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Vaginal infection prevention immune globulin compound preservative

A technology of immunoglobulin and compound antibacterial agent, which is applied in the direction of antifungal agents, antibacterial drugs, antibodies, etc., can solve the problems that cannot be used for prevention, and achieve the effect of preventing vaginal dryness and no side effects

Inactive Publication Date: 2015-04-01
LANJIATANG BIOLOGICAL MEDICINE FUJIAN CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Not suitable for treatment during pregnancy, nor for prophylaxis

Method used

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  • Vaginal infection prevention immune globulin compound preservative

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Embodiment 1: Antibacterial immunoglobulin preparation example:

[0017] 1) Antigen preparation: inactivate Candida albicans culture solution and Gardnerella culture solution at 90°C for 10 minutes, respectively take 5ml of each mixture after ultrasonic crushing to obtain 10ml of combined bacterial solution, add 5ml of soybean oil and soybean lecithin Mix by 4ml and beat with ultrasonic waves for 2 minutes to prepare the combined antigen emulsion for later use.

[0018] 2) Egg antibody preparation: immunize hens with the antigen emulsion prepared in 1) (subcutaneous injection), inject 0.3ml each time, inject once every 12 days, start collecting eggs after 5 injections, and then 1 month for supplementary injection); separate the egg yolk from the collected eggs, dilute the egg yolk with 0.2% mannitol aqueous solution with 5 times the volume according to the weight of the egg yolk, stir it and then centrifuge it statically to collect the antibody-containing supernatant; ...

Embodiment 2

[0019] Embodiment 2: a kind of immunoglobulin compound antibacterial agent I formula, preparation method and using method.

[0020] Its main active ingredient and content of a kind of immunoglobulin composite bacteriostatic agent are: 1). Egg yolk immunoglobulin IgY, its content is 1000 titers in terms of antibody titer, 2). Chitosan, its content is by weight 0.1%, 3). Triclosan, its content is 0.1% by weight.

[0021] Its preparation method is as follows (taking the final product production capacity as 1 liter as example):

[0022] 1). According to the titer of the original antibody solution, take an appropriate amount and dilute it with PBS buffer until the titer of the antibody is 5000, and prepare 200ml for use;

[0023] 2). Take an appropriate amount of polyethylene glycol-20000 (PEG-20000), mix it with purified water into a 30% (w / v) aqueous solution, and prepare 100ml for later use;

[0024] 3). Take an appropriate amount of chitosan and dissolve it in 1% acetic acid ...

Embodiment 3

[0030] Example 3 An immunoglobulin compound bacteriostatic agent II formula, preparation method and application method.

[0031] Its main active ingredient and content of a kind of immunoglobulin composite bacteriostatic agent are: 1). Egg yolk immunoglobulin IgY, its content is 1000 titers in terms of antibody titer, 2). Chitosan, its content is by weight 0.2%, 3). Triclosan, its content is 0.02% by weight.

[0032] The preparation method and use method are as described in Example 2, and the concentration of the main active ingredient is adjusted appropriately according to the formula.

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Abstract

The invention relates to the field of biological medicine, in particular to a vaginal infection prevention immune globulin compound preservative. The effective active components of the compound preservative are composed of immune globulin IgY of yolk, chitosan and triclosan. The vaginal infection prevention immune globulin compound preservative is used for preparing medicine for treating the vaginitis, is capable of restraining bacteria and candida in the vagina and not damaging the ecological balance of a normal flora in the vagina, prevents vagina dryness, is free of side effects and is suitable for preventing and treating the early-stage vaginitis.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to an anti-vaginal infection immunoglobulin compound antibacterial agent. Background technique [0002] Vaginitis is a common disease in gynecological clinics, the most common of which is fungal vaginitis, which is caused by Candida infection. The most common symptoms of candida infection are excessive leucorrhea, burning and itching of vulva and vagina, exogenous dysuria, typical leucorrhea is curdled or in the form of patches, vaginal mucosa is highly red and swollen, and white thrush-like plaques can be seen attached and easily peeled off , under which is the erosion base of the damaged mucosa, or shallow ulcers may be formed, and ecchymosis may be left in severe cases. The itching symptoms of fungal vaginitis during pregnancy are particularly severe, and even restless and painful. Symptoms such as frequent urination and painful urination may also occur. The treatment of candidal vag...

Claims

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Application Information

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IPC IPC(8): A61K39/395A61P15/02A61P31/04A61P31/10A61K31/722A61K31/085
Inventor 邹潮胡博志兰增金
Owner LANJIATANG BIOLOGICAL MEDICINE FUJIAN CO LTD
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