Injection-grade echinacea extractive and injection thereof

Abstract

The invention relates to an injection-grade echinacea extractive and an injection thereof. The extractive is prepared according to the following method: 1) crushing echinacea for usage; 2) warmly dipping the crushed echinacea powder with an aqueous solution containing a base to extract for two times, filtering, discarding medicine residues, and merging the filtrate for usage; 3) applying the filtrate obtained in the step 2) to anion resin, washing with water, then eluting with an ethanol solution containing an acid, collecting the eluate, and recovering ethanol in a reduced-pressure manner, and obtaining a concentrate for usage; and 4) performing salting out on the concentrate obtained in the step 3), refrigerating, filtering, discarding filtrate, and washing the precipitate with water, so as to obtain the extractive. The provided injection is high in content of intermediates chicoric acid and caftaric acid, low in cost and good in medicine effect.

Description

technical field [0001] The invention relates to a traditional Chinese medicine extract, in particular to an injection-grade echinacea purpurea extract and a preparation thereof. Background technique [0002] Echinacea (Echinacea) is a perennial herb of the genus Echinacea in the Compositae family (Compositea). It is native to the central and western regions of North America. Immunity" herbal medicine has outstanding anti-infection and immune-stimulating effects. [0003] Echinacea is a traditional medicinal material of North American Indians. It was very popular in European and American countries in the 20th century. After 1920, with the rapid development of modern western medicine and the discovery of penicillin, its medicinal use almost disappeared. In recent years, with the development of alternative medicine therapy, Echinacea has become popular again and is currently widely used in medicines, nutritional supplements and health foods in Europe and America. [0004] The...

AI Technical Summary

Problems solved by technology

It has the following disadvantages: ①The extract is directly subjected to microfiltration treatment, which may easily cause clogging of the microfiltration membrane, and the production efficiency is low, so it is not suitable for large-scale production

This method has the following deficiencies: ① The preparation process takes fresh Echinacea purpurea as the research object. Although the content of cichoric acid in fresh Echinacea purpurea is relatively high, the production of Echinacea purpurea extract is limited by seasons, and the source of medicine of Echinacea purpurea extract limits its industrialization Production

②The production process is mainly based on the content of cichoric acid, and the polysaccharide components that play an immune role in the medicinal materials are not considered, resulting in a waste of medicinal material resources to a certain extent

③In the preparation process, the medicinal materials are extracted twice with high-concentration ethanol, and a large amount of ethanol is adsorbed in the dregs of the medicine, but no treatment has been seen, and the cost of the Echinacea purpurea extract produced by it is relatively high

[0012] CN200610061847.6 (publication number is CN101032541A) discloses a kind of Echinacea purpurea extract and its preparation method and content determination method, and this method has the following deficiencies: 1. The amount of ethanol used for extraction is large, the ethanol consumption is large, and the cost is high

According to experimental research, the transfer rate of chicory acid in the process is low, about 40-50%

②The content of cichoric acid in the Echinacea purpurea extract prepared by its process is low, and the index is single, which does not reflect the content transfer of total polyphenols and total polysaccharides

This method has the following disadvantages: it adopts macroporous resin for purification, and the selective adsorption of polyphenols is poorer than that of anion resin, and the cost is higher than that of anion resin

[0015] CN201110057558.X (publication number is CN102161620A) discloses a method for the non-column chromatography separation and purification of cichoric acid from the extract of Echinacea purpurea, which has the following disadvantages: the invention directly uses the extract of Echinacea purpurea as raw material, in addition, in Chloroform extraction is used in the extraction process, and the extraction solvent is highly toxic, which is not conducive to labor protection

This method has the following deficiencies: 1. liquid ultrafiltration, easy to block, low efficiency, not suitable for large-scale production; 2. supercritical extraction, high cost; 3. final cationic resin column purification, cichoric acid is not easy to adsorb, low yield

It has the following disadvantages: extraction with pH=12 calcium hydroxide ethanol solution is likely to cause calcium ions to chelate with polyphenolic components such as cichoric acid to form precipitated insoluble matter, and it is easy to cause cichoric acid to contain esters in a high-temperature alkaline environment. The breakage of the bond caused the destruction of cichoric acid and other components, and after the inventor verified the extraction process, the content in the final prepared extract was also inconsistent with the content mentioned in the document

[0018] In the preparation process of the existing Echinacea purpurea extract, it is easy to cause more loss of cichoric acid, the content is not high, it is not suitable for industrial production, the production cost is high, and the utilization rate of medicinal materials is not high. In order to solve the above problems, the inventor proposed a A method for preparing echinacea purpurea extract for injection, preparation method and application of injection

Images