A method of improving the solubility of hydrogen in water and its application

Abstract

The invention discloses a method for raising water solubility of hydrogen, comprising the following steps: putting water into an aluminium bag and pretreating at 4 DEG C at the pressure of 0.4-0.8 Mpa for 6-7h; continuously blowing pure hydrogen prepared by electrolysis of water at 4 DEG C at the pressure of 0.4Mpa into water to dissolve for 2-3h; carrying out ultrasonic treatment on the above solution at 4 DEG C at pressure of 0.2Mpa under the condition of 10-30 thousands Hertz for 2-4h; and finally storing the hydrogen-containing solution at low temperature of 1-4 DEG C. When the above hydrogen-containing solution is applied on the surface of the skin, an aqueous solution containing hydrogen is conveyed through a conveyer pipe to the surface of the skin, hydrogen enters the skin through a biological membrane of the conveyer pipe, and the aqueous solution is recycled after outputted by the conveyer pipe. According to the hydrogen-containing solution, the aqueous solution is recycled but never enters human body. Thus, metabolism of patients is greatly reduced. The hydrogen-containing solution is especially suitable for disabled patients with lower limb ischemia reperfusion injury. By the preparation method, solubility of hydrogen can be greatly raised, and the effect of treating lower limb ischemia reperfusion injury is significant.

Description

technical field [0001] The invention relates to a method for preparing a special gas and its application, in particular to a method for increasing the solubility of hydrogen in water and its application, belonging to the medical and health field. Background technique [0002] Ischemia-reperfusion acts as a kind of oxygen stress, causing the outbreak of inflammatory response and even the disturbance of internal environment. Limb ischemia-reperfusion can activate neutrophils, produce a large number of oxygen free radicals and inflammatory mediators, put the body in a state of systemic inflammatory response, and cause multiple organ damage; with the extension of limb ischemia time, tissues consume a large amount of ATP, A large number of oxygen free radicals and lipid peroxides are produced, which can damage microvascular endothelial cells and form microcirculation embolism; reperfusion increases vascular permeability, and a large amount of liquid penetrates into the interstiti...

AI Technical Summary

Problems solved by technology

In July 2007, OhsawaI et al. reported in "Natural Medicine" that animals breathing 2% hydrogen can effectively scavenge free radicals and significantly improve cerebral ischemia-reperfusion injury. They used chemical reactions, cytology and other means to prove that hydrogen dissolved in Hydroxyl free radicals and nitrite anions can be selectively neutralized in the liquid, and the latter two are the most important mediators of oxidative damage. At present, no endogenous specific clearance pathways have been found in the body. Therefore, it is believed that hydrogen can treat cerebral ischemia-reperfusion injury The basis is selective antioxidant action

[0004] Although existing studies have shown that hydrogen is effective in the treatment of cerebral ischemia-reperfusion injury and tissue damage and organ disorders caused by reperfusion, the solubility of hydrogen in solutions such as water or normal saline is very low, even if it is supersaturated state, the solubility is only about 0.6mmol / L, and patients need to take orally or inject a large amount of hydrogen-containing solution to achieve the expected therapeutic effect; although a large amount of solution has no toxic side effects on the patient's body, it is bound to pass through the body's metabolic system through urine It is extremely inconvenient for patients with injuries; and injections such as normal saline and glucose will also increase the osmotic pressure of human body fluids, and it takes a long time for metabolism to return to normal

Although hydrogen can be dissolved in solutions such as water, the hydrogen in the supersaturated hydrogen solution at normal temperature and pressure is very easy to escape into the air and cause losses. Therefore, a special delivery device is required to transport the hydrogen-containing solution without affecting the hydrogen. Solubility can also effectively prevent hydrogen from escaping

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