide magnetofluids and particularly relates to an aqueous reduction based synthesis method of superparamagnetic ferroferric oxide nanoparticles. According to the aqueous reduction based synthesis method, an inorganic metal water-soluble compound (ferric salt) serves as an iron source, a reducing compound and a stabilizer which can be coordinated with iron serve as raw materials, and reduction reaction is carried out in an aqueous solution to generate the ferroferric oxide magnetofluid in situ. The aqueous reduction based synthesis method provided by the invention has the advantages of mild reaction condition and good repeatability, is easy to operate and safe, and the ferroferric oxide nanoparticles prepared by adopting the aqueous reduction based synthesis method overcome the defects that the ferroferric oxide particles prepared by adopting the traditional aqueous co-precipitation method are easy to agglomerate, can not be dispersed uniformly and are affected in application. The ferroferric oxide nanoparticles with stable performance are prepared successfully by adopting the aqueous reduction based synthesis method, and the ferroferric oxide nanoparticles have good biocompatibility, can form the magnetofluid in an aqueous solution and can be widely applied to the biomedical fields of magnetic resonance imaging, magnetofluid thermotherapy, cell separation, protein separation, DNA purification, immunodetection, magnetically targeted medicine carriers.

Description

technical field [0001] The invention belongs to the technical field of preparation of nano ferroferrofluid, and in particular relates to a reduction preparation method of a stable ferroferrofluid. Background technique [0002] With the rapid development of science and technology, people's cognition field has continuously developed from the macrocosm to the microcosm, and then gradually formed a new research direction of nanoscience. Nano science and technology is a science and technology that studies the structure, change law and technical problems in possible practical applications of substances with a particle size between 1-100 nm. Magnetic nanoparticle is a new type of material that appeared in the 1980s. It has attracted more and more attention in the fields of cell sorting and labeling, protein separation and purification, drug delivery, and magnetic resonance imaging, and has become a research hotspot in recent years. The stable colloid system formed by nano-scale ma...

Claims

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Application Information

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IPC IPC(8): C01G49/08H01F1/44B82Y30/00B82Y25/00
Inventor 张景海王超邵言
Owner SHENYANG PHARMA UNIVERSITY
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