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Anti-inflammatory and analgesic medicine composition and application thereof

An anti-inflammatory and analgesic composition technology, which is applied in the field of anti-inflammatory and analgesic pharmaceutical compositions, can solve the problems that the pain treatment drug market does not meet the clinical needs, etc., achieve obvious analgesic effect, significant analgesic effect, reduce twist The effect of body count

Active Publication Date: 2014-10-29
上海金不换兰考制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the total sales of the global analgesic drug market is estimated to be between 40 billion and 45 billion US dollars, and the pain treatment drug market still obviously does not meet the clinical needs

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] The preparation of embodiment 1 Chinese medicine oral liquid

[0016] Weigh 3.0kg of Sijiqing and 8.0kg of orange leaves, wash and remove impurities, dry and crush; then add water to the above granular medicinal materials to cover the medicinal surface 2cm, soak for 1h, remove the medicinal materials, put them in a multi-functional extraction tank, add water and decoct Extract twice, add 16 times the amount of water for the first time, decoct for 2 hours, take the decoction, filter, add 16 times the amount of water for the second time, decoct for 1 hour, take the two decoctions and combine, Filtrate, heat and concentrate until 1ml of the solution is equivalent to 4g of crude drug, store in a refrigerator at 5°C for 24 hours, and filter the refrigerated solution to obtain the medicinal solution.

[0017]

Embodiment 2

[0018] The preparation of embodiment 2 Chinese medicine oral liquid

[0019] Weigh 4.0kg of Sijiqing and 7.0kg of tangerine leaves, wash and remove impurities, dry, and crush; then add water to the above granular medicinal materials to cover the medicinal surface 2cm, soak for 1h, remove the medicinal materials, put them in a multi-functional extraction tank, add water and decoct For the second time, add 20 times the amount of water of the medicinal materials for the first time, decoct for 2 hours, take the decoction, filter, add 20 times the amount of water of the medicinal materials for the second time, decoct for 1 hour, take the two decoctions and combine, filter After heating and concentrating until each 1ml of solution is equivalent to 4g of crude drug, put it in a refrigerator at 5°C for 24 hours at low temperature, and filter the refrigerated solution to obtain the medicinal solution.

[0020]

Embodiment 3

[0021] Example 3 Analgesic test of traditional Chinese medicine on acetic acid-induced writhing reaction in mice

[0022] Thirty Kunming mice, weighing 18-22 g, were half male and half male. The dosage of each mouse was determined according to body weight, and all mice were randomly divided into a low-dose Chinese medicine group (10ml / kg), a high-dose Chinese medicine group (20ml / kg), and a blank control group (normal saline 0.2ml / 10g). The medicinal solution prepared in Example 1 was administered continuously by intragastric administration for 3 days, once a day. 1 hour after the last administration, each mouse was injected intraperitoneally with 0.6% acetic acid solution 0.2ml / 10g (the acetic acid solution was prepared before use), and the writhing reactions (abdominal contraction, indentation, stretching) occurred within 15 minutes after the injection of the acetic acid solution were observed and recorded. The number of writhing times of each rat (hind limb, hip raising,...

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PUM

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Abstract

The invention discloses an anti-inflammatory and analgesic medicine composition and an application thereof. The medicine composition is prepared from the following traditional Chinese medicinal materials in parts by weight: 20-40 parts of purpleflower holly leaves and 60-100 parts of tangerine leaves. The medicine composition has the significant effects of inflammatory prevention and analgesia and good clinical significance, and is free of immunosuppression and low in toxic and side effects.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to an anti-inflammatory and analgesic pharmaceutical composition and its application. Background technique [0002] Inflammation is a common and frequently-occurring disease. It is a defensive response of living tissues with vascular system to injury factors. an important protective response. Trauma infections on the body surface and most common and frequently-occurring diseases of various organs (such as boils, carbuncles, pneumonia, hepatitis, nephritis, etc.) are all inflammatory diseases. Pain is a pathophysiological process accompanied by emotional responses when the body receives noxious stimuli from the internal and external environment. A symptom of a disease. [0003] Anti-inflammatory and analgesic drugs are a class of commonly used drugs with anti-inflammatory, antipyretic, analgesic and anti-rheumatic effects. Anti-inflammatory and analgesic drugs are the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/752A61K36/80A61P29/00
Inventor 李健
Owner 上海金不换兰考制药有限公司
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