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Pharmaceutical composition containing as active ingredient extract from bark of liriodendron tulipifera

The technology of an active ingredient, epitulipriolide, applied in the field of pharmaceutical compositions containing the bark extract of Liriodendron tulipifera as an active ingredient, can solve the problem that the cause of gastritis and/or gastric ulcer has not been clearly disclosed, and the Development of treatment methods, complicated causes, etc.

Inactive Publication Date: 2014-10-29
CHO DANG PHARM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] However, the causes of gastritis and / or gastric ulcer have not been clearly disclosed due to the complex causes of gastritis and / or gastric ulcer
Therefore, no definitive treatment has been developed

Method used

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  • Pharmaceutical composition containing as active ingredient extract from bark of liriodendron tulipifera
  • Pharmaceutical composition containing as active ingredient extract from bark of liriodendron tulipifera
  • Pharmaceutical composition containing as active ingredient extract from bark of liriodendron tulipifera

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Experimental program
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Effect test

preparation example Construction

[0044] The method for preparing the bark extract of Liriodendron tulipifera can be explained as follows.

[0045] The preparation method of the present application comprises 2 preparation steps: (1) a step (method 1) of preparing the bark extract of Liriodendron tulipifera using a specific solvent of ethyl acetate or dichloromethane, (2) by improving step (1) Purification step (method 2) to obtain purified material from the amount of the component indicator in the extract obtained.

[0046] In method 1, after the bark of Liriodendron tulipifera is chopped and powdered, extraction is performed using an extraction solvent selected from ethyl acetate or dichloromethane. After concentrating the extract, the obtained substance contains epituliprolactone and corylidene as active ingredients.

[0047] In Method 2, the extract obtained in Method 1 was dissolved using an aqueous alcohol solution. After adding hexane, lipid components and water-insoluble substances dissolved in hexane...

preparation example 1

[0063] Preparation Example 1: Preparation of Isolated and Purified Liriodendron bark extract

[0064] 200 g of chopped and dried bark of Liriodendron tulipifera was extracted with 800 ml of ethyl acetate for 24 hours at 50°C. The resulting extraction mixture was concentrated and dried under reduced pressure. 6.83 g of extract was finally obtained. The amount of epituliprolactone was 3.96 wt%, and the amount of lignolide was 0.18 wt%.

[0065] Dissolve 1 g of the extract obtained in the above steps with 50 ml of 70% ethanol. After adding 50 ml of hexane, the mixture was stirred and partitioned. The resulting 70% ethanol fraction was separated and dried. Finally, 0.483 g of purified extract was obtained. The amount of epituliprolactone was 9.72 wt%, and the amount of lignolide was 0.28 wt%.

[0066] figure 1 LC-MS chromatographic data of the extract isolated from the bark of Liriodendron tulipifera described in Preparation 1 are shown. It was confirmed that the extract o...

preparation example 2

[0067] Preparation Example 2: Preparation of Isolated and Purified Liriodendron bark extract

[0068]200 g of chopped and dried bark of Liriodendron tulipifera was extracted with 800 ml of ethyl acetate for 48 hours at 50°C. The resulting extraction mixture was concentrated and dried under reduced pressure. 7.67 g of extract was finally obtained. The amount of epituliprolactone was 3.94 wt%, and the amount of lignolide was 0.14 wt%.

[0069] Dissolve 1 g of the extract obtained in the above steps with 50 ml of 70% ethanol. After adding 50 ml of hexane, the mixture was stirred and partitioned. The resulting 70% ethanol fraction was separated and dried. Finally, 0.571 g of purified extract was obtained. The amount of epituliprolactone was 10.94 wt%, and the amount of lignolide was 0.30 wt%.

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Abstract

The present invention relates to a pharmaceutical composition containing, as active ingredients, epitulipinolide and costunolide extracted from the bark of Liriodendron tulipifera. More specifically, the present invention relates to a pharmaceutical composition for treating the gastrointestinal tract, the composition containing, as active ingredients, epitulipinolide and costunolide, which are the active ingredients of the extract from the bark of Liriodendron tulipifera, and to the use thereof as a therapeutic agent for gastrointestinal diseases.

Description

technical field [0001] The present invention relates to a pharmaceutical composition containing epitulipinolide and costunolide extracted from the bark of Liriodendron tulipifera as active ingredients. In particular, the present invention relates to a pharmaceutical composition and / or therapeutic agent for treating gastrointestinal diseases, the pharmaceutical composition and / or therapeutic agent containing Liriodendron tulipifera extracted from the bark of Liriodendron tulipifera Esters and corylidene as active ingredients. Background technique [0002] It is reported that gastritis and / or gastric ulcer is the most common disease because about 10% of Koreans suffer from gastritis and / or gastric ulcer more than once in their lifetime. Gastritis and / or gastric ulcers are known to be caused by gastric acid digestion of the stomach wall comprising the mucosa, submucosa, muscularis externa and serosa. If only the gastric mucosa is damaged, it is called gastritis, while if the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/896A61P1/04A61P1/00
CPCA61K36/57A61K2236/00A61K31/365A61P1/00A61P1/04A61K36/896
Inventor 金落斗
Owner CHO DANG PHARM
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