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Compound ivermectin injection and preparation method thereof

A technology of ivermectin and injection, which is applied in the field of compound ivermectin injection and its preparation, can solve the problems of no research reports and no products on the market, and achieve controllable process conditions, improved anti-insect effect, and small dosage Effect

Inactive Publication Date: 2015-01-28
JIANGXI NUCLEAR IND TIANDIHE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The data search also shows that there is no research report on this preparation, and no product is on the market. Therefore, the research invention of this preparation has the basic attributes of an invention patent

Method used

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  • Compound ivermectin injection and preparation method thereof
  • Compound ivermectin injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Prescription: ivermectin 5g, mebendazole 20g, levamisole hydrochloride 5g, propylene glycol 300ml, thiourea 2g, ethanol to 1000ml.

[0016] Process steps: Take the prescribed amount of propylene glycol and appropriate amount of ethanol, heat to 60-80°C, add the prescribed amount of ivermectin, levamisole hydrochloride and mebendazole in sequence to dissolve, then add the prescribed amount of thiourea to dissolve, add The remaining amount of ethanol to the full amount; the relative content of ivermectin, mebendazole and levamisole hydrochloride in the national inspection should meet the specified requirements, otherwise adjust with ivermectin, mebendazole and levamisole hydrochloride or organic solvents; filter, potting ; Sterilize at 100°C for 30 minutes.

Embodiment 2

[0018] Prescription: ivermectin 10g, mebendazole 40g, levamisole hydrochloride 10g, glycerin formal 500ml, vitamin C 5g, L-semicarpine hydrochloride 5g, glycerin to 1000ml.

[0019] Process steps: Take the prescribed amount of glycerin methylal and an appropriate amount of glycerin, heat to 60-80°C, add the prescribed amount of ivermectin, levamisole hydrochloride and mebendazole in sequence to dissolve, then add the prescribed amount of vitamin C, L -Semilight amine hydrochloride, make it dissolve, add the remaining amount of glycerin to the full amount; the relative content of ivermectin, mebendazole and levamisole hydrochloride in the inspection should meet the specified requirements, otherwise use ivermectin, mebendazole and levamisole hydrochloride Adjust with imidazole or organic solvent; filter, pot; sterilize at 100°C for 30 minutes.

Embodiment 3

[0021] Prescription: ivermectin 20g, mebendazole 80g, levamisole hydrochloride 20g, 2-pyrrolidone 400ml, anhydrous sodium sulfite 2g, sodium formaldehyde sulfoxylate 4g, dimethylformamide added to 1000ml.

[0022] Process steps: Take the prescribed amount of 2-pyrrolidone and an appropriate amount of dimethylformamide, heat it to 60-80°C, add the prescribed amount of ivermectin, levamisole hydrochloride and mebendazole in sequence to dissolve, and then add the prescribed amount of no Dissolve sodium sulfite and sodium formaldehyde sulfoxylate in water, and add the remaining amount of dimethylformamide to the full amount; the relative content of ivermectin, mebendazole and levamisole hydrochloride in the national inspection should meet the specified requirements, otherwise use ivermectin , mebendazole and levamisole hydrochloride or organic solvent to adjust; filter, potting; sterilize at 100°C for 30 minutes.

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Abstract

The present invention discloses a composing prescription of a compound ivermectin injection and a preparation method of the compound ivermectin injection, and belongs to the veterinary medicine technology. The compound ivermectin injection comprises main drugs, a solvent and an antioxidant so as to prepare the stable high-concentration compound ivermectin injection. The injection has characteristics of advanced technology, good stability, broad spectrum, high efficiency, low irritation on the injected site, easy use, and clinical efficiency superior to the single-formula injection. According to the present invention, the raw materials comprise 0.5-5.0% of ivermectin, 2-20.0% of mebendazole, 0.5-5.0% of levamisole hydrochloride, 0.1-1% of the antioxidant, and the balance of the solvent, wherein the antioxidant is one or a mixture selected from thiourea, L-cysteamine hydrochloride, vitamin C, ethylenediamine, sodium hydrogen sulfite, anhydrous sodium sulfite, sodium formaldehydesulfoxylate dihydrate, sodium metabisulfite and the like, and the solvent is one or a mixture selected from propylene glycol, ethanol, glycerol, glycerol formal, dimethylformamide, dimethylacetamide, 2-pyrrolidone and the like.

Description

technical field [0001] The invention relates to a compound ivermectin injection and a preparation method thereof. Background technique [0002] Ivermectin: Ivermectin is a new type of broad-spectrum, high-efficiency, small dosage, and low-toxicity antibiotic antiparasitic drug. It has a good killing effect on internal and external parasites, especially nematodes and arthropods. , trematodes and protozoa (such as whipworms) are invalid. The repellent effect of ivermectin on nematodes and arthropods lies in increasing the release of the inhibitory transmitter γ-aminobutyric acid (GABA) in the worm body, opening the Cl ion channel controlled by glutamate, and enhancing the neuromembrane’s response to Cl. Permeability, thereby blocking the transmission of nerve signals, and eventually nerve paralysis, causing muscle cells to lose their ability to contract, resulting in the death of the worm. Ivermectin is widely used in gastrointestinal nematodes, lung nematodes and parasitic ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61K9/08A61P33/00A61P33/10A61P33/14A61K31/4184A61K31/429
CPCA61K31/7048A61K9/08A61K31/4184A61K31/429A61K2300/00
Inventor 李龙瑞周奀忠孔晟张吉鹍汪卫平罗灵廖海兵邵智军李检香
Owner JIANGXI NUCLEAR IND TIANDIHE PHARMA
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