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Visual minimally-invasive intracranial dosing device

An internal drug delivery, U-shaped technology, applied in the field of visual minimally invasive intracranial drug delivery device, can solve the problems of inaccuracy, damage to the brain, easy infection, etc., and achieve the effects of accurate positioning, minor damage, and accurate quantitative

Inactive Publication Date: 2014-12-24
SHANXI MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The present invention mainly aims at the problems of easy infection, brain damage and invisible, unintuitive and inaccurate drug dosage in traditional drug administration, and provides a convenient and simple visual microscope with accurate positioning, accurate quantification, intuitive visualization, slight damage invasive intracranial drug delivery device

Method used

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  • Visual minimally-invasive intracranial dosing device
  • Visual minimally-invasive intracranial dosing device
  • Visual minimally-invasive intracranial dosing device

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Such as figure 1 , figure 2 As shown, a visible minimally invasive intracranial drug delivery device includes a U-shaped base 1, an ear bar 2 is provided on both sides of the open end of the U-shaped base 1, and an adapter 3 is provided at the closed end of the U-shaped base 1. An incisor clip 4 is provided at the front end of the adapter 3, an X arm 5, a Y arm 6 and a Z arm 7 are provided on the side wall of the U-shaped base 1, and a holder 8 is provided on the X arm 5, wherein: also includes a guide Liquid tube 9, a micro injection pump 10 is installed at one end of the catheter tube 9, a fixed needle 11 is installed at the other end of the catheter tube 9, a capillary quartz tube 12 is installed on the fixed needle 11, and outside the capillary quartz tube 12 The surface is marked with a scale 13, and the outer surface of the catheter 9 is also marked with a scale 13. The catheter 9, the fixed needle 11 and the capillary quartz tube 12 are connected, and the inner...

Embodiment 2

[0015] Medial septum of rat basal ganglia (medial septum, MS):

[0016] To inject 1 μl of drug (such as pontamine blue) into the medial septum of the basal ganglia of an adult SD rat:

[0017] First fill the minimally invasive administration needle with physiological saline, connect the end of the catheter to the micro-injection pump, first suck 0.5 μl of air, and then suck 1 μl of pentamine sky blue. Adult SD rats were anesthetized with chloral hydrate or urethane, fixed on a stereotaxic apparatus 6, and the skull was exposed after hair clipping and disinfection. After drilling the skull 0.7mm behind the anterior bregma and 2mm laterally, slowly insert the fixed minimally invasive drug delivery needle 6mm into the brain. Inclined 18°. The administration was performed by adjusting the administration rate of the microsyringe pump to 0.1 μl / min. see results image 3 :exist image 3 In , the darker area in the middle and lower part of the figure is the medial septum of the r...

Embodiment 3

[0019] Administration of rat hippocampus

[0020] To inject 1 μl of drug (such as pontamine sky blue) into the hippocampal nuclei of an adult SD rat:

[0021] First fill the minimally invasive administration needle with physiological saline, connect the tail end to the micro-injection pump, first suck 0.5 μl of air, and then suck 1 μl of pentamine sky blue. Adult SD rats were anesthetized with chloral hydrate or urethane, fixed on a stereotaxic apparatus, and the skull was exposed after hair clipping and disinfection. After the skull was drilled 3.0mm behind the anterior bregma and 2.2mm laterally, the fixed minimally invasive drug delivery needle was slowly inserted 3.0mm into the cranium. The administration was performed by adjusting the administration rate of the microsyringe pump to 0.1 μl / min. see results Figure 4 :exist Figure 4 In , the brighter area in the lower part of the figure is the hippocampus of the rat. The capillary quartz tube 12 is a dark thin line, a...

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Abstract

The invention belongs to the technical field of medical equipment, and particularly relates to a visual minimally-invasive intracranial dosing device. The visual minimally-invasive intracranial dosing device mainly aims to solve the problems of easiness in infection, damage to brains, non-visuality and non-intuition of liquor and inaccuracy in dosage of traditional dosing. The invention adopts the technical scheme that the visual minimally-invasive intracranial dosing device comprises a U-shaped base and a liquid guide tube, wherein two ear rods are respectively arranged on two sides of the open end of the U-shaped base, an adapter is arranged on the close end of the U-shaped base, a fore-tooth clamp is arranged on the front end of the adapter, an X arm, a Y arm and a Z arm are arranged on the side wall of the U-shaped base, a clamper is arranged on the X arm, a micro-injection pump is installed on one end of the liquid guide tube, a fixed pin is installed on the other end of the liquid guide tube, a capillary quartz tube is installed on the fixed pin, and scales are marked on the outer surface of the capillary quartz tube. The visual minimally-invasive intracranial dosing device has the advantages of accuracy in positioning, precision in quantifying, intuition, visuality, microtrauma, convenience and simplicity.

Description

technical field [0001] The invention belongs to the technical field of medical equipment, and in particular relates to a visible minimally invasive intracranial drug delivery device. Background technique [0002] Intracranial nuclei administration is an important means to study the function of brain nuclei and target the treatment of brain diseases. This way of administration does not have the problems of blood-brain barrier and first-pass effect, and it is convenient to observe the direct effect of the drug on the central nervous system. Traditional methods of administration include implantation and direct administration. Although intracranial drug injections can be repeated multiple times for drug administration through buried tubes, problems of infection and falling off of buried tubes are unavoidable. Direct administration is usually administered with a microinjection needle. The cranial parts of these drug delivery devices are relatively thick, and when injecting dru...

Claims

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Application Information

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IPC IPC(8): A61M31/00
Inventor 张升校祁金顺张军马小雯李玉峰张雨薇郭静蕙姜涛郭云飞蔡红艳原丽王昭君武美娜仝嘉庆郝明杨菊石辉韩宇飞
Owner SHANXI MEDICAL UNIV
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