A method for preparing troxerutin by self-priming stirring autoclave

Abstract

The invention discloses a method for preparing troxerutin by adopting a self-suction type stirred autoclave. The method comprises the following steps: adding raw materials namely rutin, ethylene oxide, a solvent namely methanol and a catalyst namely natural weakly-alkaline high-molecular compound chitosan into a self-suction type stirred autoclave, starting a digital control instrument, setting a temperature to be 70-90 DEG C, regulating a voltage to be 100V, setting a rotating speed to be 1000r / min, stirring and heating to reach a set temperature, and reacting for 3-6 hours; and stopping stirring after reaction is ended, rapidly cooling by using cold water, shutting down the digital control instrument, opening a reaction kettle, pouring out reaction liquid, adjusting a pH value of the poured reaction liquid to be 5-6 by using hydrochloric acid, performing suction filtration, adding a crystal seed into the reaction liquid subjected to suction filtration, standing for later crystallization, and filtering to obtain a product namely troxerutin. According to the method disclosed by the invention, the reaction raw materials are integrally added into the self-suction type stirred autoclave, so that material feeding steps can be simplified; and the adopted catalyst is natural weakly-alkaline high-molecular compound chitosan, so that the raw material is wide in source, and is natural, non-toxic and weakly-alkaline, and side reactions such as hydrolysis, oxidation and the like caused by strong alkaline catalysis can be avoided.

Description

technical field [0001] The invention belongs to the field of synthesis of troxerutin, and in particular relates to a method for preparing troxerutin by adopting a self-priming stirring autoclave. Background technique [0002] Troxerutin, chemical name 3',4',7-tris[O-2-hydroxyethyl]rutin, is a water-soluble product obtained by hydroxyethylation of rutin, a class of anticoagulant and Thrombolytics. Troxerutin has the effect of promoting blood circulation and removing blood stasis, can inhibit the aggregation of platelets, and has the effect of preventing thrombosis. At the same time, it can resist vascular damage caused by 5-hydroxytryptamine and bradykinin, increase capillary resistance, and reduce capillary permeability. It can prevent edema caused by increased vascular permeability, and has a significant protective effect on acute ischemic brain injury. Troxerutin can also be used to treat various diseases such as varicose veins, cerebral infarction and stroke sequelae. I...

AI Technical Summary

Problems solved by technology

In 2013, Liu Yufa et al reported the method of adding ethylene oxide and sodium hydroxide to the aqueous solution of rutin and stirring at 75°C (Chinese Chemical Letters, 2013, 24: 223-226), but strong base was used as catalyst , the later stage of the reaction is easy to cause side reactions such as hydrolysis and oxidation, which increases the difficulty of purifying trihydroxyethyl rutin

Therefore, the product prepared by the original production process needs multiple purifications to reach the new standard, which not only increases the production cost, but also reduces the yield of the product