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Pharmaceutical composition for treating diabetic nephropathy and application of pharmaceutical composition

A technology of diabetic nephropathy and composition, applied in the field of pharmaceutical composition for treating diabetic nephropathy, to achieve the effect of lowering blood sugar, controlling urine output, and important clinical application significance

Inactive Publication Date: 2015-03-25
QINGDAO MUNICIPAL HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no literature report on the preparation of hypoglycemic or urinary protein drugs using clover umbrella as raw material.

Method used

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  • Pharmaceutical composition for treating diabetic nephropathy and application of pharmaceutical composition
  • Pharmaceutical composition for treating diabetic nephropathy and application of pharmaceutical composition
  • Pharmaceutical composition for treating diabetic nephropathy and application of pharmaceutical composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Embodiment 1: the preparation of clover umbrella extract

[0017] Remove impurities from the dry bark of Cypress ginseng, crush it through a 32-mesh sieve through a portable high-speed traditional Chinese medicine grinder, weigh 350g of Sanye Luoshen powder, put it in an extraction device, and add 4L of ethanol with a volume concentration of 95%. Solution, heated and refluxed in a water bath at 85°C for 1.5h, extracted twice in total, combined medicinal juice, suction filtered, discarded medicinal residues, and the filtrate was concentrated into a paste using a rotary evaporator to recover ethanol under reduced pressure, freeze-dried to obtain Trilobella Extract dry powder.

Embodiment 2

[0018] Embodiment 2: the preparation of clover umbrella extract

[0019] Remove impurities from the dried stem bark of Panax ginseng, crush it through a 32-mesh sieve through a portable high-speed traditional Chinese medicine grinder, weigh 286g of Sanye Luoshen powder, put it in an extraction device, and add 3L of ethanol with a volume concentration of 95%. Solution, heated and refluxed in a water bath at 85°C for 1.5h, extracted twice in total, combined medicinal juice, suction filtered, discarded medicinal residues, and the filtrate was concentrated into a paste by using a rotary evaporator to recover ethanol under reduced pressure, freeze-dried, and obtained Shamrock Extract dry powder.

Embodiment 3 3

[0020] Example 3 Experimental Study on the Effect of Trilobella clover extract on Diabetic Nephropathy Model Rats

[0021] Select 60 healthy male adult SD rats with a body mass of (350±40) g. 60 rats were randomly divided into sham operation group, model control group, high-dose and low-dose groups of clover umbrella extract, 15 rats in each group, fed with high-fat diet, and unlimited water intake.

[0022] The sham operation group underwent sham operation, and the other three groups underwent intraperitoneal injection of streptozotocin after unilateral renal ligation. Before the operation, the rats were fasted for 12 hours and injected with pentobarbital sodium solution for anesthesia. After anesthesia was confirmed, the rats in the sham operation group were incised and sutured after incision of the skin and muscle layers, and the renal arteries, veins and ureters were ligated along the renal pedicles in the other groups. At 2 weeks after the operation, after fasting for 18...

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Abstract

The invention discloses a pharmaceutical composition for treating diabetic nephropathy and application of the pharmaceutical composition. The composition is prepared from a traditional Chinese medicine extract and auxiliary materials, wherein the traditional Chinese medicine extract is an alcohol extract which is extracted from brassaiopsis tripteris as a raw material by using an ethanol solution of which the volume concentration is 92%-98%. According to the pharmaceutical composition disclosed by the invention, blood glucose and glycosylated hemoglobin of a patient with diabetic nephropathy can be lowered; the urine volume is controlled; the urinary albumin excretion is reduced; and the pharmaceutical composition plays repairing and improving roles in functions of glomerulus and kidney tubules, so that the kidney function of the patient is improved.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine and relates to a medicine for treating diabetic nephropathy, in particular to a pharmaceutical composition for treating diabetic nephropathy and its application. Background technique [0002] Diabetic nephropathy (Diabetic Nephropathy, DN) is one of the common complications of diabetes. As the most common microvascular complication of diabetes, it has become the most common cause of end-stage renal disease. The pathogenesis of diabetic nephropathy is complex. A large number of clinical and experimental studies have shown that metabolic disorders and chronic hyperglycemia are the main cause of diabetic nephropathy. Proteinuria is also an important risk factor for the progressive development of nephropathy. It can be intermittent proteinuria at the beginning, and later Gradually aggravating into persistent proteinuria, due to long-term proteinuria and protein metabolism disorder...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/25A61P3/10A61P13/12
CPCA61K36/25A61K2236/333A61K2236/39
Inventor 傅海霞李绍莉姜玲范新萍王潇玲
Owner QINGDAO MUNICIPAL HOSPITAL
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