Ruthenium (II) complex using chiral compound as ligand as well as synthesis method and application of Ruthenium (II) complex
A synthesis method and technology of complexes, which are applied in the field of medicine to achieve the effects of good medicinal value and significant in vitro anti-tumor activity
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Embodiment 1
[0047] Accurately weigh 0.5mmol of R-(+)-L and 0.5mmol of dichlorotetrakis(dimethylsulfoxide)ruthenium(II), and dissolve R-(+)-L in 55mL of 100v In / v% ethanol, dichloro tetrakis (dimethyl sulfoxide) ruthenium (II) is dissolved in the water of 15mL, two kinds of solutions are mixed, react at 80 ℃ for 24 hours, concentrate and evaporate to remove most of solvent (solvent 82% of the added amount), after cooling to room temperature, the dark green solid product was precipitated (yield 85%).
[0048] The obtained dark green solid product is identified:
[0049] (1), infrared spectrum, its spectrogram is as follows figure 1 shown.
[0050] IR(KBr):3442,3060,2918,2374,1651,1602,1568,1553,1473,1449,1416,1388,1353,1317,1281,1224,1202,1166,1147,1086,1020,9568,938,8076,20,5cm -1 .
[0051] (2), proton nuclear magnetic resonance spectrum, its spectrogram is as figure 2 shown.
[0052] 1 H NMR (500MHz, DMSO-d 6 )δ10.58(s,1H),9.27(t,J=5.7Hz,1H),8.95(d,J=7.6Hz,1H),8.69–8.61(m,2H),8...
Embodiment 2
[0064] Accurately weigh 0.5mmol of S-(–)-L and 0.5mmol of dichlorotetrakis(dimethylsulfoxide) ruthenium(II), dissolve S-(–)-L in 40mL of 80v Dissolve dichlorotetrakis(dimethylsulfoxide)ruthenium(II) in 35mL of 88v / v% ethanol in / v% methanol, mix the two solutions, react at 85°C for 24 hours, concentrate and evaporate to remove After most of the solvent (80% of the added amount of the solvent) was cooled to room temperature, the dark green solid product was precipitated (yield 80%).
[0065] The obtained dark green solid product is identified:
[0066] (1), infrared spectrum, its spectrogram is as follows Figure 5 shown.
[0067] IR(KBr):3369,3066,2962,2923,2368,1651,1602,1566,1556,1473,1440,1416,1388,1353,1320,1281,1259,1224,1202,1166,1141,1094,1048 ,1018,968,938,834,801,771,680,661,609,532,499cm-1 .
[0068] (2), proton nuclear magnetic resonance spectrum, its spectrogram is as Figure 6 shown.
[0069] 1 H NMR (500MHz, DMSO-d 6 )δ10.57(s,1H),9.24–9.22(m,1H),9.09(d,J...
Embodiment 3
[0081] Accurately weigh 0.5mmol of R-(+)-L and 1.5mmol of dichlorotetrakis(dimethylsulfoxide) ruthenium(II), and dissolve R-(+)-L in 65mL of In a mixed solution of 100v / v% methanol and 100v / v% ethanol (the volume ratio of 100v / v% methanol and 100v / v% ethanol is 71:63), dichlorotetrakis(dimethylsulfoxide) Ruthenium (II) was dissolved in 9 mL of a mixed solution consisting of water and 100v / v% methanol (water and 100v / v% methanol volume ratio 13:87), and the two solutions were mixed and reacted at 90°C for 36 hours, After concentrating and evaporating to remove most of the solvent (78% of the added amount of solvent), it was cooled to room temperature and left standing, and a dark green solid product was precipitated (yield 75%).
[0082] The obtained dark green solid product was detected by infrared spectroscopy, NMR, and electrospray mass spectrometry, and it could be determined that the obtained product was R-(+)-Ru.
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