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Microcapsule production technology

A production process and microcapsule technology, which is applied in the direction of microcapsule preparation, capsule delivery, microsphere preparation, etc., can solve the problems of complex preparation process, safety of auxiliary materials, melting of wall materials, etc., and achieve simple operation of the preparation process, safe and reliable use , the effect of preventing the release of the core material

Inactive Publication Date: 2015-02-04
ZHEJIANG CHUNBAO CAPSULES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The microcapsule production process generally has the defects of complex preparation process, unreasonable selection of wall materials, inability to prevent volatilization of unstable raw materials, and fast release of core materials
In addition, existing problems also include the high cost of wall materials and the safety of auxiliary materials. It is necessary to actively look for wall materials that are easy to get, cheap, widely applicable, and safe for humans and the ecological environment; the effect of stirring speed on the particle size of microcapsules The stirring speed in the emulsification stage should not be too fast, and the high speed will also cause a large amount of foam in the system, which will reduce the strength of the capsule; if the stirring speed is too slow, the core material will not be emulsified, and the embedding rate and release performance of the product will be greatly affected. Influence; the drying temperature of microcapsules has a great influence on the performance of microcapsules. The reason is that during drying, if the temperature is too low, the product strength will decrease, and storage will easily cause adhesion and agglomeration. If the temperature is too high, the wall material will melt and the core material will be easily released.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0041] (a) Preparation of the wall material solution: select the wall material, weigh a quantitative amount of the wall material, soak and swell the wall material, heat and stir to make it dissolve, keep warm, set aside, and control the wall material concentration in the wall material solution to be 30 %~40%;

[0042] (b) Emulsion mixing of core material and wall material: select the core material, weigh a quantitative core material, add emulsifier dropwise to the core material, oscillate to dissolve, add the core material emulsion to the wall material solution, and place it on a constant temperature water bath Stir to form a mixed emulsion of core and wall materials;

[0043] (c) ultrasonic embedding; placing the mixed emulsion of the core material and the wall material under ultrasonic conditions to embed for 30 minutes, and leave it to stand for subsequent use;

[0044] (d) Homogeneous dispersion: After the mixed emulsion of the core material and the wall material is homog...

Embodiment 1

[0048] Embodiment 1: ginger oleoresin microcapsules ultrasonic vacuum drying

[0049] Take fresh ginger, peel and wash it, bake it at 60°C for 8 hours, with a moisture content of 6.57%, act with ethanol for 1 hour, filter, evaporate to dryness in a water bath at 50°C, and dry it in a vacuum oven to obtain the core material ginger oil Resin, wherein the active ingredient is gingerol, with a content of 4.6%.

[0050] 100g of microcapsules contains 90g of wall material, add 8g of alginate and 82g of octenyl succinic acid starch ester (n-OSA starch) into 300ml of distilled water to soak and swell, heat the distilled water to 90°C, stir to dissolve, and cool to 60°C ℃.

[0051] Add emulsifier Tween60 and Span60 composite system 2g in core material ginger oleoresin, the ratio of Tween60 and Span60 is 52%: 48%, emulsion 12ml is added in the wall material solution, put and stir on the constant temperature water bath, stirring speed 700r / min, forming a mixed emulsion of core and wal...

Embodiment 2

[0055] Embodiment 2: high temperature spray drying of ginger oleoresin microcapsules

[0056] In the spray drying process, the inlet air temperature is 170°C, the outlet air temperature is 80°C, and the flow rate is 500L / h.

[0057] Take fresh ginger, peel and wash it, bake it at 60°C for 8 hours, with a moisture content of 6.57%, act with ethanol for 1 hour, filter, evaporate to dryness in a water bath at 50°C, and dry it in a vacuum oven to obtain the core material ginger oil Resin, wherein the active ingredient is gingerol, with a content of 4.6%.

[0058] 100g of microcapsules contains 90g of wall material, add 8g of alginate and 82g of octenyl succinic acid starch ester (n-OSA starch) into 300ml of distilled water to soak and swell, heat the distilled water to 90°C, stir to dissolve, and cool to 60°C ℃.

[0059] Add emulsifier Tween60 and Span60 composite system 2g in core material ginger oleoresin, the ratio of Tween60 and Span60 is 52%: 48%, emulsion 12ml is added in ...

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Abstract

The invention discloses a microcapsule production technology including five steps of preparation of a wall material solution, emulsification mixing of a core material and a wall material, ultrasonic embedding, homogeneous dispersion and micro capsule spray drying. The preparation technology has the advantages of simple operation, selection of the reasonable wall materials such as octenyl succinic starch ester, seaweed gum, carrageenan and the like, easily obtained raw materials, wide scope of application, safe and reliable use, capability of well preventing the volatilization, oxidation or inactivation of instable raw materials, and effectively preventing the release of the core material, by selection of a suitable emulsifier and stirring speed, the micro capsule embedding rate is improved; microcapsule is prepared by spray drying method, and the microcapsule production technology is high in production capacity, simple in technology, and suitable for continuous industrial and automatic production.

Description

【Technical field】 [0001] The invention relates to the technical field of medicine production technology, in particular to the technical field of a microcapsule production technology. 【Background technique】 [0002] Microcapsule refers to a polymer shell and a micro container or package. In recent years, some experts have also classified microcapsules into capsules. Microcapsules refer to the use of natural or synthetic polymer materials to wrap medicine powder particles or medicine liquid droplets into tiny capsules with a diameter of 1-5000 μm. The technique is called microencapsulation and the product is called microcapsules. [0003] Microcapsules are small spherical vesicles with a certain degree of permeability. The outer layer is a semipermeable membrane, and the inner layer is a liquid core, which is composed of a core material and a wall material. The significance of microencapsulation lies in: ①It can effectively reduce the reactivity of external environmental fac...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J13/02B01J13/04A61J3/07
CPCB01J13/02A61J3/07B01J13/025B01J13/043
Inventor 潘苏枫
Owner ZHEJIANG CHUNBAO CAPSULES
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