A rhodiola wall-breaking preparation

A rhodiola and preparation technology, which is applied in the direction of anti-toxic agents, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problems of easy loss of drug efficacy, easy oxidation of broken wall powder, and stability No high problems, high dissolution rate and stability, good disintegration and stability, simple granulation process

Active Publication Date: 2018-07-13
ZHONGSHAN ZHONGZHI PHARMA GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem to be solved by the present invention is to overcome the defects that the wall-broken powder in the prior art is easy to be oxidized, has low stability, and is easy to lose drug efficacy, and provides a rhodiola wall preparation

Method used

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  • A rhodiola wall-breaking preparation
  • A rhodiola wall-breaking preparation
  • A rhodiola wall-breaking preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Take rhodiola net medicinal material, coarsely pulverize it into a coarse powder of about 100 meshes, and superfinely pulverize it into a powder with a particle size of about 33 μm in 90% of the ultrafine powder, add ethanol-water solution (the mass fraction of ethanol is 30 %) Wet process soft material, the ratio of solution to superfine powder is 0.5:1 (by weight), after mixing, pre-installed 10 mesh sieve, select extrusion speed 50r / min, extrusion force 1MPa to make wet Granules, wet granules are transferred to a hot air circulation oven, set the drying temperature to 85°C, and dried for 2.5 hours until dry, and the whole granules are sieved to obtain the rhodiola wall-broken preparation.

[0029]

[0030] Note: The full score is 10.

Embodiment 2

[0032] Take rhodiola net medicinal material, coarsely pulverize it into a coarse powder of about 100 mesh, and ultrafinely pulverize it into a powder with a particle size of about 33 μm in 90% of the ultrafine powder, add ethanol-water solution (the mass fraction of ethanol is 50 %) soft material by wet method, the ratio of solution to superfine powder is 0.7:1 (by weight), after mixing, pre-installed 10 mesh sieve, extrusion speed 70r / min, extrusion force 0.8MPa Wet granules, the wet granules are transferred to a vacuum microwave drying oven, set the drying temperature to 45°C, and dried for 0.75h until dry.

[0033]

[0034] Note: The full score is 10.

Embodiment 3

[0036] Take rhodiola net medicinal material, coarsely pulverize it into a coarse powder of about 100 meshes, and superfinely pulverize it into a powder with a particle size of about 33 μm in 90% of the ultrafine powder, add ethanol-water solution (the mass fraction of ethanol is 70 %) soft material by wet method, the ratio of solution to superfine powder is 0.9:1 (by weight), after mixing, pre-installed 30-mesh sieve, extrusion speed 80r / min, extrusion force 0.3MPa Wet granules, the wet granules are transferred to a hot air circulation oven, set the drying temperature to 85°C, and dried for 2.5 hours until dry.

[0037]

[0038] Note: The full score is 10.

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Abstract

The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a rhodiola wall-breaking preparation. According to the invention, Rhodiola rosea is crushed into wall-breaking powder, further granulated by ethanol-water wet method, extruded at a certain speed, and dried. Utilization rate, and the preparation has strong stability and good disintegration.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and in particular relates to a Rhodiola rosea wall-breaking preparation. Background technique [0002] Ultrafine pulverization technology is a new technology developed rapidly in recent years. Most of the active ingredients in Chinese herbal medicines are distributed in the cells. Conventional decoction pieces can only release part of the active ingredients, and the utilization rate of active ingredients is 10-30%. However, using the wall-breaking crushing technology, such as crushing Chinese herbal medicine pieces to 300 mesh About 86.7% of the cell wall breaking rate will increase the dissolution of the active ingredients in the medicinal materials, greatly enhance its efficacy, and the utilization rate of the active ingredients will be above 90%, so as to reduce the amount of medicinal materials used and protect the medicinal materials resources. The quality increases the efficacy....

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/10A61K36/41A61K9/16A61P37/04A61P39/06A61P9/10A61P3/06A61J3/00
Inventor 成金乐陈勇军梁学良唐琳乔卫林
Owner ZHONGSHAN ZHONGZHI PHARMA GRP
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