Compound ivermectin injection and preparation method thereof
A technology of ivermectin and injection, which is applied in the field of compound ivermectin injection and its preparation, can solve the problems of no research reports and no products on the market, and achieve controllable process conditions, improved anti-insect effect, and small dosage Effect
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Embodiment 1
[0015] Prescription: ivermectin 5g, mebendazole 20g, levamisole hydrochloride 5g, propylene glycol 300ml, thiourea 2g, ethanol to 1000ml.
[0016] Process steps: Take the prescribed amount of propylene glycol and appropriate amount of ethanol, heat to 60-80°C, add the prescribed amount of ivermectin, levamisole hydrochloride and mebendazole in sequence to dissolve, then add the prescribed amount of thiourea to dissolve, add The remaining amount of ethanol to the full amount; the relative content of ivermectin, mebendazole and levamisole hydrochloride in the national inspection should meet the specified requirements, otherwise adjust with ivermectin, mebendazole and levamisole hydrochloride or organic solvents; filter, potting ; Sterilize at 100°C for 30 minutes.
Embodiment 2
[0018] Prescription: ivermectin 10g, mebendazole 40g, levamisole hydrochloride 10g, glycerin formal 500ml, vitamin C 5g, L-semicarpine hydrochloride 5g, glycerin to 1000ml.
[0019] Process steps: Take the prescribed amount of glycerin methylal and an appropriate amount of glycerin, heat to 60-80°C, add the prescribed amount of ivermectin, levamisole hydrochloride and mebendazole in sequence to dissolve, then add the prescribed amount of vitamin C, L -Semilight amine hydrochloride, make it dissolve, add the remaining amount of glycerin to the full amount; the relative content of ivermectin, mebendazole and levamisole hydrochloride in the inspection should meet the specified requirements, otherwise use ivermectin, mebendazole and levamisole hydrochloride Adjust with imidazole or organic solvent; filter, pot; sterilize at 100°C for 30 minutes.
Embodiment 3
[0021] Prescription: ivermectin 20g, mebendazole 80g, levamisole hydrochloride 20g, 2-pyrrolidone 400ml, anhydrous sodium sulfite 2g, sodium formaldehyde sulfoxylate 4g, dimethylformamide added to 1000ml.
[0022] Process steps: Take the prescribed amount of 2-pyrrolidone and an appropriate amount of dimethylformamide, heat it to 60-80°C, add the prescribed amount of ivermectin, levamisole hydrochloride and mebendazole in sequence to dissolve, and then add the prescribed amount of no Dissolve sodium sulfite and sodium formaldehyde sulfoxylate in water, and add the remaining amount of dimethylformamide to the full amount; the relative content of ivermectin, mebendazole and levamisole hydrochloride in the national inspection should meet the specified requirements, otherwise use ivermectin , mebendazole and levamisole hydrochloride or organic solvent to adjust; filter, potting; sterilize at 100°C for 30 minutes.
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