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A kind of composite medical dressing and preparation method thereof

A medical and collagen technology, which is applied in the field of composite medical dressings and its preparation, can solve the problems of short drug effect duration of dressings, and achieve the effects of lasting and stable performance, increasing load capacity, and strengthening binding strength

Active Publication Date: 2015-08-05
BEIJING DINGHAN HENGHAI BIOLOGICAL TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In the composite medical dressing of the prior art, the drug effect duration of the dressing is short during use

Method used

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  • A kind of composite medical dressing and preparation method thereof
  • A kind of composite medical dressing and preparation method thereof
  • A kind of composite medical dressing and preparation method thereof

Examples

Experimental program
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Effect test

preparation example Construction

[0065] In a second aspect, the present invention provides a method for preparing a composite medical dressing, with figure 1 A flowchart of the preparation method. as attached figure 1 As shown, the method includes:

[0066] Step 101, purifying the bacterial cellulose membrane until the content of bacterial endotoxin in the bacterial cellulose membrane is less than 0.25 EU / ml to obtain a purified bacterial cellulose membrane;

[0067] Step 102, preparing a collagen solution with a concentration of 0.001-0.1 g / ml;

[0068] Step 103, adding a cross-linking agent to the collagen solution to prepare a cross-linking agent-collagen solution, so that the concentration of the cross-linking agent in the cross-linking agent-collagen solution is 0.2%-2.0%;

[0069] Step 104, adding the above-mentioned purified bacterial cellulose membrane to the cross-linking agent-collagen solution;

[0070] Step 105, at a preset temperature, make the collagen protein react with the bacterial cellul...

Embodiment 1

[0091] Step a, use pure water to wash the bacterial cellulose membrane until the pH of the bacterial cellulose membrane is 5, put the bacterial cellulose membrane washed by pure water into a sodium hydroxide solution with a concentration of 0.05mol / L, and heat up to 60 -80°C, after stirring for 10 hours, the bacterial cellulose membrane was taken out, washed with pure water until the pH of the bacterial cellulose membrane was 5-6 and the content of bacterial endotoxin in the bacterial cellulose membrane was 0.25EU / ml, obtained Purified bacterial cellulose membrane.

[0092] Wherein, the bacterial cellulose membrane is a bacterial cellulose membrane fermented by at least one bacterium selected from the genus Achromobacter, and has a three-dimensional porous network structure.

[0093] Step b, adding the interstitial collagen into pure water so that the concentration of the collagen is 0.03 g / ml, and stirring until the interstitial collagen is completely dissolved to obtain a co...

Embodiment 2

[0098] Step a, use pure water to wash the bacterial cellulose membrane until the pH of the bacterial cellulose membrane is 7.5, put the bacterial cellulose membrane washed by pure water into a potassium hydroxide solution with a concentration of 0.4mol / L, and heat up to 85 ℃, after stirring for 24 hours, take out the bacterial cellulose membrane, wash with pure water until the pH of the bacterial cellulose membrane is 4 and the content of bacterial endotoxin in the bacterial cellulose membrane is less than 0.125EU / ml, the purified bacteria are obtained Cellulose film.

[0099] Wherein, the bacterial cellulose membrane is a bacterial cellulose membrane fermented by at least one bacterium selected from Rhizobium, Pseudomonas, Aerobacter, Azotobacter, and Sarcina, and has a three-dimensional porous network structure.

[0100] Step b. Add the fibroblast collagen into pure water so that the concentration of the fibrous collagen is 0.045g / ml, and stir until the fibrous collagen is ...

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Abstract

The invention discloses a compound medical dressing and a preparation method thereof, belonging to the field of compound medical dressings. The compound medical dressing comprises bacterial cellulose membranes, collagens and crosslinking agents, wherein the collagens are crosslinked on the bacterial cellulose membranes via the crosslinking agents. The preparation method comprises the steps of adding the purified bacterial cellulose membranes to a collagen solution containing the crosslinking agents and enabling the bacterial cellulose membranes and the collagens to carry out crosslinking reaction, thus obtaining the compound medical dressing. The loads of the collagens on the bacterial cellulose membranes and the loading stability of the collagens are improved by using the crosslinking agents, so that the properties of the prepared compound medical dressing are more lasting and stable. The method is simple, is easy to operate and has relatively high practicability.

Description

technical field [0001] The invention relates to the field of medical dressings, in particular to a composite medical dressing and a preparation method thereof. Background technique [0002] Medical dressing is a medical product used to cover burns, wounds, ulcers and other wounds. Its function is to control the evaporation of wound exudate, provide a moist environment conducive to wound healing, and prevent the wound from being infected by bacteria. With the advancement of medical science, the demand for medical dressings is more and more extensive, and it is necessary to provide a medical dressing and a preparation method thereof. [0003] In the prior art, a bacterial cellulose membrane / collagen composite medical dressing is obtained by applying a collagen solution to the surface of a purified bacterial cellulose membrane and drying it. In the prepared bacterial cellulose / collagen composite medical dressing, collagen is attached to the surface of the bacterial cellulose f...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/32A61L15/28C08J3/24
Inventor 费浩刘辉石凌锋闫瑞国张香春
Owner BEIJING DINGHAN HENGHAI BIOLOGICAL TECH DEV
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