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A pharmaceutical composition for treating neurasthenia and its preparation method

A technology for neurasthenia and composition, which is applied in the direction of drug combination, medical formula, nervous system diseases, etc., can solve the problems of unguaranteed drug efficacy, not very obvious effect, inconvenient preparation and use, etc., and achieves ideal comprehensive application effect and excellent preparation process Simple and feasible, the effect of reducing resource consumption

Active Publication Date: 2018-06-08
安徽九洲方圆制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Chinese patent 200510088070.8 discloses a traditional Chinese medicine composition for invigorating the spleen and kidney, calming the mind and calming the nerves and its preparation method, wherein the liquid extract of Schisandra chinensis is soaked in 60% ethanol, which has the defects of long soaking time, large amount of ethanol and low recovery efficiency
[0008] Chinese patent 200810157309.6 discloses a method for preparing hard capsules using Acanthopanax and Schisandra. Although the capsule preparation method is improved to make it easy to carry, the concentration of active ingredients in the preparation is low and the efficacy cannot be guaranteed
[0009] In clinical application, although the traditional Chinese medicine mixture is convenient to take, there are also problems such as more medicinal taste, inconvenient preparation and use, long taking time, and not very obvious effects, etc.

Method used

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  • A pharmaceutical composition for treating neurasthenia and its preparation method
  • A pharmaceutical composition for treating neurasthenia and its preparation method
  • A pharmaceutical composition for treating neurasthenia and its preparation method

Examples

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Effect test

Embodiment 1

[0042] The preparation method of pharmaceutical composition in the present embodiment comprises the following steps:

[0043] (1) Extraction: Soak the Acanthopanax senticosus medicinal material for 30 minutes with 8 times the volume of water, extract 3 times, each time for 1 hour, filter, combine the extracts, concentrate, and obtain the Acanthopanax senticosus water decoction 1.12 (measured at 80°C) ,spare;

[0044](2) Macroporous resin adsorption: take the Acanthopanax senticosus water decoction obtained in step (1), dilute it to a total flavonoid content of 10 mg / ml with purified water, after stirring evenly, the medicinal liquid is filtered through a microporous membrane to clarify, and the filtrate Apply macroporous resin column D101 at a flow rate of 1.2BV / h, then elute with 0.4 times column volume of purified water at the same flow rate, and discard; then elute with 4 times the volume of 50% ethanol, collect the eluate, and adjust The pH is 5.2, and the 50% eluate is c...

Embodiment 2

[0049] Embodiment 2 prepares pharmaceutical composition

[0050] The preparation method of pharmaceutical composition in the present embodiment comprises the following steps:

[0051] (1) Extraction: Soak the Acanthopanax senticosus medicinal material in 12 times the volume of water for 30 minutes, extract twice, 2 hours each time, filter, combine the extracts, concentrate, and obtain Acanthopanax senticosus water decoction 1.10 (measured at 80°C) ,spare;

[0052] (2) Macroporous resin adsorption: take the Acanthopanax senticosus decoction obtained in step (1), dilute it to a total flavonoid content of 12 mg / ml with purified water, stir evenly, and filter the liquid through a microporous membrane to clarify, and the filtrate Apply macroporous resin column HPD100 with a flow rate of 1.5BV / h, then use 0.5 times of column volume purified water to elute with the same flow rate, and discard; then use 6 volume times of 50% ethanol to elute, collect the eluate, adjust The pH is 5.5...

Embodiment 3

[0057] Embodiment 3 prepares pharmaceutical composition

[0058] The preparation method of pharmaceutical composition in the present embodiment comprises the following steps:

[0059] (1) Extraction: Soak the Acanthopanax senticosus medicinal material in 10 times the volume of water for 30 minutes, extract 3 times, each time for 1 hour, filter, combine the extracts, concentrate, and obtain Acanthopanax senticosus water decoction 1.11 (measured at 80°C) ,spare;

[0060] (2) Macroporous resin adsorption: take the Acanthopanax senticosus decoction obtained in step (1), dilute it to a total flavonoid content of 15 mg / ml with purified water, stir evenly, and filter the liquid through a microporous membrane to clarify, and the filtrate Apply macroporous resin column DM130 at a flow rate of 1.2BV / h, then elute with 0.3 times column volume of purified water at the same flow rate, and discard; then elute with 4 volume times of 50% ethanol, collect the eluate, and adjust The pH is 5.6...

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Abstract

The invention relates to a pharmaceutical composition for treating neurasthenia and a preparation method thereof. The pharmaceutical composition comprises the following active ingredients: 0.03-0.5mg / ml eleutheroside E, 0.05-0.5mg / ml syringin, 0.005-0.05mg / ml isofraxidin and 0.03-0.5mg / ml schizandrin; preferably, 0.05-0.2mg / ml eleutheroside E, 0.1-0.3mg / ml syringin, 0.01-0.03mg / ml isofraxidin and 0.05-0.2mg / ml schizandrin. The pharmaceutical composition provided by the invention has the advantages that the preparation process is simple and feasible, the properties of the traditional Chinese medicine components are fully considered in the preparation process, excessive impurities are removed by macroporous adsorption resin to improve the concentration of active ingredients in the preparation and play the effects of the traditional Chinese medicine components; meanwhile, the used resin can be repeatedly used, so that resource consumption can be reduced. The traditional Chinese medicine composition prepared in the invention has a remarkable curative effect.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine preparations, and in particular relates to a pharmaceutical composition for treating neurasthenia and a preparation method thereof. Background technique [0002] Neurasthenia is a kind of neurosis mainly caused by the weakening of brain and body functions. It is a functional disease of temporary disorder of brain function and activity. A group of neurological functional disorders characterized by mental excitability, mental fatigue, emotional instability and other symptoms. Accompanied by tension, conflict, frustration, and suspicion, neurasthenia is often characterized by excitability and fatigue, and most patients have severe sleep disturbances and memory loss symptoms. [0003] In the treatment of neurasthenia in Western medicine, there are defects in the safety and dependence of drugs, which are easy to become addicted and have serious side effects. The curative effect is definite...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7034A61P25/20A61P25/28A61P25/00A61P1/14A61K31/37A61K31/09
CPCA61K31/09A61K31/37A61K31/7034A61K31/7048A61K2300/00
Inventor 方同华韩玉玲乔云峰刘玉成许照芹席桂才周广红范玉奇
Owner 安徽九洲方圆制药有限公司
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