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Method for preparing cardiovascular disease drug micropills

A cardiovascular and granular pellet technology, which is applied in the preparation of Shexiang Baoxin Pills and the preparation of cardiovascular disease drug pellets, can solve the problems of wide particle size distribution of pellets and easy formation of irregular pellets, etc., to achieve The effect of reducing labor difficulty and labor intensity, reducing volatilization, and reducing restrictions

Active Publication Date: 2015-03-25
HEHUANG PHARMA SHANGHAI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantage is that the particle size distribution area of ​​the obtained pellets is wide, and it is easy to form irregular pellets.

Method used

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  • Method for preparing cardiovascular disease drug micropills
  • Method for preparing cardiovascular disease drug micropills
  • Method for preparing cardiovascular disease drug micropills

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Choice of preparation method:

[0041] A systematic study was carried out on the mechanized preparation methods of Shexiang Baoxin Pills, including extrusion spheronization method, centrifugal granulation method, and fluidized bed side spray method. It was found that these three methods could not achieve mechanized preparation of Shexiang Baoxin Pills. The relevant experimental studies are as follows:

[0042] 1. Research on the process of preparing the core of Shexiang Baoxin pills by extrusion spheronization

[0043] Composition of medicinal ingredients: 5 parts of artificial musk, 5 parts of ginseng extract, 3 parts of artificial bezoar, 11 parts of cinnamon, 1 part of toad venom, 8 parts of borneol, and 7 parts of storax.

[0044] Different ratios of ethanol aqueous solutions were selected as binders, and the process research on the preparation of pellet cores by extrusion spheronization was carried out. The results are shown in Table 1 below.

[0045] Table 1: Pr...

Embodiment 2

[0065] Mechanical manufacturing process and parameter optimization of Shexiang Baoxin Pills:

[0066] The preparation method of the present invention adopts the combination of the molding method and the general method to prepare Shexiang Baoxin Pills. The following will be specifically described in conjunction with examples.

[0067] Apparatus and medicine used in the embodiment are as follows:

[0068] instrument:

[0069] FA2104N electronic balance (Shanghai Precision Scientific Instrument);

[0070] YUJ-16B desktop pill making machine (Tianshui Huayuan Pharmaceutical Equipment Technology Co., Ltd.);

[0071] Drug ingredients and their weight content:

[0072] Shexiang Baoxin Pills are composed of A powder and B powder.

[0073] A powder: 7 parts of styrax, 3 parts of artificial musk, 3 parts of ginseng extract, 2 parts of artificial bezoar, 8 parts of cinnamon, 1 part of toad, and 8 parts of borneol;

[0074] B powder: 2 parts of artificial musk, 12 parts of ginseng e...

Embodiment 3

[0133] Comparative study on the dissolution behavior of multiple components of Shexiang Baoxin Pills:

[0134] A multi-component quantitative method was used to investigate whether there was a significant difference in the dissolution behavior of Shexiang Baoxin pills prepared by the two-step process of plastic method and general method and the original process.

[0135] Instruments and reagents

[0136] FA2104N electronic balance (Shanghai Precision Scientific Instrument);

[0137] XP205 Electronic Analytical Balance (Mettler-Toledo Instrument Co., Ltd.);

[0138] 1200 liquid chromatograph (Agilent Technologies Co., Ltd.);

[0139] Shiseido CAPCELLPAKC18 column (4.6mmI.D.×250mm);

[0140] D-800 Intelligent Dissolution Apparatus (Tianjin University Radio Factory);

[0141] Shexiang Baoxin Pill I (sample provided by Hehuang, hereinafter referred to as HH), Shexiang Baoxin Pill II is a granular pill (prepared by the combined process of the plastic method and the general meth...

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Abstract

The invention provides a method for preparing cardiovascular disease drug micropills. The method comprises the following steps: adding 6-13 weight parts of storax into ethanol aqueous solution, and uniformly mixing; grinding the following components into fine powder of 80-100mesh in parts by weight: 1-5 parts of musk, 1-5 parts of ginseng extract, 1-5 parts of calculus bovis, 3-11 parts of cinnamon, 1-6 parts of venenum bufonis and 6-14 parts of borneol, uniformly mixing the fine powder with the ethanol aqueous solution of storax, and adding water to prepare a soft material; extruding the prepared soft material to prepare pills; grinding 1-5 parts of musk, 10-20 parts of ginseng extract, 1-5 parts of calculus bovis, 7-15 parts of cinnamon and 1-6 parts of venenum bufonis into fine powdr of 80-100mesh; and rolling the prepared pills, spraying 40-60 percent of ethanol aqueous solution, and adding the prepared fine powder, so that the fine powder is adhered to the pills by slurry. According to the preparation method, a plastic molding method and a pill processing method are combined, so that the production efficiency of heart-protecting musk pills can be improved, the yield is improved, the influence of human factors on the product is reduced in the production process, and the labor intensity is reduced. Therefore, the drug powder is constant in ratio, and the product quality is stable.

Description

Technical field [0001] The present invention relates to the technical field of traditional Chinese medicine, specifically to a method for preparing microparticle pills for cardiovascular diseases, and in particular to a method for preparing Shexiang Baoxin Pills. Background technology [0002] Shexiang Baoxin Pill is a compound preparation made of 7 traditional Chinese medicines including musk, ginseng extract, bezoar, cinnamon, styrax, toad venom, and borneol. Its chemical composition is complex and the physical and chemical properties of the ingredients vary greatly. Among them, the main drugs are musk and toad venom, which have the functions of pungent, dispersing stagnation and clearing the orifices with aroma; ginseng extract can replenish qi and treat the symptoms while taking care of the root cause. It can nourish qi and smooth the circulation of qi and blood; cinnamon warms the blood vessels, helps yang and relieves pain; borneol is pungent and cool. It clears the or...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/54A61K9/16A61J3/06A61K35/65A61K35/55A61K35/413A61K31/045
CPCA61J3/06A61K9/16A61K31/045A61K35/413A61K35/55A61K35/65A61K36/185A61K36/258A61K36/54A61K2236/333A61K2236/39A61K2236/51A61K2300/00
Inventor 周俊杰冯怡詹常森鲜洁晨陈忠樑阮克锋李淞明王玲周国平向阳
Owner HEHUANG PHARMA SHANGHAI
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