Compound pharmaceutical composition of cefoperazone sodium and tazobactam sodium and preparation process thereof
A technology for tazobactam sodium and cefoperazone sodium is applied in the field of compound pharmaceutical compositions containing cefoperazone sodium and tazobactam sodium, which can solve the problems of irrational drug compatibility, endanger the life of patients, affect the health of patients, etc., and overcome the problem of incompatibility. , Good uniformity and excellent stability
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Embodiment 1
[0036] Prescription: 100 bottles
[0037]
[0038] Weigh the prescribed amount of cefoperazone sodium, tazobactam sodium, ambroxol hydrochloride, mannitol, and sodium bisulfite in the aseptic operation room, dissolve them in 360ml of water for injection, wait until they are completely dissolved, and then dissolve them with citric acid-citric acid Adjust the pH value of the mixed solution to 4.8-5.5 with sodium, then add 40ml of water for injection, add activated carbon for needles, stir, let stand for 20min, and decarburize with 0.45μm and 0.22μm filter membranes successively, and distill the sterile solution according to the volume of each bottle. 1ml is divided into 7ml freeze-dried vials, half stoppered, sent to a freeze-drying box, and freeze-dried to obtain the finished product.
[0039] Among them, the freeze-drying process is as follows: rapidly cool the aliquoted sterile solution to -45°C for pre-freezing, so that the sterile solution is completely converted into a ...
Embodiment 2
[0045] Prescription: 1000 bottles
[0046]
[0047]Take cefoperazone sodium, tazobactam sodium, ambroxol hydrochloride, glucose, and sodium bisulfite in the aseptic operating room, stir and dissolve with 3600ml water for injection; adjust the mixed solution with citric acid-sodium citrate When the pH value reaches 4.8-5.5, add 400ml of water for injection. Add activated charcoal for needles, stir, let stand for 20 minutes, decarburize by filtering with 0.45 μm and 0.22 μm filter membranes sequentially, divide the sterile solution into 7ml freeze-drying bottles according to 1ml per bottle, stopper halfway, and send it to the freeze-drying box , freeze-drying (technology is the same as embodiment 1) to get finished product.
Embodiment 3
[0053] Prescription: 1000 bottles
[0054]
[0055] In the aseptic operation room, take cefoperazone sodium, tazobactam sodium, ambroxol hydrochloride, trehalose, sodium bisulfite of prescription quantity, stir and dissolve 3600ml of water for injection; adjust the mixed solution with citric acid-sodium citrate When the pH value reaches 4.8-5.5, add 400ml of water for injection. Add activated charcoal for needles, stir, let stand for 20 minutes, decarburize by filtering with 0.45 μm and 0.22 μm filter membranes sequentially, divide the sterile solution into 7ml freeze-drying bottles according to 1ml per bottle, stopper halfway, and send it to the freeze-drying box , freeze-drying (technology is the same as embodiment 1) to get finished product.
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