Lixivaptan crystal form I and preparation method and use thereof
A technology of tanned crystal form and crystal form, applied in the field of anti-heart failure drugs, can solve the problems of high price, low utilization rate and high production cost
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Embodiment 1
[0047] Weigh 20.0g of lixiptan, add 80mL of methanol, heat to 60°C and stir for 1 hour, naturally cool to room temperature, a solid precipitates, filter, and vacuum dry for about 24 hours to obtain white crystals of lixiptan (form I) .
Embodiment 2
[0049] Weigh 20.0g of lixiptan, add 40mL of methanol, heat to 60°C and stir for 2 hours, naturally cool to room temperature, a solid precipitates, filter, and vacuum dry for about 24 hours to obtain white crystals of lixiptan (form I) .
Embodiment 3
[0051] Weigh 20.0g of lixiptan, add 120mL of methanol, heat to 60°C and stir for 3 hours, naturally cool to room temperature, a solid precipitates, filter, and vacuum dry for about 24 hours to obtain white crystals of lixiptan (form I) .
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