Method for preparation of flomoxef in vertical logistics system

Abstract

The invention relates to the pharmaceutical field, especially to production of bulk drugs by a solvent crystallization method, and also relates to an aseptic logistics method. The method for preparation of flomoxef in a vertical logistics system includes: adding a crystallization solvent into a flomoxef reaction solution, performing crystal growing, then conducting solid-liquid separation, and transferring the separated solid by gravity. The crystallization solvent is mixed solution of acetone and dichloromethane. With the method provided by the invention, the pollution problem caused by environmental exposure in a material transfer process is avoided, and the prepared bulk drug has a high aseptic level. In addition, the logistics system with gravity as the main driving force has the characteristics of high transport efficiency and low cost.

Description

Technical field [0001] The present invention relates to the field of pharmacy, in particular to the production of bulk drugs by solvent crystallization method, and also to aseptic logistics method. Background technique [0002] Fluoxef is the third-generation cephalosporin for injection. It is characterized by strong activity against methicillin-sensitive Staphylococcus aureus and methicillin-resistant Staphylococcus aureus, and is against other gram-positive bacteria and gram-negative bacteria. The bacteria also have good broad-spectrum activity. It has high stability to β-lactamase. In the solvent crystallization method, the production of aseptic fluoxefone raw materials usually involves the processes of dissolution, aseptic filtration, crystallization, solid-liquid separation, drying, crushing, and packaging. The traditional method uses plane operation. Because the material obtained through the solid-liquid separation process is powder, it will inevitably be exposed to the a...

AI Technical Summary

Problems solved by technology

The traditional method adopts plane operation. Since the material obtained in the process of solid-liquid separation is powder, it will inevitably be exposed to the air during the transfer process. Although 100-level laminar flow protection is used during the exposure process, due to the Manual operation is still required for remaining. In fact, exposed materials cannot be transferred in a dynamic A-level clean environment, and the level of sterility assurance is low.

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