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Application of L-arabinose to preparation of medicine or health care products for preventing or curing hyperammonemia

A technology of arabinose and hyperammonemia, which is applied in the application field of medicine or health products, and can solve problems such as hyperammonemia that have not been found

Active Publication Date: 2015-01-21
唐传生物科技(厦门)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Existing studies have shown that L-arabinose has the effects of weight loss, lipid-lowering, blood sugar-lowering, laxative, etc.; but there is no relevant report on the use of L-arabinose for the prevention or treatment of hyperammonemia

Method used

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  • Application of L-arabinose to preparation of medicine or health care products for preventing or curing hyperammonemia
  • Application of L-arabinose to preparation of medicine or health care products for preventing or curing hyperammonemia
  • Application of L-arabinose to preparation of medicine or health care products for preventing or curing hyperammonemia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0009] The effect of reducing blood ammonia and endotoxin of L-arabinose will be further illustrated through experiments below.

[0010] 1. L-arabinose to CCl 4 Effect of blood ammonia in mice with liver injury

[0011] 1. Experimental materials and methods

[0012] 1.1 Drugs and reagents

[0013] L-arabinose (purity 99%): Tang Chuan Biotechnology (Xiamen) Co., Ltd., batch number: 1009081; Lactulose oral solution (66.7%): Beijing Hanmei Pharmaceutical Co., Ltd., batch number: 130457; blood ammonia determination kit, Nanjing Jiancheng Bioprocess Research Institute; Chromogenic Limulus Reagent Kit (quantitative detection of endotoxin), Xiamen Limulus Reagent Experimental Factory Co., Ltd.; the rest of the reagents are domestic analytical grade.

[0014] 1.2 Instruments

[0015] TGL-16R high-speed refrigerated centrifuge Zhuhai Heima Company; RT-9100 semi-automatic biochemical analyzer Shenzhen Leidu Life Science Co., Ltd.; electronic balance, Mettler-Toledo Instruments Shang...

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Abstract

The invention discloses the application of L-arabinose to the preparation of medicine or health care products for preventing or curing hyperammonemia, and particularly discloses the application of L-arabinose to the preparation of medicine or health care products for reducing blood ammonia and / or endotoxin. The applicant finds, in experiments, that L-arabinose can effectively reduce the level of blood ammonia and endotoxin of a mouse (1 to 4 grams / kg / day), and body health is not damaged while the function is achieved.

Description

technical field [0001] The present invention relates to the application of L-arabinose, in particular to the application of L-arabinose in the preparation of medicines or health care products for preventing or treating hyperammonemia. Background technique [0002] Hyperammonemia is due to the disturbance of the urea cycle in the body, which causes the ammonia produced by the decomposition of amino acids in the body and the ammonia absorbed by the intestines, which cannot be successfully synthesized into urea and excreted from the body, resulting in the accumulation of free ammonia in the body, forming hyperammonemia. Excessive ammonia in the body is neurotoxic, characterized by central nervous system dysfunction and metabolic disorders, and mental retardation, disturbance of consciousness, and nervous system signs as the main clinical manifestations. Hyperammonemia is mostly caused by liver damage. Hepatic encephalopathy is a syndrome of central nervous system dysfunction c...

Claims

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Application Information

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IPC IPC(8): A61K31/7004A61P3/00A61P31/00
Inventor 杨子明
Owner 唐传生物科技(厦门)有限公司
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