Calcium phosphate bone repair material and preparation method thereof
What is Al technical title?
Al technical title is built by PatSnap Al team. It summarizes the technical point description of the patent document.
A repair material, calcium phosphate technology, applied in medical science, prosthesis, etc., can solve the problems of low strength, slow curing, poor water resistance, etc.
Inactive Publication Date: 2014-08-06
CHANGZHOU UNIV
View PDF3 Cites 10 Cited by
Summary
Abstract
Description
Claims
Application Information
AI Technical Summary
This helps you quickly interpret patents by identifying the three key elements:
Problems solved by technology
Method used
Benefits of technology
Problems solved by technology
However, there are also disadvantages such as low strength, slow curing, poor water resistance, and low degradation rate, which affect its clinical application.
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more
Examples
Experimental program
Comparison scheme
Effect test
example 1
[0009] 1. Prepare the reaction solution for preparing active calcium phosphate: 12mL concentrated phosphoric acid+3mL water+6g sodium bicarbonate
[0010] 2. Mix 2.47g of calcium hydroxide and 3mL of the reaction solution, mix well and heat in an 800W microwave oven for 5 minutes
[0011] 3. Grinding the obtained active calcium phosphate solid to form a powder, the main body of which is dehydrated calcium hydrogen phosphate
[0012] 4. Mix the obtained active calcium phosphate solid powder and tetracalcium phosphate in a ratio of 1:1, then add a certain amount of liquid phase solution to form a self-curable cement paste
example 2
[0014] 1. Prepare the reaction solution for preparing active calcium phosphate: 12mL concentrated phosphoric acid+3mL water+6g sodium bicarbonate
[0015] 2. Mix 4g of calcium hydroxide, 3mL of reaction liquid and 2ml of water, mix well and heat in 800W microwave oven for 5 minutes
[0016] 3. Grinding the obtained active calcium phosphate solid to form a powder, the main body of which is hydroxyapatite
[0017] 4. Mix the obtained active calcium phosphate solid powder and tetracalcium phosphate in a ratio of 1:1, then add a certain amount of liquid phase solution to form a self-curable cement paste
example 3
[0019] 1. Prepare the reaction solution for preparing active calcium phosphate: 12mL concentrated phosphoric acid+3mL water+4g sodium bicarbonate
[0020] 2. Mix 2g of calcium hydroxide, 0.4g of magnesium hydroxide, 3mL of reaction solution and 1mL of water, mix well and heat in a 800W microwave oven for 5 minutes
[0021] 3. Grinding the obtained active calcium-metaphosphate-containing solid to form a powder, the main body of which is amorphous calcium-magnesium phosphate
[0022] 4. Mix the obtained active calcium phosphate solid powder and tetracalcium phosphate in a ratio of 1:1, then add a certain amount of liquid phase solution to form a self-curable cement paste
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
PUM
Login to view more
Abstract
The invention relates to a calcium phosphate bone repair material and a preparation method thereof. The calcium phosphate bone repair material is formed by mixing a solid phase with a liquid phase, wherein the solid phase comprises tetracalcium phosphate or monocalcium phosphate monohydrate and active calcium phosphate auxiliarily prepared under the support of microwaves; and the liquid phase is any one or more than one of the following liquid materials: distilled water, normal saline, simulated body fluid, dihydrogen phosphate solution, hydrogen phosphate solution, phosphate buffer solution, bicarbonate solution and citric acid solution. The preparation method comprises a step of preparing active calcium phosphate under the support of microwaves; a step of uniformly mixing active calcium phosphate with tetracalcium phosphate or monocalcium phosphate monohydrate to prepare a solid phase; a step of preparing a liquid phase; and a compounding step of rapidly mixing the solid-phase ingredients with the liquid-phase solution and uniformly stirring to obtain the calcium phosphate bone repair material. The calcium phosphate bone repair material disclosed by the invention is remarkably improved in terms of mechanical properties, brittleness, setting time and degradation property, has good biocompatibility, is injectable, and capable of being used for bone tissue damage repair.
Description
technical field [0001] The invention relates to the technical field of medical biomaterials, in particular to a calcium phosphate bone repair material and a preparation method thereof technical background [0002] At present, the commonly used bone repair materials include autologous bone, allogeneic bone and artificial synthetic materials, but these materials are deficient to varying degrees and cannot meet clinical needs. For example, although autologous bone transplantation has no immune rejection and has a good repair effect, the material obtained is very limited and causes bone defects in the donor site; allogeneic bone transplantation is likely to cause immune rejection, poor repair effect, and the risk of infectious viral diseases ; Synthetic materials such as polymethyl methacrylate, vulcanized silicone rubber, etc. are non-degradable materials and cannot repair the defect area. [0003] Brown and Chow of the United States discovered the hydration and hardening prop...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
Application Information
Patent Timeline
Application Date:The date an application was filed.
Publication Date:The date a patent or application was officially published.
First Publication Date:The earliest publication date of a patent with the same application number.
Issue Date:Publication date of the patent grant document.
PCT Entry Date:The Entry date of PCT National Phase.
Estimated Expiry Date:The statutory expiry date of a patent right according to the Patent Law, and it is the longest term of protection that the patent right can achieve without the termination of the patent right due to other reasons(Term extension factor has been taken into account ).
Invalid Date:Actual expiry date is based on effective date or publication date of legal transaction data of invalid patent.