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Artificial skin and preparation method thereof

A technology of artificial skin and dermis, applied in the field of bionic materials, can solve the problems of poor permeability of dermal stent, poor anti-infection effect, poor anti-scar effect, etc. Effect

Active Publication Date: 2014-10-01
SHENZHEN QIKANG MEDICAL DEVICES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The current artificial dermal scaffold simulates the three-dimensional network structure of collagen fibers. Studies have found that although the dense scaffold has good anti-scar effect, it will restrict fibroblasts from quickly reaching the wound site, resulting in poor permeability of the dermal scaffold, slow vascularization rate, and anti-scarring effect. The effect of infection is not good; the loose scaffold is conducive to the rapid growth of blood vessels and fibroblasts, but the anti-scar effect is poor in the later stage
[0007] In addition, the disadvantages of existing artificial skin are: it is difficult to achieve reliable fixation when applied to wounds (especially for irregular or concave body parts, or children), and it is easy to cause infection or blood clots under the artificial skin after implantation Whether it can overcome this shortcoming will have an important impact on the success of product implantation

Method used

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preparation example Construction

[0030] A method for preparing artificial skin, comprising the following steps: importing the double-layer structure model of the dermis into a three-dimensional printer; dissolving type I collagen with acetic acid solution, adding glutaraldehyde and growth factor-loaded microspheres, mixing evenly, Vacuum degassing to obtain printing materials; put the printing materials in the ink cartridge of the 3D printing equipment, and perform 3D printing to obtain the dermis layer, which is the artificial skin.

[0031] Preferably, the concentration of the acetic acid solution is 0.10-0.50 mol / L.

[0032] Preferably, the concentration of type I collagen in the printing material is 1-20 wt%, the concentration of glutaraldehyde is 0.10-0.50 wt%, and the concentration of microspheres is 0.01-0.2 wt%.

[0033] Preferably, two nozzles are used to print the upper and lower layers of the dermis respectively, the diameter of the nozzle for printing the lower layer is 100-200 μm, the diameter of...

Embodiment 1

[0038] An artificial skin, including epidermis and dermis; wherein, the epidermis is densely covered with micropores with a pore size of 100 μm, the hole spacing is 1 mm, and the thickness of the epidermis is 0.2 mm; the dermis is a double-layer structure made of collagen bundles , wherein, the upper layer is combined with the epidermis and is a microgroove structure arranged in parallel with a thickness of 10 μm, the distance between adjacent microgrooves is 10 μm, and the diameter of collagen bundles is 10 μm. The lower layer is in contact with the wound surface and is a three-dimensional network structure with a thickness of 2mm, the pore size of the three-dimensional network structure is 100μm, and the diameter of the collagen bundle is 150μm. The collagen bundles comprise type I collagen and growth factor loaded microspheres.

[0039] The preparation method of the above-mentioned artificial skin is as follows:

[0040] (1) Import the above-mentioned double-layer structur...

Embodiment 2

[0046] An artificial skin, including epidermis and dermis; wherein, the epidermis is densely covered with micropores with a pore size of 300 μm, the hole spacing is 2 mm, and the thickness of the epidermis is 0.2 mm; the dermis is a double-layer structure made of collagen bundles , where the upper layer is combined with the epidermis and is a microgroove structure arranged in parallel with a thickness of 100 μm, the distance between adjacent microgrooves is 100 μm, and the diameter of collagen bundles is 100 μm. The lower layer is in contact with the wound surface and is a three-dimensional network structure with a thickness of 3.5mm, the pore size of the three-dimensional network structure is 150μm, and the diameter of the collagen bundle is 100μm. The collagen bundles comprise type I collagen and growth factor loaded microspheres.

[0047] The preparation method of the above-mentioned artificial skin is as follows:

[0048] (1) Import the above-mentioned double-layer struct...

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Abstract

The invention discloses an artificial skin and a preparation method thereof. The artificial skin is controllable in structure, and comprises an epidermal layer and a double layer corium layer, wherein the upper layer of the double layer corium layer is formed by arranging microgroove structures in parallel mode, and the lower layer of the double layer corium layer is of three dimensional network structure. The artificial skin has obvious advantages in fibroblast migration speed, degradation speed and cicatrix resisting effects. A dermis support is prepared from the artificial skin after the artificial skin is processed through a three dimensional printing method, and therefore the dermis support is accurate in structure control, simple in preparation technology, low in rejection rate and obvious in economic benefit.

Description

Technical field [0001] The present invention is a technology field in bionic materials, which involves a method of artificial skin and its preparation. Background technique [0002] As the largest organ of the human body, the skin plays a role in protecting, perceiving and regulating.When skin defects are caused by factors such as external injuries or diseases, the harm can be extremely mild or fatal. [0003] Since the early 1990s, foreign skin repair technology began to use artificial synthesis of leather bracket as its mainstream. There have been widely used products, such as Integra, Dermagraft, Pinsk, etc., which have good clinical effects, but in the long -term effects such as suppressionThere are still many challenges in scar hyperplasia, skin appearance and functional recovery and reconstruction. [0004] The natural leather matrix is mainly composed of collagen fibers and elastic fibers. The two are intertwined with each other. The thickness of the leather tissue is clos...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/10A61L27/24A61L27/18A61L27/54A61L27/60
Inventor 谭荣伟许孟强
Owner SHENZHEN QIKANG MEDICAL DEVICES
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