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Method of preparing apigenin by treating adinandra nitida leaves by steam explosion technology

A technology for processing apigenin, which is applied in the field of preparing apigenin by the steam explosion method, can solve the problems of high waste water treatment cost, unfriendly environment, difficulty in adaptation, etc., achieve high production cost, expand the scope of use, and save production cost.

Inactive Publication Date: 2015-03-25
HENAN INST OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, the method for preparing apigenin from the leaves of Poplaria radiata as raw material is proposed by the applicant previously, and the method is mainly by adding a certain amount of A large amount of sulfuric acid, heating and acidolysis, collecting the precipitate and recrystallizing method to obtain apigenin (Modern Food Science and Technology, 2013, 29, 2947-2952), this method has large energy consumption, high cost, use of strong acid, waste water treatment cost High, unfriendly to the environment and other shortcomings, it is difficult to adapt to the needs of modern industrial production

Method used

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  • Method of preparing apigenin by treating adinandra nitida leaves by steam explosion technology
  • Method of preparing apigenin by treating adinandra nitida leaves by steam explosion technology
  • Method of preparing apigenin by treating adinandra nitida leaves by steam explosion technology

Examples

Experimental program
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Effect test

Embodiment 1

[0027] Take 100 g of poplar leaves and dry them at 65 °C until the dry matter content reaches 87.6%, put them into a steam explosion equipment, maintain a pressure of 0.5 MPa for 2 min, and then explode instantly to obtain poplar leaves in an explosive state, and dry them to The mass content of dry matter reaches 87.8%, and it is pulverized and sieved to 40 mesh to obtain the processed raw material. Put the above raw materials into a condensing reflux device, add 1000 mL of 70% ethanol solution, extract in a water bath at 60 °C for 3 h, and then filter with suction to obtain an apigenin extract. The extract was evaporated in vacuo at 60°C to remove ethanol, and the precipitate precipitated from the remaining solution was collected and dried to obtain crude apigenin. The obtained crude product was added to 1000 mL of ethanol, heated and dissolved in a water bath at 80 °C for 3 h, and then suction-filtered, and the filtrate was allowed to cool and recrystallized to obtain 8.53 g...

Embodiment 2

[0030] 100 g of poplar leaves were dried at 65 ℃ until the mass content of dry matter reached 87.7%, put into steam explosion equipment, maintained at a pressure of 1.0 MPa for 1.5 min, and then exploded instantly to obtain poplar leaves in an explosive state, which were dried to The dry matter mass content reaches 87.9%, and pulverizes and sieves 40 orders, obtains the raw material after processing. Put the above raw materials into a condensing reflux device, add 1500 mL of 60% ethanol solution, extract in a water bath at 80 °C for 2.5 h, and then filter with suction to obtain an apigenin extract. The extract was evaporated in vacuo at 50° C. to remove ethanol, and the precipitate precipitated in the remaining solution was collected and dried to obtain crude apigenin. The obtained crude product was added to 2000 mL of ethanol, dissolved at 80 °C for 2.5 h, then suction filtered, and the filtrate was allowed to cool and recrystallized to obtain 8.87 g of apigenin with a purity...

Embodiment 3

[0033] 100 g of poplar leaves were dried at 65 ℃ until the dry matter content reached 87.8%, put into steam explosion equipment, maintained at a pressure of 2.0 MPa for 1.0 min, and then exploded instantly to obtain poplar leaves in an explosive state, which were dried to The mass content of dry matter reaches 87.6%, and it is pulverized and sieved to 40 mesh to obtain the processed raw material. Put the above raw materials into a condensing reflux device, add 2500 mL of 50% ethanol solution, extract in a water bath at 70 °C for 2 h, and then filter with suction to obtain an apigenin extract. The extract was evaporated in vacuo at 40°C to remove ethanol, and the precipitate precipitated from the remaining solution was collected and dried to obtain crude apigenin. The obtained crude product was added to 2500 mL of ethanol, dissolved at 80 °C for 2 h, then suction filtered, and the filtrate was cooled and recrystallized to obtain 8.25 g of apigenin with a purity of 95.89%.

[0...

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Abstract

The invention discloses a method of preparing apigenin by treating adinandra nitida leaves by a steam explosion technology. The method comprises the following steps: performing steam explosion treatment on the adinandra nitida leaves, controlling the pressure in the steam explosion process to 0.5-3.0MPa and keeping the process for 0.5-2.0 minutes; then, instantly exploding to obtain the exploded adinandra nitida leaves, converting flavonoids such as camellianin A and camellianin B in the adinandra nitida leaves at a high temperature under high pressure into aglycone apigenin of the flavonoids, and obtaining the apigenin with relatively high purity by taking the treated adinandra nitida leaves as raw materials through organic solvent extraction and recrystallization. The preparation process of apigenin is high in yield, good in purity, low in energy consumption, free of acid and alkaline, less in wastewater emission, beneficial to environmental protection and suitable for industrial production.

Description

[0001] Technical field [0002] The present invention involves a method of preparing celery in the bright leaves and Yangtong leaves, especially the production technology of steam blasting law that is conducive to environmental protection. [0003] Background technique [0004] Celenicin, also known as lutein and oceanin, is an important flavonoid.Research in recent years has shown that celery has a variety of physiological activity functions: ① anti -cancer, which has a significant inhibitory effect on the start, promotion, and development of cancer.Good treatment effects; ② anti -spasm, lowering blood pressure, diastolic blood vessels; ③ Anti -inflammatory effect by inhibiting the high expression of macrophageed enzymes; ④ By enhancing GABA can play a sedation and anxiety effect; ⑤ A variety of typesGram -negative bacteria have inhibitory effects.Because celery vegetarian has the above biological activity, it has a wide range of application prospects in the field of functional ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D311/30C07D311/40
CPCC07D311/30C07D311/40
Inventor 刘本国陈玉珍耿升陈春刚莫海珍
Owner HENAN INST OF SCI & TECH
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