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Improved dosage form containing extract from bark of liriodendron tulipifera as active ingredient

The technology of Liriodendron tulipifera and its extract is applied in the field of pharmaceutical preparations for the treatment of gastrointestinal diseases, can solve the problems of insolubility, low bioavailability, low solubility and dissolution rate, and achieves easy dissolution, prevention or treatment of gastrointestinal diseases. tract disease, the effect of increased bioavailability

Inactive Publication Date: 2014-11-12
CHO DANG PHARM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0014] On the other hand, the bark extract of Liriodendron tulipifera has the following disadvantages: due to its poor solubility in the body, when administered in vivo, during the absorption process, due to its low solubility and dissolution rate in the digestive juice, it makes it have low bioavailability

Method used

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  • Improved dosage form containing extract from bark of liriodendron tulipifera as active ingredient
  • Improved dosage form containing extract from bark of liriodendron tulipifera as active ingredient
  • Improved dosage form containing extract from bark of liriodendron tulipifera as active ingredient

Examples

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preparation example 1

[0050] Preparation Example 1: Preparation of Isolated and Purified Liriodendron bark extract

[0051] 200 g of chopped and dried bark of Liriodendron tulipifera was extracted with 800 ml of ethyl acetate for 24 hours at 50°C. The obtained extract solution was concentrated and dried under reduced pressure. 6.83 g of extract was finally obtained. The amount of epituliprolactone was 3.96 wt%, and the amount of lignolide was 0.18 wt%.

[0052] Dissolve 1 g of the extract obtained in the above steps with 50 ml of 70% ethanol. After adding 50 ml of hexane, the mixture was stirred and partitioned. The resulting 70% ethanol fraction was separated and dried. Finally, 0.483 g of purified extract was obtained. The amount of epituliprolactone was 9.72 wt%, and the amount of lignolide was 0.28 wt%.

preparation example 2

[0053] Preparation Example 2: Preparation of Isolated and Purified Liriodendron bark extract

[0054] 200 g of chopped and dried bark of Liriodendron tulipifera was extracted with 800 ml of ethyl acetate for 48 hours at 50°C. The obtained extract solution was concentrated and dried under reduced pressure. 7.67 g of extract was finally obtained. The amount of epituliprolactone was 3.94 wt%, and the amount of lignolide was 0.14 wt%.

[0055] Dissolve 1 g of the extract obtained in the above steps with 50 ml of 70% ethanol. After adding 50 ml of hexane, the mixture was stirred and partitioned. The resulting 70% ethanol fraction was separated and dried. Finally, 0.571 g of purified extract was obtained. The amount of epituliprolactone was 10.94 wt%, and the amount of lignolide was 0.30 wt%.

preparation example 3

[0056] Preparation Example 3: Preparation of Isolated and Purified Liriodendron bark extract

[0057] 200 g of chopped and dried bark of Liriodendron tulipifera was extracted with 800 ml of dichloromethane for 72 hours at 36°C. The obtained extract solution was concentrated and dried under reduced pressure. 4.95 g of extract was finally obtained. The amount of epituliprolactone was 5.10 wt%, and the amount of lignolide was 0.35 wt%.

[0058] Dissolve 1 g of the extract obtained in the above steps with 50 ml of 70% ethanol. After adding 50 ml of hexane, the mixture was stirred and partitioned. After the ethanol fraction was obtained, 40 ml of water and 90 ml of dichloromethane were added and stirred. The resulting dichloromethane fraction was separated and dried. Finally, 0.071 g of purified extract was obtained. The amount of epituliprolactone was 23.43 wt%, and the amount of lignolide was 0.79 wt%.

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Abstract

The present invention relates to an improved dosage form containing, as active ingredients, epitulipinolide and costunolide extracted from the bark of Liriodendron tulipifera and, more specifically, to a dosage form for treating the gastrointestinal tract, the dosage form containing, as active ingredients, epitulipinolide and costunolide, which are the active ingredients of the extract from the bark of Liriodendron tulipifera.

Description

technical field [0001] The present invention relates to a pharmaceutical preparation containing epitulipinolide and costunolide extracted from the bark of Liriodendron tulipifera as active ingredients. In particular, the present invention relates to a pharmaceutical preparation for treating gastrointestinal diseases, which contains, as active ingredients, epiliriolide and corylidene extracted from the bark of Liriodendron tulipifera. Background technique [0002] It is reported that gastritis and / or gastric ulcer is the most common disease because about 10% of Koreans suffer from gastritis and / or gastric ulcer more than once in their lifetime. Gastritis and / or gastric ulcers are known to be caused by gastric acid digestion of the stomach wall comprising the mucosa, submucosa, muscularis externa and serosa. If only the gastric mucosa is damaged, it is called gastritis, while if the gastric submucosa and outer muscular layer are damaged, it is called gastric ulcer. In additi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/127A61K36/896A61P1/04A61P1/00
CPCA61K9/127A61K36/57A61K9/0056A61K9/0095A61K9/2027A61K9/4858A61K31/343A61P1/00A61P1/04A61K36/896
Inventor 金落斗
Owner CHO DANG PHARM
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