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Rubber material formula for medicine packaging rubber plugs

A technology of rubber material and encapsulation glue, applied in the field of rubber material formulation for medicine encapsulation rubber stopper, can solve the problems of poor safety in use, complicated process, difficult to prepare medical rubber products, etc., and achieves excellent mechanical properties and high chemical stability. Sex, formula design novel effect

Inactive Publication Date: 2014-12-03
ANHUI ZHONGMA RUBBER & PLASTIC PROD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Under the conditions of high temperature and high pressure, traditional medical rubber products tend to produce exudates and volatiles that pollute the human body and pharmaceuticals in their vulcanization system, making it difficult to prepare medical rubber products that meet the highest quality standards for pharmaceuticals
Existing medical rubber products and preparation methods thereof have complicated process, poor product environmental protection, weak use safety, and low service life

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] The formula of the rubber material for the drug packaging rubber plug is made of the following raw materials in parts by mass: 70 parts of butyl rubber, 10 parts of ethylene vinyl acetate copolymer, 8 parts of chitosan, 5 parts of hydroxypropyl methylcellulose, 2 parts of propolis, 1 part of kaolin, 1 part of titanium dioxide, 2 parts of nano diatomite, 0.5 parts of white oil, 0.5 parts of sorbic acid, 1 part of acetyl tri-n-butyl citrate, 1 part of sodium alginate, 0.5 parts of stearic acid 1 part, 1 part of zinc oxide, wherein the grade of nano-diatomaceous earth is food grade.

[0015] First add butyl rubber to the kneader, then add ethylene vinyl acetate copolymer, chitosan, hydroxypropyl methylcellulose, propolis, white oil, sorbic acid, and mix at 170-190°C under nitrogen. Refining for 1 hour, then cooling the kneader to 65-70°C, adding kaolin, titanium dioxide, nano-diatomaceous earth, acetyl tri-n-butyl citrate, sodium alginate, continuing to mix for 0.5 hours, ...

Embodiment 2

[0017] The formula of the rubber material for the medicine packaging rubber plug is made of the following raw materials in parts by mass: 80 parts of butyl rubber, 12 parts of ethylene vinyl acetate copolymer, 10 parts of chitosan, 6 parts of hydroxypropyl methylcellulose, 5 parts of propolis, 3 parts of kaolin, 2 parts of titanium dioxide, 2 parts of nano diatomite, 1 part of white oil, 1 part of sorbic acid, 2 parts of acetyl tri-n-butyl citrate, 2 parts of sodium alginate, 1 part of stearic acid 2 parts, 2 parts of zinc oxide, wherein the grade of nano diatomite is food grade.

[0018] First add butyl rubber to the kneader, then add ethylene vinyl acetate copolymer, chitosan, hydroxypropyl methylcellulose, propolis, white oil, sorbic acid, and mix at 170-190°C under nitrogen. Refining for 1 hour, then cooling the kneader to 65-70°C, adding kaolin, titanium dioxide, nano-diatomaceous earth, acetyl tri-n-butyl citrate, sodium alginate, continuing to mix for 0.5 hours, then di...

Embodiment 3

[0020] The formula of the rubber material for the medicine packaging rubber plug is made of the following raw materials in parts by mass: 90 parts of butyl rubber, 15 parts of ethylene vinyl acetate copolymer, 12 parts of chitosan, 8 parts of hydroxypropyl methylcellulose, 5 parts of propolis, 5 parts of kaolin, 3 parts of titanium dioxide, 3 parts of nano diatomite, 2 parts of white oil, 1.5 parts of sorbic acid, 4 parts of acetyl tri-n-butyl citrate, 3 parts of sodium alginate, 1 part of stearic acid parts, 2.5 parts of zinc oxide, wherein the grade of nano-diatomaceous earth is food grade.

[0021] First add butyl rubber to the kneader, then add ethylene vinyl acetate copolymer, chitosan, hydroxypropyl methylcellulose, propolis, white oil, sorbic acid, and mix at 170-190°C under nitrogen. Refining for 1 hour, then cooling the kneader to 65-70°C, adding kaolin, titanium dioxide, nano-diatomaceous earth, acetyl tri-n-butyl citrate, sodium alginate, continuing to mix for 0.5 h...

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Abstract

The invention discloses a rubber material formula for medicine packaging rubber plugs, relating to the technical field of medical rubber production. The rubber material is prepared from the following raw materials in parts by mass: 70-90 parts of butyl rubber, 10-15 parts of ethylene-vinyl acetate copolymer, 8-12 parts of chitosan, 5-8 parts of hydroxypropyl methylcellulose, 2-5 parts of propolis, 1-5 parts of kaolin, 0.8-3 parts of titanium white, 2-3 parts of nano kieselguhr, 0.5-2 parts of white oil, 0.5-1.5 parts of sorbic acid, 1-4 parts of tri-n-butyl acetyl citrate, 1-3 parts of sodium alginate, 0.5-1 part of stearic acid and 1-2.5 parts of zinc oxide. The formula has the advantages of novel design and accessible raw materials; and the rubber product prepared by the formula has the advantages of higher chemical stability, no irritation, high safety, heat resistance, aging resistance and excellent mechanical properties, and can be prepared into medicine packaging rubber plugs with different sizes.

Description

Technical field: [0001] The invention relates to the technical field of medical rubber production, in particular to a rubber material formula for medicine packaging rubber plugs. Background technique: [0002] With the development of society, there are more and more types of rubber products used in the medical and health field, such as rubber stoppers for various pharmaceutical bottles, pistons for sterile syringes, sealing rubber seals for injections, hoses, catheters, medical air cushions, sterilization Rubber medical gloves, baby pacifiers, blood transfusion tubes, etc. Ideal medical rubber products not only need to have good physical properties, but also must be non-toxic and chemically inert. In particular, rubber products in the body should have the characteristics of not causing disease, not damaging adjacent tissues, not causing allergies, and having good aging properties. [0003] Under the conditions of high temperature and high pressure, the vulcanization system ...

Claims

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Application Information

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IPC IPC(8): C08L23/22C08L23/08C08L5/08C08L1/28C08K13/02C08K3/34C08K3/22C08K5/01C08K5/092C08K5/11C08K5/09
CPCC08K2003/2241C08L23/22C08K2201/011C08L2201/08C08L2205/02C08L2205/035C08L23/0853C08L5/08C08L1/28C08L5/04C08K13/02C08K3/346C08K5/11C08K5/09C08K2003/2296
Inventor 张艳
Owner ANHUI ZHONGMA RUBBER & PLASTIC PROD
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