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Application of farnesoid X receptor stimulant GW4064 in preparation of medicine for treating non-alcoholic fatty liver disease (NAFLD) caused by senescence

A receptor agonist, non-alcoholic technology, applied in the field of biomedicine, can solve problems such as unclear molecular mechanism

Inactive Publication Date: 2014-10-29
RUIJIN HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, current studies only suggest that there is a correlation between age and liver triglyceride content, and the underlying molecular mechanism is still unclear

Method used

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  • Application of farnesoid X receptor stimulant GW4064 in preparation of medicine for treating non-alcoholic fatty liver disease (NAFLD) caused by senescence
  • Application of farnesoid X receptor stimulant GW4064 in preparation of medicine for treating non-alcoholic fatty liver disease (NAFLD) caused by senescence
  • Application of farnesoid X receptor stimulant GW4064 in preparation of medicine for treating non-alcoholic fatty liver disease (NAFLD) caused by senescence

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] 1. Increased precipitation of triglycerides in the liver of mice in the aging group

[0021] In order to clarify the role of aging in the occurrence and development of NAFLD, we selected C57BL / 6 mice of various ages as the research objects (2 months old, marked as 2m, Young; 8 months old, marked 8m, Middle; 18 months old , marked as 18m, Old). Obesity is known to be an independent risk factor for NAFLD, so male mice with similar body weights were selected for experiments. There was no significant difference in body weight among the three groups of mice. We detected the glucose and lipid metabolism in the whole body of the mice. There was no significant difference in the levels of fasting blood glucose and plasma cholesterol among the three groups of mice, but the plasma triglyceride level of the 18-month-old mice was significantly higher than that of the other two groups.

[0022] Further, we compared the liver triglyceride metabolism in the three groups of mice. Fir...

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Abstract

The invention belongs to the field of biological medicines and in particular relates to application of a farnesoid X receptor stimulant GW4064 in preparation of medicine for treating non-alcoholic fatty liver disease caused by senescence. A naturally senile C57BL / 6 mouse serves as a research object, triglyceride in the liver of the mouse is deposited with the increase of age, the mouse suffers from hypertriglyceridemia, and the change is independent from the influence of weight factors. The farnesoid X receptor expression is reduced in the liver of the senile mouse, the deposition of the triglyceride in the liver of the senile mouse can be inhibited by the farnesoid X receptor stimulant GW4064, the NAFLD disease caused by natural aging is treated, and a theoretical basis and experimental data can be provided for clinically treating the NAFLD disease.

Description

technical field [0001] The invention belongs to the field of biomedicine, and particularly relates to the application of farnesoid X receptor agonist GW4064 in the preparation of non-alcoholic fatty liver disease medicine caused by aging. Background technique [0002] Non-alcoholic fatty liver disease (NAFLD) is a liver lesion characterized by the accumulation of triglycerides in hepatocytes. The patient has no history of excessive drinking, and other liver damage caused by viral infection, drugs or autoimmunity is excluded. In recent years, with the rapid economic development and changes in people's lifestyles, the incidence of NAFLD has increased rapidly around the world. At present, the incidence of NAFLD has reached 30% in western developed countries, becoming the primary cause of chronic liver disease. In my country, the incidence of NAFLD has also increased year by year in recent years, and it is the second largest liver disease after viral hepatitis. According to epi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/42A61P1/16
Inventor 宁光熊雪莲李小英陆炎王卫庆
Owner RUIJIN HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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