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Application of compound donkey-hide gelatin pulp in preparation of medicament for menstrual period health care

A technology for compound donkey-hide gelatin and medicine, which can be used in drug combinations, pharmaceutical formulations, plant raw materials, etc., and can solve problems such as the lack of pharmacological effects of compound donkey-hide gelatin

Inactive Publication Date: 2014-09-24
SHAN DONG DONG E E JIAO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] And so far, there is no report on the pharmacological effects of compound donkey-hide gelatin in menstrual health care.

Method used

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  • Application of compound donkey-hide gelatin pulp in preparation of medicament for menstrual period health care
  • Application of compound donkey-hide gelatin pulp in preparation of medicament for menstrual period health care
  • Application of compound donkey-hide gelatin pulp in preparation of medicament for menstrual period health care

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Example 1 to the effect of enriching blood on mice with blood deficiency caused by blood loss

[0035] The preparation of compound donkey-hide gelatin syrup administration solution: take 120mL of compound donkey-hide gelatin pulp and concentrate it into 20mL as high dose; take 120mL of compound donkey-hide gelatin pulp and concentrate it into 40mL as low dose.

[0036] Take 40 mice of 18-20 g, and divide them into 4 groups randomly, 10 mice in each group, which are blank control group (normal saline group), low-dose group (compound donkey-hide gelatin small-dose group), high-dose group (compound donkey-hide gelatin large-dose group). dose group). About 0.5mL of blood is taken from the orbit of each mouse to create a model of hemorrhagic anemia in mice, and Hb and RBC (ie, hemoglobin and red blood cell count) are measured at the same time. Low-dose group and high-dose group were given intragastric administration of 0.2mL / 10g, and the negative control group was given equ...

Embodiment 2

[0041] Example 2 Effect of compound donkey-hide gelatin paste on myoelectric activity of rabbit uterine smooth muscle in vivo

[0042] Take 40 healthy adult female rabbits, weighing 2.40±0.1kg, and randomly divide them into 4 groups, namely: negative control group (normal saline), positive control group (Municus granule group, dose: 1.25g / kg / time), large Dosage group (compound donkey-hide gelatin high-dose group, dose: 1.75g / kg / time), low-dose group (compound donkey-hide gelatin small-dose group, dose: 1.25g / kg / time), intragastric administration, daily administration Once, for 3 consecutive days. Before the experiment, the rabbits were fasted for 12 hours, and 1 hour after the last drug administration, they were anesthetized by intravenous injection of 3% pentobarbital during the experiment, and the laparotomy was performed to find out one side of the uterine horn, and the surrounding tissues were peeled off, and used in the body The extracellular recording method of smooth m...

Embodiment 3

[0046] Example 3 Effect of Compound Ejiao Syrup on Dysmenorrhea-like Reactions in Rats Induced by Oxytocin

[0047] Take 40 healthy adult female rats, weighing 210g±8g, and randomly divide them into 4 groups, which are negative control group (normal saline group), positive control group (Murusa granule group, dose: 0.75g / kg / time), high-dose group (compound donkey-hide gelatin high-dose group, dose: 1.35g / kg / time), low-dose group (compound donkey-hide gelatin small-dose group, dose: 0.85g / kg / time), intragastric administration once a day, consecutive 4 sky. After the third administration, the rats were subcutaneously injected with diethylstilbestrol (0.1mg / 100g body weight), fasted for 12h, and 1h after the last administration, they were respectively intraperitoneally injected with 0.1u / kg of oxytocin and observed for 30 minutes. Hypercontraction of the uterus, the latency period for dysmenorrhea-like reactions (that is, the interval between the administration of drugs and the ...

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Abstract

The invention relates to an application of compound donkey-hide gelatin pulp in preparation of medicaments for menstrual period health care, and a pharmaceutical composition for menstrual period health care, wherein the pharmaceutical composition comprises an effective amount of compound donkey-hide gelatin pulp with respect to health care, and pharmaceutically acceptable carriers. A large number of experiments find that compound donkey-hide gelatin pulp has obvious blood-enriching effect on mice with blood deficiency due to blood loss, has certain inhibition effect on contraction of rabbit uterine smooth muscle, has obvious inhibition effect on rabbit in-vivo uterine smooth muscle spasm caused by pitocin, can alleviate excess contraction of rabbit uterine smooth muscle, has obvious alleviation effect on rat dysmenorrhea response caused by pitocin, can prolong the response latency, can significantly prolong the latency of rat dysmenorrhea spasm caused by pitocin, can reduce the frequency of body torsion, has significant analgesic effect, can obviously reduce rat blood viscosity, has certain blood circulation invigorating effect, and can relieve blood property change such as viscous, thick, coagulated blood of blood-stasis model rats.

Description

technical field [0001] The invention relates to a new application of compound donkey-hide gelatin pulp, in particular to the application of compound donkey-hide gelatin pulp in the preparation of medicines for menstrual health care, and belongs to the field of traditional Chinese medicines. Background technique [0002] Menstruation is a normal physiological phenomenon of women, and normal menstruation is a manifestation of normal development and sound function of female internal genitalia. Women mainly nourish blood, while menstruation consumes a lot of blood. If blood is not nourished, blood deficiency will easily cause symptoms such as sallow complexion, dry hair, dizziness, fatigue, and weakened immunity. After menstruation, it is necessary to nourish yin and blood to make up for the loss of yin blood in the body, reserve enough blood for the body, and make full preparations for the next menstruation. The two major diseases that often occur during women's menstruation a...

Claims

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Application Information

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IPC IPC(8): A61K36/804A61P15/00
Inventor 尤金花周祥山田守生张路张淹史兆松
Owner SHAN DONG DONG E E JIAO
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