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Drug-releasing agent based on beta-sitosterol and preparation method of drug-releasing agent

A technology of sitosterol and sustained-release agent, applied in the field of drug sustained-release agent based on β-sitosterol and its preparation, can solve the problems of low bioavailability, large fluctuation of blood drug concentration, poor dissolution rate, etc., to avoid Fluctuation of drug concentration, stabilization of drug concentration, effect of improving solubility

Inactive Publication Date: 2015-04-01
SCHOOL OF MEDICINE JIAYING UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The present invention aims at the problems existing in the prior art, and aims at the problems of poor dissolution rate, large fluctuation of blood drug concentration and low bioavailability of current β-sitosterol drugs, and prepares a drug slow-release agent of β-sitosterol. The prepared drug sustained release agent has the characteristics of stable drug concentration, high biological activity, good drug solubility and long drug effect time

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  • Drug-releasing agent based on beta-sitosterol and preparation method of drug-releasing agent
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  • Drug-releasing agent based on beta-sitosterol and preparation method of drug-releasing agent

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Embodiment Construction

[0032] Wherein in the accompanying drawings, D is a dendritic molecular structure, L is a connecting unit, and T is a terminal group.

[0033] In order to further understand the content of the present invention, the content of the invention and specific embodiments are specifically described below:

[0034] A drug sustained-release agent based on β-sitosterol and a preparation method thereof, comprising the following steps:

[0035] The first step, the preparation of clathrate, according to the mass ratio of β-sitosterol and drug carrier is 0.1:0.1~0.1:5, overprecipitation method, solution method, kneading method, grinding method, ultrasonic method, freeze-drying method or The clathrate is prepared by a spray drying method, and the drug carrier is a β-cyclodextrin-polyamide-amine type dendrimer composite material.

[0036] The β-cyclodextrin-polyamide-amine dendrimer composite material includes an unmodified β-cyclodextrin-polyamide-amine dendrimer composite material and a mo...

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Abstract

The invention relates to the technical field of beta-sitosterol medicaments and provides a drug-releasing agent based on beta-sitosterol and a preparation method of the drug-releasing agent. The drug-releasing agent based on the beta-sitosterol is applied to medicaments with the beta-sitosterol as a main drug component and is prepared from the components including a drug carrier, a hydrophilic gel material, a dissolution skeleton material and an insoluble skeleton material, wherein the drug carrier is a beta-cyclodextrin-polyamide-amine dendritic macromolecule composite, beta-sitosterol is from a plant raw material, and a host-guest inclusion complex is composed of the main drug component and the drug carrier according to the mass ratio of 0.1: 0.1-0.1: 5. A preparation method comprises the following steps: preparing the inclusion complex, mixing auxiliaries, carrying out compression moulding and the like. The drug-releasing agent based on beta-sitosterol has the characteristics of drug concentration stability, high biological activity, good drug solubility and long acting time.

Description

technical field [0001] The invention relates to the technical field of β-sitosterol medicines, in particular to a drug slow-release agent based on β-sitosterol and a preparation method thereof. Background technique [0002] β-sitosterol is a kind of phytosterol, which has the effect of significantly lowering serum cholesterol. It is of special significance to replace cholesterol as liposome membrane material for functional food. It is often used for type II hyperlipidemia and prevention of atherosclerosis, and can also relieve tension in the bladder, urethral sphincter and prostate. At room temperature, β-sitosterol is a white crystal powder, odorless and tasteless, with a melting point of 139-142°C, insoluble in water but soluble in organic solvents. [0003] Drugs containing β-sitosterol currently on the market mainly include three categories: capsules, tablets and pills, such as Qiansuotai β-sitosterol capsules; Huangbai capsules, Jiancun capsules, Relinqing capsules (co...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/40A61K31/575A61K47/32A61K47/38A61P3/06
CPCA61K47/40A61K9/2018A61K36/00A61K47/6951A61K31/575A61P3/06A61K9/2095A61K9/205
Inventor 程金生
Owner SCHOOL OF MEDICINE JIAYING UNIV
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