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Artificial lens with polyhedral oligomeric silsesquioxane-modified surface and preparation method thereof

A technology of polysilsesquioxane and intraocular lens, applied in the direction of intraocular lens, eye implant, etc., which can solve the problems of affecting vision recovery and increasing the financial burden of patients, so as to avoid toxic and side effects, simple manufacturing process and convenient Disinfection effect

Active Publication Date: 2015-03-04
WENZHOU MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After cataract not only seriously affects postoperative vision recovery, but also requires secondary surgery, which increases the financial burden of patients

Method used

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  • Artificial lens with polyhedral oligomeric silsesquioxane-modified surface and preparation method thereof
  • Artificial lens with polyhedral oligomeric silsesquioxane-modified surface and preparation method thereof
  • Artificial lens with polyhedral oligomeric silsesquioxane-modified surface and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0026] Firstly, take a clean intraocular lens, and make the surface with amine groups through the surface treatment of silane coupling agent containing amino functional groups: choose a soft intraocular lens, its material can be polyhydroxyethyl methacrylate, immerse to 1×10 -5 mol / L aqueous solution of γ-aminopropyltriethoxysilane, hydrolyzed for 3 hours, the surface of the intraocular lens material is covered with amine groups, washed with water, and dried with nitrogen gas for later use. Then the surface-aminated intraocular lens was immersed into a mixed solution containing carbodiimide (DCC), N-hydroxysuccinimide (NHS) and carboxyl group-containing POSS. This example takes the carboxylated POSS (Meleamic acid Cyclohexyl POSS) molecule as an example, the molecular structure is as follows: , where DCC: 2mg / mL; NHS: 4mg / mL, stirring continuously at room temperature for 3 hours, the carboxylated POSS (Meleamic acid Cyclohexyl POSS) was bonded by DCC / NHS coupling through th...

Embodiment 2

[0028] First, take a clean intraocular lens, and treat the intraocular lens with alkali to bring carboxyl groups on the surface: choose a rigid intraocular lens, the material of which is polymethyl methacrylate, immerse in 1 mol / L NaOH solution, hydrolyze 2 hour, the ester and alkali hydrolyzed on the surface of the intraocular lens material to bring carboxyl groups, washed with water, and dried with nitrogen gas for later use. The surface carboxylated intraocular lens was then immersed in a mixed solution containing carbodiimide (DCC), N-hydroxysuccinimide (NHS) and POSS containing amine groups. In this example, the aminated POSS (3-aminopropyl-heptaisobutyl substituted POSS) molecule is taken as an example, and the molecular structure is as follows: , where DCC: 3mg / mL; NHS: 6mg / mL, stirring continuously at room temperature for 4 hours, aminated POSS (3-aminopropyl-heptaisobutyl substituted POSS) through the amine group on its molecule and the surface of the material Th...

Embodiment 3

[0030] First, take a clean intraocular lens, and make the surface with a thin layer of polydopamine through dopamine self-polymerization surface treatment: choose a soft intraocular lens, and its material is polydimethylsiloxane PDMS silicone rubber. Immerse in the dopamine HEPEs buffer solution, adjust the pH to 8.5, stir at room temperature, bring a thin layer of polydopamine on the surface of the intraocular lens material, and wash it with the HEPEs buffer solution; then, put the intraocular lens material with a thin layer of polydopamine on the surface Immerse into the POSS solution with mercapto or amine groups. In this example, the mercapto POSS (3-mercaptopropyl-heptaisobutyl substituted POSS) molecule is taken as an example, and the molecular structure is as follows:

[0031] , in which the dopamine solution is 2 mg / mL; stirring at room temperature for 0.5 hours, mercapto POSS (3-mercaptopropyl-heptaisobutyl substituted POSS) is grafted to the surface of the material ...

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Abstract

The invention relates to an artificial lens with a polyhedral oligomeric silsesquioxane-modified surface and a preparation method thereof. The preparation method of the artificial lens with the polyhedral oligomeric silsesquioxane-modified surface includes the following process steps: a clean artificial lens is chosen, and by surface pretreatment, a chemically active surface is obtained; the chemically active surface chemically reacts with POSS (polyhedral oligomeric silsesquioxane) containing reactable functional groups, so that the artificial lens, on the surface of which is the POSS is grafted, is obtained. The invention has the advantage that a surface composite micronanostructure is obtained by nano POS modification, so that the super-hydrophobic surface is obtained to inhibit the adhesion of epithelial cells on the lens, and thereby the highly biocompatible artificial lens is obtained.

Description

technical field [0001] The invention relates to the field of medical implant materials and device surface modification, in particular to a cage-shaped polysilsesquioxane-modified intraocular lens and a preparation method thereof. Background technique [0002] Cataract is a major cause of blindness worldwide. The current clinical treatment mainly uses phacoemulsification combined with intraocular lens implantation. However, intraocular lenses such as polymethyl methacrylate, polyhydroxyethyl methacrylate hydrogel and silicone rubber widely used at present generally have foreign body reactions after implantation in human eyes. After intraocular lens implantation, the lens capsule becomes opacified again, also known as after-onset cataract, which is the main complication that seriously affects the visual recovery of patients after intraocular lens implantation. Post-cataract not only seriously affects postoperative vision recovery, but also requires secondary surgery, which i...

Claims

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Application Information

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IPC IPC(8): A61F2/16
Inventor 林全愧韩月梅陈浩
Owner WENZHOU MEDICAL UNIV
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