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Biodegradable antibacterial composite fibers and preparation method thereof

A composite fiber and mixed solvent technology, applied in the field of materials science, can solve the problems of high infection probability, poor patient treatment experience, and large uncertainty, and achieve good biological safety, prevent skin ulcer infection, and enhance affinity Effect

Inactive Publication Date: 2015-02-04
SHANGHAI INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Aiming at the above-mentioned technical problems in the prior art, the present invention provides a degradable antibacterial composite fiber and its preparation method. The degradable antibacterial composite fiber and its preparation method should solve the problem of biological materials in the prior art. In skin treatment, there are technical problems such as large uncertainty, high infection rate, and poor treatment experience for patients

Method used

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  • Biodegradable antibacterial composite fibers and preparation method thereof
  • Biodegradable antibacterial composite fibers and preparation method thereof
  • Biodegradable antibacterial composite fibers and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Such as figure 1 Shown, a kind of preparation method of degradable antibacterial composite fiber comprises the steps:

[0037] 1) Prepare PLA solution;

[0038] Use an electronic balance to measure 12 mg of PLA solid particles and pour them into brown jars, add 10 ml of mixed solvent, and place them on a magnetic stirrer at 25°C until the solids are completely dissolved. The molecular weight of polylactic acid is 200,000Da, and the mixed solvent is dichloromethane:N,N-dimethylformamide mixed at a ratio of 1:1.

[0039] 2) Fully mix the nanoparticles and the polylactic acid solution to form a mixed solution, and perform ultrasonic dispersion treatment on the mixed solution under the action of a surfactant;

[0040] The parameters are as follows: the content of nanoparticles is respectively: 2%, 4%, 6%, 8% and 10% of the mass of polylactic acid. Surfactant: Tween Tween60 (adapted to nano-ZnO system) - 12% of the mass of ZnO; Tween Tween80 (adapted to nano-TiO 2 system...

Embodiment 2

[0046] Example 2 Test the suspension stability of nano ZnO

[0047] The suspension stability study results of ZnO / PLA solutions with Tween 60 and Tween 80 as surfactants are shown in Table 3, and Table 3 can be used to show that the content and type of surfactants affect the ZnO sedimentation situation, where, ( ×) means no sedimentation or stratification within the observation time;

[0048] (√) indicates that subsidence or stratification has occurred within the observation time;.

[0049] Table 1

[0050]

[0051] In the above table, 3 groups of well-mixed and non-stratified formulations can be selected for subsequent TEM tests. The test results are shown in Table 2, and Table 2 shows the TEM observation formulations.

[0052] type Determination of content Ultrasound time Tween60 12% 15min Tween60 12% 30min Tween80 8% 60min

Embodiment 3

[0053] Example 3 to nano TiO 2 Suspension Stability Tested

[0054] Taking Table 3 as an example, the embodiment of the present invention uses 12% PLA solution as the dispersion matrix, selects the compound system of dichloromethane and N,N-dimethylformamide (1:1) as the solvent, and mixes a certain amount of Nano-TiO 2 After being placed in the solution for a certain period of ultrasonic dispersion, the settling time of the nanoparticles in the PLA solution was observed. In this experiment, nano-TiO 2 Stable suspension in PLA solution for 4 hours as a reference basis and evaluation standard. The experimental results are shown in Table 3, and Table 3 is used to represent the effect of different surfactant types and contents on the nano-TiO 2 Influence of suspension stability, nano-TiO in the table 2 The suspension stability observation time is 240min.

[0055] table 3

[0056]

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Abstract

The present invention relates to biodegradable antibacterial composite fibers, which comprise polylactic acid, nanoparticles and a surfactant, wherein the nanoparticles are nanometer zinc oxide or nanometer titanium oxide, and a weight ratio of the polylactic acid to the nanoparticles to the surfactant is 100:2-10:0.08-1.2. The present invention further provides a preparation method of the biodegradable antibacterial composite fibers, wherein the preparation method comprises a polylactic acid solution preparation step. The preparation method specifically comprises: dissolving polylactic acid in a mixed solvent, wherein the polylactic acid concentration is 10-15 g / L; adding nanoparticles and a surfactant to the polylactic acid solution, and completely mixing to form a mixed solution; carrying out an ultrasonic dispersion treatment on the mixed solution; and placing the stable suspension solution after being subjected to the ultrasonic dispersion treatment in a preset syringe, and carrying out a spinning treatment on the suspension solution according to the preset injection speed. According to the present invention, the preparation method is simple and feasible, and the prepared composite fibers have a certain strength, good biological safety, and good antibacterial property.

Description

Technical field [0001] The present invention is a material science, and especially involves a biochemical material. Specifically, it is a degradable antibacterial composite fiber and its preparation method. Background technique [0002] With the fast -paced life of modern society and the trend of social aging, people have put forward increasing requirements for the field of medical technology.Accelerating wound healing is one of the focus of skin therapy.Studies have shown that the degree of moisturizing and antibacteriality of the wound environment is the main factor affecting wound healing.Ordinary medical dressings are made of cotton fiber and do not have bacteriostatic and bactericidal effects. They can only shield a small amount of bacteria. Therefore, the surface of the dressing can easily breed bacteria.A special medical dressing with high moisturizing and high antibacterial functions plays an important role in the treatment process, becoming a research hotspot in the fiel...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D01F6/92D01F1/10D01D1/02A61L27/60A61L27/54A61L27/18
Inventor 单晓茜
Owner SHANGHAI INST OF TECH
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