New use of Rosaceae Malus plant or its extract

The technology of plant extract and apple genus is applied in the field of preparing medicines for improving insulin resistance, which can solve the problems of aggravating insulin resistance and the like, and achieve the effects of improving insulin resistance and clear drug effect.

Inactive Publication Date: 2014-12-17
SICHUAN ACAD OF CHINESE MEDICINE SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, since high blood sugar can exacerbate insulin resistance, other measures to lower blood sugar may also reduce insulin resistance

Method used

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  • New use of Rosaceae Malus plant or its extract
  • New use of Rosaceae Malus plant or its extract
  • New use of Rosaceae Malus plant or its extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Take 1000g of Begonia variegata, cut into granules, add water to extract three times, each time 10 times the amount of water, extract for 1 hour, combine the three water extracts, and concentrate into an extract.

Embodiment 2

[0037] Take 1000g of Begonia variegata, cut into granules, add 70% ethanol to take three times, each time 10 times the amount, extract for 1 hour, combine three alcoholic extracts, and concentrate into an extract.

Embodiment 3

[0039] The crabapple extract obtained in Examples 1 and 2, or other methods known to those skilled in the art, such as water extraction and alcohol precipitation or alcohol extraction, is made into an extract, and then purified by macroporous resin adsorption to obtain Crabapple. The extract is prepared by adding appropriate excipients according to the conventional preparation method to prepare the extract capsule of Begonia variegata.

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PUM

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Abstract

The invention provides a use of Rosaceae Malus plant or its extract in the preparation of insulin resistance improvement medicines. The invention also provides a medicinal composition for improving the insulin resistance. The medicine can improve the insulin resistance, can be used for preventing or / and treating insulin resistance syndromes, can be used in medicines for preventing or / and treating a group of clinic syndromes characterized by insulin resistance, comprising abnormal glucose metabolism, hypertension, lipid metabolism disorder, abdominal or visceral obesity, atherosclerosis, coronary heart disease, polycystic ovary syndrome, fibrinogen increase, fibrinolytic activity reduction, microalbuminuria, hyperuricemia and hyperleptinemia, and has clear medicine effects.

Description

technical field [0001] The present invention relates to the new application of Rosaceae Malus plant or its extract, in particular, the application in the preparation of medicines for improving insulin resistance. Background technique [0002] Insulin resistance (IR) refers to the decreased sensitivity of the target organs of insulin action (mainly liver, muscle and fat, and now it is believed that vascular endothelial cells and arterial smooth muscle cells are also insulin-sensitive cells), that is, normal A state in which a dose of insulin produces a subnormal biological effect. In the early and middle stages, in order to overcome insulin resistance, the body often secretes excessive insulin compensatoryly, causing hyperinsulinemia (hyperinsulinemia), so hyperinsulinemia is an important symbol of insulin resistance. There are many causes of IR, including genetic factors or primary insulin resistance, such as structural abnormalities of insulin, the presence of insulin anti...

Claims

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Application Information

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IPC IPC(8): A61P3/04A61P15/08A61P9/12A61P13/12A61P3/06A61K36/73A61P19/06A61P9/10A61P3/10A61P7/00A61P5/50
Inventor 赵军宁华桦杨安东朱宁
Owner SICHUAN ACAD OF CHINESE MEDICINE SCI
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