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Method for extracting flavone from folium ginkgo

A technology of ginkgo flavonoids and ginkgo leaves is applied in the production of bulk chemicals, organic chemistry, etc., and can solve the problems of cumbersome process, low active ingredients, low extraction rate, etc., and achieve the effect of simple process

Inactive Publication Date: 2015-03-04
GUANGXI LAIJI BIOENG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The content of flavonoids and lactones in active substances determines the medicinal value of Ginkgo biloba. To obtain more flavonoids, the key lies in the extraction method of Ginkgo biloba. In the traditional extraction process, the solvent easily enters the cells under heating conditions. However, soluble substances have higher solubility under hot conditions, and are dissolved successively to show high permeability, resulting in low extraction rate, low active ingredients, cumbersome process, and long production cycle.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Grind 1000g of ginkgo leaves, and pass the powder through a 10-mesh sieve; immerse the crushed ginkgo leaf powder in 10L of warm water at 40°C for leaching, the extraction time is 3 hours, extract once per hour, and extract three times in total. Filter and combine the filtrates, concentrate and dry the extract to obtain 100g of solid powder, dissolve it in 500ml of warm water at 40°C, then extract it 3 times with anhydrous ethyl acetate solvent, and continue to use anhydrous ethyl acetate for multiple extractions. The first crystallization treatment, the solid-liquid ratio during the crystallization process is 1:5 (V / W), the above-mentioned crude crystallization product is subjected to a supercritical CO2 extraction and drying treatment, the pressure of the extraction kettle is 10MPa, the extraction temperature is 40°C, and the extraction time is In 30 minutes, you can get ginkgo flavonoids with a purity of 98.7%.

Embodiment 2

[0016] Grind 1000g of ginkgo leaves, and pass the powder through a 30-mesh sieve; immerse the crushed ginkgo leaf powder in 10L of warm water at 60°C for leaching, the extraction time is 3 hours, extract once per hour, and extract three times in total. Filter and combine the filtrates, concentrate and dry the extract to obtain 100g of solid powder, dissolve it in 500ml of warm water at 50°C, then extract it 3 times with anhydrous ethyl acetate solvent, and continue to use anhydrous ethyl acetate for multiple extractions. The first crystallization treatment, the solid-liquid ratio during the crystallization process is 1:5 (V / W), the above-mentioned crude crystallization product is subjected to a supercritical CO2 extraction and drying treatment, the pressure of the extraction kettle is 20MPa, the extraction temperature is 50°C, and the extraction time is In 45 minutes, the ginkgo flavonoids with a purity of 99.2% can be obtained.

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Abstract

The invention discloses a method for extracting flavone from folium ginkgo and relates to the technical field of an extraction technology. The method provided by the invention comprises the following steps: dry folium ginkgo is crushed, a folium ginkgo powder is immersed in warm water of 40-60 DEG C for extraction, solid-to-liquid ratio during extraction is 1:10 (V / W), extraction time is 3 hours, extraction is carried out for three times, filtration is carried out after extraction, and filtrates are merged; and dissolution is carried out by the use of 5 times volume of water of 40-50 DEG C after an extract liquid is concentrated and dried, extraction is carried out for three times by the use of an anhydrous ethyl acetate solvent, multiple crystallization treatments are carried out continuously by the use of anhydrous ethyl acetate, solid-to-liquid ratio during the crystallization process is 1:5, and a crude crystallized product undergoes one time of supercritical CO2 extraction and drying process so as to obtain ginkgo flavone with purity of over 98%. The technology of the invention is simple. Extraction separation and crystallization purification are directly carried out without complex, time-consuming and energy-consumption technologies such as column chromatography and the like. By supercritical CO2 extraction, purity of ginkgo flavone exceeds 98%.

Description

technical field [0001] The invention relates to the technical field of extraction technology, in particular to a method for extracting flavonoids from ginkgo leaves. Background technique [0002] Ginkgo biloba plant is a unique tree species in my country, also known as ginkgo tree, which can be more than a thousand years old. It is an ancient Permian relict plant. It is known as a "living fossil" in the plant kingdom and is the oldest relict plant in the existing seed plants. . [0003] Modern science shows that the chemical composition of Ginkgo biloba is very complex, among which Ginkgo biloba contains flavonoids, terpenoids, phenols, beneficial trace elements and various amino acids and other active ingredients. Ginkgo biloba extract contains a large amount of ginkgo flavonoids and ginkgolides, which can increase cerebrovascular flow, improve cerebrovascular circulation, protect brain cells, exaggerate coronary arteries, prevent angina pectoris and myocardial infarction, ...

Claims

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Application Information

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IPC IPC(8): C07D311/30C07D311/40
CPCC07D311/30C07D311/40Y02P20/54
Inventor 刘忠群
Owner GUANGXI LAIJI BIOENG
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