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Tartaric acid valnemulin cyclodextrin inclusion compound and preparation method thereof

A technology of cyclodextrin inclusion compound and vornimulin, which is applied in the direction of pharmaceutical formulations, medical preparations of non-active ingredients, active ingredients of esters, etc., can solve the problems of restricting the use of drugs and single use of premixes , to achieve the effect of improving water solubility and stability

Inactive Publication Date: 2015-03-18
RINGPU TIANJIN BIOLOGICAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, warnemulin tartrate is mainly used as a reference substance or standard substance for drug testing. Some researchers have also developed a premix of warnemulin tartrate. drug use

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Preparation of cyclodextrin inclusion complex of warnimulin tartrate by saturated aqueous solution method:

[0019] The molar ratio of warnemulin tartrate to β-cyclodextrin is 1:1

[0020] The specific preparation method is as follows: dissolve the formula amount of warnemulin tartrate with methanol, the weight-to-volume ratio of warnemulin tartrate to methanol is 1:2, weigh β-cyclodextrin according to the molar ratio to prepare a 50°C aqueous solution, and mix the two Mix the two solutions, stir for 60 minutes, stir, cool and cool down so that the formed clathrate precipitates, filter the precipitated clathrate, wash away the monomeric warnemulin tartrate with methanol, and dry to obtain the warnemulin tartrate cyclopaste Fine clathrate.

Embodiment 2

[0022] Preparation of cyclodextrin inclusion complex of warnimulin tartrate by ultrasonic method:

[0023] The molar ratio of warnemulin tartrate to hydroxypropyl-β-cyclodextrin is 1:3

[0024] Concrete preparation method is as follows: warnemulin tartrate and hydroxypropyl-beta-cyclodextrin are weighed in molar ratio, put in conical flask, add methanol to dissolve, warnemulin tartrate and methanol weight volume ratio are 1: 2. Put it in an ultrasonic wave for 15 minutes, and evaporate to dryness under reduced pressure to obtain the inclusion compound of vornimulin tartrate.

Embodiment 3

[0026] Preparation of cyclodextrin inclusion complex of warnimulin tartrate by grinding method:

[0027] The molar ratio of warnemulin tartrate to hydroxypropyl-β-cyclodextrin is 1:8

[0028] The specific preparation method is as follows: dissolve the formula amount of warnemulin tartrate with methanol, the weight-to-volume ratio of warnemulin tartrate to methanol is 1:2, and weigh the cyclodextrin according to the molar ratio of warnemulin tartrate to cyclodextrin 1:8. Dextrin, then add water with the same volume as methanol and mix, fully grind into a paste, dry at low temperature, then wash with methanol to remove the monomer warnemulin tartrate, and dry to obtain the warnemulin tartrate cyclodextrin inclusion complex things.

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PUM

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Abstract

The invention relates to a tartaric acid valnemulin cyclodextrin inclusion compound and a preparation method thereof, and belongs to the technical field of veterinary medicines. The tartaric acid valnemulin cyclodextrin inclusion compound provided by the invention can be used for preparing a tartaric acid valnemulin injection, soluble powder, a solvent and the like, and is used for preventing and treating animal diseases such as swine dysentery, enzootic pneumoniae, pig colon spirochetosis and proliferative enteropathies.

Description

technical field [0001] The invention belongs to the technical field of veterinary medicine, and in particular relates to a warnimulin tartrate cyclodextrin inclusion compound and a preparation method thereof. Background technique [0002] Warnemulin hydrochloride was first synthesized by Sandoz Company in 1984 using pleuromutilin as a raw material. It belongs to the same class of drugs as tiamulin and is a special antibiotic for animals. Warnemulin hydrochloride is mainly used as a feed premix to prevent swine dysentery, endemic pneumonia, porcine spirochete, porcine proliferative enteropathy, etc. Premix is ​​the main dosage form for oral administration to livestock and poultry. Compared with injection, it is more convenient for administration and saves breeding costs. Although warnemulin hydrochloride has a good anti-mycoplasma effect, the raw material drug has disadvantages such as hygroscopicity, strong powder irritation, instability to light, and easy decomposition whe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/48A61K31/22A61P31/04
Inventor 王小武孙微微刘拓
Owner RINGPU TIANJIN BIOLOGICAL PHARMA
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