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Preparation method and applications of molecular imprinting composite membrane

A molecular imprinting and composite membrane technology, applied in the preparation of organic compounds, the preparation of carboxylate esters, chemical instruments and methods, etc., can solve the problems of efficient selective separation, inability to separate single substances, and inability to single, etc. Adsorption and selectivity, the effect of superior p-hydroxybenzoic acid molecular recognition performance

Inactive Publication Date: 2014-12-24
JIANGSU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are still some factors that limit the development of traditional membrane separation technology. For example, the current commercially available membranes (ultrafiltration, microfiltration and reverse osmosis membranes) can only achieve the separation of a certain type of substance and cannot separate a single substance. For organic compounds with similar structures, traditional membranes cannot perform single and efficient selective separation of certain substances

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] (1) Take 0.12 g polyvinylidene fluoride microfiltration membrane (PVDF) and place it in 20 mL aqueous solution containing 0.56 g potassium hydroxide and 0.1 g potassium dichromate, react at 55 °C for 1.5 hours, take it out, and wash it with distilled water After several times, soak the membrane in 20 mL aqueous solution containing 0.24 g sodium bisulfite for 20 min, clamp the membrane out, wash with distilled water until neutral, rinse with ethanol and dry to obtain a PVDF membrane with surface hydroxylation .

[0032] (2) Place the PVDF membrane treated in step (1) in a 100 mL Erlenmeyer flask, add 1.5 mL 3-aminopropyltriethoxysilane (KH-550) and 20 mL toluene, and add 2 Drop triethylamine, pass nitrogen for 5 minutes, seal it, shake it in a water bath at 70°C for 8 hours, take out the membrane, wash it with ethanol for 30 minutes, and dry it for later use.

[0033] (3) Place the PVDF membrane treated in step (2) in a 100 mL Erlenmeyer flask, add 1 mL of pyridine, 1.5...

Embodiment 2

[0044] (1) Take 0.12 g of polyvinylidene fluoride microfiltration membrane (PVDF) and place it in 20 mL of aqueous solution containing 0.56 g of potassium hydroxide and 0.15 g of potassium dichromate, react at 60°C for 1 hour, take it out, and wash it with distilled water After cleaning several times, soak the membrane in 20 mL of aqueous solution containing 0.24 g of sodium bisulfite for 20 min, clamp the membrane out, wash with distilled water until neutral, rinse with ethanol and dry to obtain surface hydroxylated PVDF membrane.

[0045] (2) Place the PVDF membrane treated in step (1) in a 100 mL Erlenmeyer flask, add 1.8 mL 3-aminopropyltriethoxysilane (KH-550) and 20 mL toluene, and add dropwise 4 drops of triethylamine, sealed with nitrogen for 5 minutes, shaken in a 70°C water bath for 8 hours, took out the membrane, soaked it in ethanol for 30 minutes, and dried it for later use.

[0046] (3) Place the PVDF membrane treated in step (2) in a 100 mL Erlenmeyer flask, ad...

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Abstract

The invention relates to a preparation method and applications of a molecular imprinting composite membrane. The invention relates to a method for removing p-hydroxybenzoic acid from acetylsalicylic acid, and particularly relates to a method for synthesizing p-hydroxybenzoic acid composite imprint microfiltration membrane through taking commercial organic membrane polyvinylidene difluoride membrane (PVDF) as a substrate, 3-aminopropyltriethoxysilane (KH-550) and pyridine as membrane modifiers, impurity p-hydroxybenzoic acid (p-HB) in acetylsalicylic acid as a template molecule, 4-vinylpyridine (4-VP) as a functional monomer, N,N'-methylenebisacrylamide (MBAA) as a cross-linking agent, azodiisobutyronitrile (AIBN) as an initiator and methanol as a pore-forming agent. A static adsorption experiment is used for researching the adsorption balance, dynamics and selective recognition performances of the prepared composite imprinting microfiltration membrane. Results show that the p-hydroxybenzoic acid composite imprint microfiltration membrane obtained by adopting the method has excellent recognition performance on the p-hydroxybenzoic acid molecules.

Description

technical field [0001] The invention belongs to the technical field of material preparation and separation, in particular to a method for preparing a molecularly imprinted composite membrane and its application in separating p-hydroxybenzoic acid from acetylsalicylic acid. Background technique [0002] Aspirin, also known as acetylsalicylic acid, is a commonly used analgesic, which can be used as an antipyretic, analgesic, anti-inflammatory, anti-rheumatic and anti-platelet aggregation drug. For fever (cold, flu, etc.), pain (headache, toothache, neuralgia, muscle pain, dysmenorrhea, etc.), rheumatism (rheumatoid arthritis, rheumatoid arthritis), and prevention of transient ischemic attacks, Thrombosis after myocardial infarction or other surgery. The production of acetylsalicylic acid often contains paraben as an impurity. p-Hydroxybenzoic acid is a widely used raw material for organic synthesis. It is also widely used in food, cosmetics, medicine antisepsis, antifungal ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J9/40B01D71/34B01D69/12C07C69/157C07C67/56
Inventor 季燕军戴晓晖孟敏佳闫永胜
Owner JIANGSU UNIV
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