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Orally disintegrating tablet containing fresh ginseng active extract and preparation method thereof

A technology of extract and fresh ginseng, which is applied in the field of orally disintegrating active extract of fresh ginseng and its preparation, can solve the problems of low bioavailability and inconvenient consumption, and achieve high extraction rate, simple preparation method and low energy consumption. low effect

Active Publication Date: 2015-04-22
通化鑫业生物科技研发有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] At present, ginseng, American ginseng and their products sold in the market generally have the problems of inconvenient consumption and low bioavailability. Therefore, the development of a high-activity ginseng extract orally disintegrating tablet product can improve the utilization value of ginseng and meet the needs of some people at the same time. needs, has great practical significance

Method used

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  • Orally disintegrating tablet containing fresh ginseng active extract and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Embodiment 1 preparation of fresh ginseng active extract

[0028] Take 10 kg of fresh ginseng under the forest, clean it with distilled water, crush it into 60-100 mesh particles, and use continuous countercurrent ultrasonic extraction equipment to extract under the condition of 25-35 ° C, using water as the extraction solvent, and the extract is centrifuged. Concentrate through a reverse osmosis concentrator (Hefei Zhixuan Membrane Separation Technology Co., Ltd.) to obtain a concentrate and reverse osmosis water. Reverse osmosis water is recycled as extraction solvent to realize green production. The concentrated solution is freeze-dried to obtain the active extract of fresh ginseng, and the active extract has a weight of 1.02 kg and is a brownish-yellow powder.

[0029] After testing, the content of ginsenoside Rg1 in the ginseng active extract is 3.15%, the content of ginsenoside Re is 2.2%, and the content of ginsenoside Rb1 is 2.7%. The extraction rate of ginsen...

Embodiment 2

[0030] Embodiment 2 preparation of fresh ginseng active extract

[0031] Take 50 kg of fresh ginseng under the forest, clean it with distilled water, crush it into 60-100 mesh particles, and use continuous countercurrent ultrasonic extraction equipment to extract at 25-35°C, with 10% ethanol-water as the extraction After the solvent and the extract are centrifuged, they are concentrated by a reverse osmosis concentrator (Hefei Zhixuan Membrane Separation Technology Co., Ltd.) to obtain a concentrate and reverse osmosis water. Reverse osmosis water is recycled as an extraction solvent to achieve green production. The concentrated solution is freeze-dried to obtain the active extract of fresh ginseng, and the active extract weighs 5.1 kg and is a brownish-yellow powder.

[0032] After testing, the content of ginsenoside Rg1 in the ginseng active extract was 3.11%, the content of ginsenoside Re was 2.18%, and the content of ginsenoside Rb1 was 2.61%. The extraction rate of gins...

Embodiment 3

[0033] Embodiment 3 preparation of cross-linked carboxymethyl konjac starch sodium

[0034] Add 2500g of konjac starch to 5000mL of ethanol with a volume fraction of 95%, fully stir and disperse evenly to form a starch emulsion, add 1200g of NaOH solid alkalization, and add a cross-linking agent epichlorohydrin with a starch mass of 0.12% at the same time, and place it in a 10L Erlenmeyer flask , install the reflux condenser. Pretreat at 35°C for about 20 minutes, then put in 1200g of chloroacetic acid for carboxymethylation, finish the reaction at 55°C for 2.5h, neutralize and filter while hot, and wash the obtained filter cake with ethanol with a volume fraction of 95%. Then vacuum-dried at 50°C to obtain cross-linked carboxymethyl konjac starch.

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Abstract

The invention belongs to the technical field of deep ginseng processing and in particular relates to an orally disintegrating tablet containing fresh ginseng active extract and a preparation method thereof. The formula of the orally disintegrating tablets comprises the following components in percentage by weight: 50-60 percent of a fresh ginseng active extract, 20-40 percent of a filling agent, 8-15 percent of a disintegrating agent, 0.5-2 percent of a lubricating agent and 1-2 percent of an adhesive, wherein the disintegrating agent is composed of one or two of cross-linked carboxymethyl konjac starch sodium and polyvinylpolypyrrolidone cross-linked; and the mass ratio of cross-linked carboxymethyl konjac starch sodium to polyvinylpolypyrrolidone cross-linked is 0.5-5:0. The orally disintegrating tablet is prepared by a direct tabletting method. The preparation method is simple, the utilization value of ginseng can be improved by the obtained orally disintegrating tablet, and the orally disintegrating tablet is conveniently taken or eaten, so that the requirements of specific population are met. Meanwhile, the orally disintegrating tablet can be used for development of medicines, foods and health foods.

Description

technical field [0001] The invention belongs to the technical field of ginseng deep processing, in particular to an orally disintegrating tablet of active fresh ginseng extract and a preparation method thereof. Background technique [0002] At present, the deep-processing products of ginseng and American ginseng mostly use dried ginseng and American ginseng as raw materials, and are made into food, medicine or health care products through high-temperature extraction, concentration and drying. During the above-mentioned processing, some volatile components and heat-sensitive components in fresh ginseng and American ginseng will be lost or destroyed, which greatly reduces the activity of their deep-processed products. [0003] Malonyl ginsenoside (malonyl-ginsenoside), the active ingredient in fresh ginseng, is also called malonyl ginsenoside, which is a kind of acidic saponin with high polarity, strong hydrophilicity and easy solubility in water. The acyl bond in the compoun...

Claims

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Application Information

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IPC IPC(8): A61K36/258A61K47/36A61K9/20A23L1/29A23L33/00
Inventor 徐从立张家秋
Owner 通化鑫业生物科技研发有限公司
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