Mixed gel of polylactic acid microspheres and cross-linked hyaluronic acid for injection and preparation method of mixed gel

Abstract

The invention relates to a mixed gel of polylactic acid microspheres and cross-linked hyaluronic acid for injection and a preparation method of the mixed gel. The polylactic acid microspheres have the molecular weight of 15000-120000 and the average particle size of 10-150mu m, and the mass fraction of the polylactic acid microspheres in the mixed gel is 5-25%; a salt solution of the cross-linked hyaluronic acid gel is obtained by swelling and balancing the cross-linked hyaluronic acid gel in a sodium chloride solution or a phosphate buffer solution with the osmotic pressure of 250-350mOsmol / L and the pH value of 6.5-7.5; the cross-linked hyaluronic acid gel is a hyaluronic acid gel cross-linked by divinyl sulfone or glycidyl ether. A mixed gel product of polylactic acid and cross-linked hyaluronic acid, obtained by directly mixing the polylactic acid microspheres with the cross-linked hyaluronic acid gel obtained by swelling and balancing in the salt solution is uniform, fine, long in partial retention time, good in plasticity and few in side effects, has an obvious effect on eliminating wrinkles, and has few operation steps and stable product quality.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to a mixed gel of polylactic acid microspheres and cross-linked hyaluronic acid for injection and a preparation method thereof. Background technique [0002] In recent years, injectable gels for cosmetic or medical purposes have developed rapidly. Injectable gels can achieve minimally invasive treatment or filling cosmetic effects at the injection site, and have attracted widespread attention. However, in order to achieve the above goals, higher requirements are put forward for the materials used as injectable gels. Compared with animal-derived materials, artificial chemically synthesized polymer materials are safe to use because they reduce the risk of infection and disease. Its scope of use is gradually expanding, but synthetic polymer materials should have good biocompatibility and biodegradability before they can be used in hybrid gels. [0003] Patent 200810009190.8 discloses a suspensi...

AI Technical Summary

Problems solved by technology

[0003] Patent 200810009190.8 discloses a suspension of hyaluronic acid or its salt containing macromolecular hydrogel for injection and its preparation method, but its macromolecule is a single-component cross-linked polysaccharide compound or polymer, and the therapeutic effect is not good. Obvious, and hyaluronic acid is easy to diffuse in the body and be degraded by enzymes in body tissues, the retention time is short, and it cannot achieve long-term beauty effects

Patent 200810009193.1 discloses a mixed gel for injection and its preparation method. The preparation process is cumbersome, and hyaluronic acid or its salt is used as a solvent, which has a short retention time in the body and cannot achieve long-term beauty effects.