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Hydrocolloid patch containing panax notoginseng saponins and preparation method thereof

A technology of Panax notoginseng saponins and hydrocolloids, which is applied in the field of medicine, can solve the problems that have not yet been reported on hydrocolloid dressings for promoting healing, and achieve the effects of excellent drug release performance, high water absorption, and good adhesion performance

Active Publication Date: 2015-01-14
云南白药集团无锡药业有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, anti-inflammatory ingredients are often added to hydrocolloid excipients to expand its application range, and there are no reports of healing-promoting hydrocolloid dressings containing Panax notoginseng saponins

Method used

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  • Hydrocolloid patch containing panax notoginseng saponins and preparation method thereof
  • Hydrocolloid patch containing panax notoginseng saponins and preparation method thereof
  • Hydrocolloid patch containing panax notoginseng saponins and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] A hydrocolloid application containing Panax notoginseng saponins, which is composed of a backing layer, a drug-containing colloid layer and an anti-adhesive layer, and the drug-containing colloid layer is composed of the following components in parts by weight:

[0029]

[0030] The hydrocolloid application containing the total saponins of Panax notoginseng is obtained through the following steps:

[0031] (1) Weigh styrene-isoprene-styrene block copolymer, polyisobutylene, and antioxidant 1010 in proportion, add them to the reaction kettle to melt at 150°C and stir evenly, then add hydrogenated rosin resin and stir at 140°C until uniform Then transfer to the internal mixer, add the premixture of hydrophilic polymer and Panax notoginseng saponins, N 2 protection, 120°C banburying for 30min to obtain drug-containing colloid layer;

[0032] (2) Transfer the drug-containing colloid layer to a coating machine, coat it on the anti-adhesive layer PET film at 110°C, and co...

Embodiment 2-7

[0051] A hydrocolloid application containing Panax notoginseng saponins, which consists of a backing layer, a drug-containing colloid layer and an anti-adhesive layer. The components contained in the drug-containing colloid layer and the parts by weight of each component are shown in Table 2.

[0052] Table 2

[0053]

[0054] The hydrocolloid application containing the total saponins of Panax notoginseng is obtained through the following steps:

[0055] (1) Weigh styrene-isoprene-styrene block copolymer, polyisobutylene, and antioxidant 1010 in proportion, add them to the reaction kettle to melt at 160°C and stir evenly, then add hydrogenated rosin resin and stir at 110°C until uniform Then transfer to the internal mixer, add the premixture of hydrophilic polymer and Panax notoginseng saponins, N 2 protection, banburying at 140°C for 40 minutes to obtain a drug-containing colloid layer;

[0056] (2) Transfer the drug-containing colloid layer to a coating machine, coat it...

Embodiment 8-14

[0065] A hydrocolloid application containing Panax notoginseng saponins, which is composed of a backing layer, a drug-containing colloid layer and an anti-sticking layer. The components contained in the drug-containing colloid layer and the parts by weight of each component are shown in Table 4.

[0066] Table 4

[0067]

[0068] The hydrocolloid application containing the total saponins of Panax notoginseng is obtained through the following steps:

[0069] (1) Weigh styrene-isoprene-styrene block copolymer, polyisobutylene, and antioxidant 1010 in proportion, add them to the reaction kettle to melt at 155°C and stir evenly, then add hydrogenated rosin resin and stir at 130°C until uniform Then transfer to the internal mixer, add the premixture of hydrophilic polymer and Panax notoginseng saponins, N 2 protection, banburying at 110°C for 35 minutes to obtain a drug-containing colloid layer;

[0070] (2) Transfer the drug-containing colloid layer to a coating machine, and ...

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Abstract

The invention discloses a hydrocolloid patch containing panax notoginseng saponins and a preparation method thereof. The hydrocolloid patch is composed of a lining layer, a medicine-containing colloid layer and an anti-adhesion layer, and the hydrocolloid patch is prepared in the following manner: adding styrene-isoprene-styrene block copolymer, polyisobutene, mineral oil and an antioxidant into a reaction kettle, smelting at 150-160 DEG C, stirring uniformly, adding hydrogenated rosin resin, uniformly stirring at 110-140 DEG C to obtain an adhesive, transferring the adhesive into an internal mixer, adding a premix of a hydrophilic polymer and the panax notoginseng saponins, internally mixing at 110-140 DEG C for 30-40 min under N2 protection to obtain the medicine-containing colloid layer, transferring the medicine-containing colloid layer into a coating machine for coating, compounding and cutting, and adhering the medicine-containing colloid layer with the lining layer and the anti-adhesion layer to obtain the hydrocolloid patch. The hydrocolloid patch disclosed by the invention has excellent adhesion properties, drug release performance and high soakage, and can significantly improve the wound healing speed.

Description

technical field [0001] The invention relates to the technical field of medicines, in particular to a hydrocolloid plaster containing the extract of the traditional Chinese medicine Panax notoginseng-total saponins of Panax notoginseng and a preparation method thereof. Background technique [0002] The skin is the largest organ in the human body, covering the surface of the human body, and is the first barrier against physical, mechanical, chemical and pathogenic microorganisms. The skin often has wounds due to external mechanical damage. Wounds are prone to infection and necrosis under improper care or body disease, which seriously affects wound healing and even endangers life. Wound healing is divided into three stages: ①Inflammation-exudation stage : Inflammatory reaction with exudation of interstitial fluid; ②proliferative phase: hyperplasia of blood vessels and granulation tissue; ③repair phase: formation of new epithelial cells and wound healing. According to the wound...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/44A61L15/42A61L15/24A61L15/34A61L15/22A61L15/26A61L15/28A61K47/44A61K36/258A61K9/70A61P17/02
Inventor 宋长龙赵晓亮张士妍陆晔辉刘跃曹晓军邵瑜霍玉平贾永锋
Owner 云南白药集团无锡药业有限公司
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