A self-breathing device for animals using hyperpolarized gas MRI

Abstract

The invention discloses an animal autonomous respiration device used for hyperpolarization gas MRI. A respiration connector is respectively connected with an existing hyperpolarization gas transmission module and an MRI compatible respirator. The respiration connector is directly connected with a respiration cavity through a respiration pipeline, a pressurization cavity is directly connected with the respiration cavity through a perforated diaphragm, the pressurization cavity is connected with the outer diameter of the respiration pipeline, a normal pressure baffle is provided with vent holes, the normal pressure baffle is connected with the tail end of the respiration cavity, an anesthetic gas recovery box is connected with the outer diameter of the pressurization cavity and the normal pressure baffle, an anesthetic gas inlet pipeline is sequentially connected with a flow meter and a pressure meter, and the pressure meter is connected with the pressurization cavity through a pipeline. A branch is formed between the flow meter and the pressure meter through a three-way valve, and the branch is directly connected with the MRI compatible respirator. The animal autonomous respiration device used for hyperpolarization gas MRI is simple in structure, is convenient to use, achieves hyperpolarization gas tests, provides an autonomous respiration mode, avoids damage to the lungs of animals caused by a passive mechanical respiration mode, and guarantees authenticity and reliability of measuring results.

Description

technical field [0001] The present invention relates to the technical field of hyperpolarized gas delivery process, animal anesthesia and lung physiological state, and more specifically relates to a self-breathing device compatible with hyperpolarized gas delivery system, which is suitable for hyperpolarized gas in animal lungs Magnetic resonance imaging (MRI) studies. Background technique [0002] In my country, the incidence and per capita disease burden of lung diseases remain high, which has become a very serious public health and social problem. It is urgent to develop some effective methods for early diagnosis and treatment of major lung diseases. Currently commonly used lung imaging methods include X-ray chest X-ray, CT, PET-CT, etc. These methods are radioactive and cannot visualize the gas exchange function of the lungs. MRI has ultra-high resolution for soft tissues, and is very advantageous in brain, muscle, and nerve imaging. The low proton density and multi-cav...

AI Technical Summary

Problems solved by technology

If the same animal is subjected to two consecutive experiments, it will cause the animal to wait for most of the time. If the experimental animal is provided with gas anesthesia by using mechanical breathing for such a long time, it will cause changes in the shape and function of the experimental animal's lungs. change, causing the results obtained in the second test to be untrue and accurate

In order to protect the lung function of animals during the test and ensure the accuracy and repeatability of the test, a ventilation method that can protect the lung function of intubated animals during the MRI process and the interval between MRIs is needed, and the current device cannot meet the requirements. This requirement does not take into account multiple hyperpolarized gas MRI procedures

Images