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Modification method for improving corrosion resistance and surface functionalization of biomedical magnesium-based metal material

A surface functionalization, magnesium-based metal technology, applied in the field of biomedical engineering functional materials, can solve problems such as excessive degradation, achieve high research and application value, hinder electron transfer, and excellent corrosion resistance

Inactive Publication Date: 2014-12-10
SOUTHWEST JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0002] Magnesium alloys are used in the biomedical field. Compared with traditional biomedical stainless steel, titanium alloys and other metal materials, magnesium alloys have the advantage of corrosion and degradation. However, due to their high chemical and electrochemical activities, they will be degraded too quickly in the physiological environment for a long time. the puzzle

Method used

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  • Modification method for improving corrosion resistance and surface functionalization of biomedical magnesium-based metal material
  • Modification method for improving corrosion resistance and surface functionalization of biomedical magnesium-based metal material
  • Modification method for improving corrosion resistance and surface functionalization of biomedical magnesium-based metal material

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Embodiment 1

[0030] A modification method for improving the corrosion resistance and surface functionalization of biomedical magnesium-based metal materials is obtained by the following steps:

[0031] A. Polish, clean and dry the pure magnesium material that needs to be modified;

[0032] B. Place the sample obtained in step A in a buffer system with pH=7, then add epigallocatechin gallate EGCG with a concentration of 0.5 mg / ml to the system, and react at 10°C for 1 hour;

[0033] C. For the sample obtained in step B, immerse it in deionized water, clean it ultrasonically for 3 times, each time for 5min, and then wash it in N 2 The target material can be obtained by drying under the conditions.

Embodiment 2

[0035] A modification method for improving the corrosion resistance and surface functionalization of biomedical magnesium-based metal materials is obtained by the following steps:

[0036] A. Polish, clean and dry the magnesium-zinc-manganese alloy material that needs to be modified;

[0037]B. Place the sample obtained in step A in a buffer system of pH=12, then add epigallocatechin gallate (EGCG) with a concentration of 10 mg / ml and selenocystamine with a concentration of 10 mg / ml to the system, At 30°C, react for 6h;

[0038] C. For the sample obtained in step B, immerse it in deionized water, clean it ultrasonically for 3 times, each time for 5min, and then wash it in N 2 The target material can be obtained by drying under the conditions.

Embodiment 3

[0040] A modification method for improving the corrosion resistance and surface functionalization of biomedical magnesium-based metal materials is obtained by the following steps:

[0041] A. Polish, clean and dry the WE43 magnesium alloy that needs to be modified;

[0042] B. Place the sample obtained in step A in a Tris-buffer buffer system with pH = 7, then add tannic acid with an o-phenolic hydroxyl structure with a concentration of 0.1 mg / ml into the system, and simultaneously add acetonitrile with a concentration of 1 mg / ml. Diamine, at 10°C, react for 1h;

[0043] C. For the sample obtained in step B, immerse it in deionized water, clean it ultrasonically for 3 times, each time for 5min, and then wash it in N 2 The target material can be obtained by drying under the conditions.

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Abstract

The invention discloses a modification method for improving corrosion resistance and surface functionalization of a biomedical magnesium-based metal material. The modification method for improving corrosion resistance and surface functionalization of the biomedical magnesium-based metal material comprises the following steps: preparing a Tris-buffer solution with a pH value of 7-12, adding a compound which has a certain concentration and is of a phenolic hydroxyl structure or also adding a compound which has a certain concentration and is of a multi-amino structure. The modification method for improving corrosion resistance and surface functionalization of the biomedical magnesium-based metal material is mild in reaction conditions, simple and easy to operate, relatively low in cost and favorable for after-treatment. The magnesium-based metal material prepared by the method and treated with modified coating has relatively excellent corrosion resistance; by virtue of introduction of different components, a plurality of reactive functional groups can be successfully introduced into the prepared material; the prepared material can be used for subsequent fixation of biological molecules (such as heparin, endothelial cell growth factor VEGF, various types of biological function protein and the like) or introduction of biological functions, is capable of exerting the corresponding biological functions and provides a novel research model for application of magnesium and magnesium alloys to cardiovascular materials.

Description

technical field [0001] The invention relates to biomedical engineering functional materials, in particular to the technical field of surface modification of biomedical degradable metal materials. Background technique [0002] Magnesium alloys are used in the biomedical field. Compared with traditional biomedical stainless steel, titanium alloys and other metal materials, magnesium alloys have the advantage of corrosion and degradation. However, due to their high chemical and electrochemical activities, they will be degraded too quickly in the physiological environment for a long time. problem. The surface of anti-corrosion materials with excellent performance has always been the means and purpose of the investigation of the function of magnesium-based biomedical materials. [0003] Using chemical conversion coating to treat magnesium alloy is an effective method to improve its corrosion resistance, and it is widely used because of its simple operation and low cost. The che...

Claims

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Application Information

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IPC IPC(8): C23C22/02
Inventor 王进罗日方张皓黄楠赵元聪万国江冷永祥陈思张江
Owner SOUTHWEST JIAOTONG UNIV
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