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Preparation method of copper ion-mediated anticoagulant coating with in-situ catalytic NO release function

An in-situ catalysis, copper ion technology, applied in the field of biomedical engineering functional materials, can solve the problems of difficult to effectively control the copper ion loading, complex preparation process, etc., to achieve excellent scavenging of oxygen free radicals, high research and application value, excellent Antioxidant effect

Active Publication Date: 2016-08-17
GUANGZHOU NANCHUANG EVEREST MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Existing methods for loading copper ions include pulling method, dip coating method and ion exchange method, etc. Some of these methods have complex preparation processes, especially the loading amount of copper ions is difficult to effectively control

Method used

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  • Preparation method of copper ion-mediated anticoagulant coating with in-situ catalytic NO release function
  • Preparation method of copper ion-mediated anticoagulant coating with in-situ catalytic NO release function
  • Preparation method of copper ion-mediated anticoagulant coating with in-situ catalytic NO release function

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] A method for preparing an anticoagulant coating mediated by copper ions with in-situ catalytic NO release function, obtained by the following steps:

[0029] A. Polish, clean and dry the medical stainless steel material that needs to be modified;

[0030] B. Place the sample obtained in step A in a buffer system (acetic acid-acetate buffer) with pH=4, then add dopamine with a concentration of 0.01 mg / ml, collagen with a concentration of 0.01 mg / ml and a concentration of 0.01 mg / ml to the system. 0.01mg / ml CuCl 2 Solution, react at 10°C for 0.5h;

[0031] C. For the sample obtained in step B, immerse it in deionized water, clean it ultrasonically for 3 times, each time for 5min, and then wash it in N 2 The target material can be obtained by drying under the conditions.

Embodiment 2

[0033] A method for preparing an anticoagulant coating mediated by copper ions with in-situ catalytic NO release function, obtained by the following steps:

[0034] A. Polish, clean and dry the nickel-titanium alloy material that needs to be modified;

[0035] B, the sample obtained in step A is placed in a buffer system (Tris-HCl buffer) of pH=7, and then adding epigallocatechin gallate (EGCG) with a concentration of 10 mg / ml to the system, the concentration is 10 mg / ml ml of polyethyleneimine and CuSO at a concentration of 5 mg / ml 4 Solution, react at 30°C for 24h;

[0036] C. For the sample obtained in step B, immerse it in deionized water, clean it ultrasonically for 3 times, each time for 5min, and then wash it in N 2 The target material can be obtained by drying under the conditions.

Embodiment 3

[0038] A method for preparing an anticoagulant coating mediated by copper ions with in-situ catalytic NO release function, obtained by the following steps:

[0039] A. Polish, clean and dry the cobalt-based alloy that needs to be modified;

[0040] B. Place the sample obtained in step A in a buffer system (acetic acid-acetate buffer) with pH=5, and then add epicatechin gallate (ECG) with a concentration of 2 mg / ml to the system at a concentration of 3 mg / ml of butanediamine and a concentration of 1mg / ml of CuCl 2 Solution, at 15°C, react for 4h;

[0041] C. For the sample obtained in step B, immerse it in deionized water, clean it ultrasonically for 3 times, each time for 5min, and then wash it in N 2 The target material can be obtained by drying under the conditions.

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Abstract

The invention discloses a method for preparing an anticoagulant coating mediated by copper ions and having the function of in-situ catalyzing NO release. The steps include configuring an acidic buffer solution, and adding a certain concentration of a compound having an ortho-phenol structure, a compound having an amino group or a mercapto group, and a soluble salt of copper ions. The method of the invention has the advantages of simple operation, mild and easy reaction conditions, controllable content of compound component units with polyamino groups or mercapto groups in the prepared coating material, and easy regulation and control of copper ion loading. The modified coating prepared by the method of the present invention has excellent adhesion to the base material, and through the interaction between the copper ions in the coating and the blood, the NO donor molecules in the blood can be catalyzed in situ to continuously decompose and release NO molecules, thereby Realize the functions of inhibiting the activation and aggregation of platelets, inhibiting the proliferation and migration of smooth muscle cells and protecting the vascular endothelial layer.

Description

technical field [0001] The invention relates to biomedical engineering functional materials, especially the technical field of preparation of excellent anticoagulant materials. Background technique [0002] After the cardiovascular material is implanted into the human body, plasma proteins will first adhere to the surface of the material, and the adhered fibrinogen, von Willebrand factor, etc. will then trigger the attachment and activation of platelets on the surface of the material, and release various coagulation factors, and then Formation of blood clots. Therefore, the anticoagulant problem of blood-contact materials, such as vascular stents, artificial blood vessels, artificial heart valves, inferior vena cava filters, etc., is a permanent subject of research in the field of biomaterials. The development of materials with excellent anticoagulant properties is also the basic requirement and goal for long-term and stable service of blood-contact materials. Among the ma...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L33/02A61L33/04A61L33/00A61L33/06
Inventor 王进罗日方刘玉洁黄楠申方瑜赵元聪冷永祥陈俊英
Owner GUANGZHOU NANCHUANG EVEREST MEDICAL TECH CO LTD
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