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Quality detection method for weinai'an tablet

A quality detection method and detection method technology, applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the problems of incomplete quality detection and backward quality detection standards

Active Publication Date: 2014-11-26
GUANGZHOU BAIYUNSHAN ZHONGYI PHARMA COMPANY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The quality inspection standard of Yuanwei'an Capsules is relatively backward. Only the quality inspection of some active substances of Panax notoginseng, artificial bezoar and astragalus is carried out, and the quality cannot be comprehensively detected; the invention provides a high-efficiency , accurate identification and content determination methods

Method used

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  • Quality detection method for weinai'an tablet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Example 1 Thin-layer identification of Astragalus in Weinaian tablets

[0049] A detection method for Weinaian tablets, the detection method adopts a thin-layer chromatography identification method to determine astragalus, comprising the following steps:

[0050] a Prepare the test solution: grind the finished product of Wei Naian tablets, take 2 g, add 50 ml of methanol, sonicate, filter, evaporate the filtrate, add 20 ml of water to the residue to dissolve, then extract 3 times with ethyl acetate, 30 ml each time , Combine the obtained upper ethyl acetate solution, evaporate the ethyl acetate solution, and add 1ml methanol to the residue to dissolve it as the test solution;

[0051] b Prepare astragalus reference medicinal solution: take 2g of astragalus reference medicinal material, add 50ml methanol, sonicate, filter, evaporate the filtrate, add 20ml of water to the residue to dissolve, and then extract 3 times with ethyl acetate, 30ml each time, and combine the upper acet...

Embodiment 2

[0054] Example 2 Simultaneous TLC identification of Astragalus, Red Ginseng and Panax notoginseng in Weinaian tablets

[0055] A detection method for Weinaian tablets. The detection method adopts a thin-layer chromatography identification method to simultaneously determine astragalus, red ginseng and Panax notoginseng in Weinaian tablets, comprising the following steps:

[0056] a Prepare the test solution: grind the finished product of Wei Naian tablets, take 2 g, add 50 ml of methanol, sonicate, filter, evaporate the filtrate, add 20 ml of water to the residue to dissolve, then extract 3 times with ethyl acetate, 30 ml each time , Combine the lower aqueous solution, shake and extract with water saturated n-butanol 3 times, 30ml each time, combine the n-butanol solution, wash 2 times with ammonia test solution, 30ml each time, discard the ammonia solution, and distill the n-butanol solution Dry, add 0.5ml methanol to the residue to dissolve it as the test solution;

[0057] b Prepa...

Embodiment 3

[0060] Example 3 Identification of Artificial Bezoar in Weinaian Tablets by Thin Layer Chromatography

[0061] A detection method for Weinaian tablets. The detection method adopts a thin-layer chromatography identification method to determine artificial bezoar, which comprises the following steps:

[0062] a Prepare the test solution: Grind the finished product of Wei Naian'an tablets, take 0.2 g, add 20 ml of methanol, sonicate, filter, evaporate the filtrate, and add 1 ml of methanol to the residue to dissolve it as the test solution;

[0063] b Preparation of control medicinal material solution: take 10 mg of artificial bezoar control medicinal material, add 2 ml of methanol, ultrasonicate, centrifuge, and take the supernatant as the control medicinal material solution;

[0064] c Prepare the reference substance solution: take the bile acid reference substance and the hyodeoxycholic acid reference substance, and add methanol to make a solution containing 1 mg of the above reference ...

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Abstract

The invention discloses a quality detection method for a weinai'an tablet. The quality detection method adopts one or more of the following identification and content determination items: thin-layer identification of radix astragali; thin-layer identification of radix astragali, red ginseng and pseudo-ginseng; thin-layer identification of atificial cow-bezoar; high performance liquid chromatography qualitative and quantitative identification method of weinai'an tablet; and high performance liquid chromatography quantitative identification method of Astragaloside IV. The method provided by the invention improves and revises the original weinai'an capsule quality standards, revises and enlarges thin-layer identification of radix astragali's four flavonoid components and Astragaloside IV, simultaneously revises and enlarges thin-layer identification of red ginseng, and identifies the index components Astragaloside IV, ginsenoside Rg1, Rb1 and notoginsenoside R1 at the same time. The method employs an HPLC-PDA-ELSD combined technology to establish a main active ingredient content determination and characteristic spectrum to realize effective control of the weinai'an tablet quality. At the same time, the method has the advantages of high efficiency, accurate quantification, good stability, high precision and excellent repeatability.

Description

Technical field [0001] The invention relates to a quality detection method of Weinaian tablets. Background technique [0002] Weinaian capsules are mainly composed of astragalus, panax notoginseng, red ginseng, nacre powder, artificial bezoar, etc. It has the functions of invigorating qi and spleen, promoting blood circulation and relieving pain. It is used for stomach pain caused by spleen and stomach qi deficiency and congestion. Abdominal pain or tingling, poor appetite; chronic gastritis, gastric and duodenal ulcers with the above symptoms, the quality standard is now included in the 2010 edition of the Chinese Pharmacopoeia, Chinese patent number ZL200510037077.7, invention The invention patent entitled "A Chinese patent medicine for treating peptic ulcer and its preparation method" discloses its composition and its preparation method. On the basis of keeping the original formula of Wei Nai'an capsule unchanged, guided by the theory of Chinese medicine, based on clinical cu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/90G01N30/88
Inventor 陈蔚文严萍詹若挺苏碧茹梁小银林文华张敏林传权邓慧敏赖晓明刘文惠谢洁娜
Owner GUANGZHOU BAIYUNSHAN ZHONGYI PHARMA COMPANY
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