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Preparation method and application of star polymer

A star-shaped polymer, polymer technology, applied in chemical instruments and methods, chemicals for biological control, disinfectants, etc., can solve problems that are rarely discovered

Active Publication Date: 2016-08-24
UNIV OF SCI & TECH OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, in the fight against pathogenic bacteria, such multifunctional systems have rarely been discovered so far.

Method used

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  • Preparation method and application of star polymer
  • Preparation method and application of star polymer
  • Preparation method and application of star polymer

Examples

Experimental program
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Effect test

preparation example 1

[0064] In the first step, the following cationic amphiphilic linear copolymer L1 is prepared:

[0065]

[0066] It is characterized in that: while the end group is an alkynyl group, it contains a positively charged tertiary amine monomer, a hydrophobic long alkyl chain monomer, and a glycidyl ester monomer that can be modified by sodium azide.

[0067] Preparation method: use polydentate nitrogen ligand and transition metal halide as catalyst, propynyl bromoisobutyrate as initiator, dimethylaminoethyl methacrylate, n-butyl methacrylate, shrink methacrylate Glyceride is a monomer, undergoing atom transfer radical random copolymerization. Proynyl bromoisobutyrate (25mg, 0.13mmol), dimethylaminoethyl methacrylate (1.63g, 10.4mmol), n-butyl methacrylate (0.08g, 0.56mmol), glycidyl methacrylate Esters (50mg, 0.35mmol), pentamethyldiethylenetriamine (41mg, 0.23mmol) were dissolved in anisole (2mL), fully degassed and equilibrated at 40°C for 10 minutes, then cuprous bromide (16m...

preparation example 2

[0077] In the first step, the following amphiphilic linear copolymer L2 is prepared:

[0078]

[0079] It is characterized in that: while the end group is an alkynyl group, it contains a positively charged tertiary amine monomer, a hydrophobic long alkyl chain monomer, and a glycidyl ester monomer that can be modified by sodium azide.

[0080] Preparation method: similar to the preparation method in Preparation Example 1, adjusting the feed ratio of monomers participating in atom transfer radical polymerization (ATRP). Dissolve propynyl bromoisobutyrate, dimethylaminoethyl methacrylate, n-butyl methacrylate, glycidyl methacrylate, and pentamethyldiethylenetriamine in anisole in turn. After degassing, equilibrate at 40°C for 10 minutes, then quickly add cuprous bromide. After 4 hours, the polymerization was terminated, the metal salt catalyst was removed, concentrated, and precipitated three times in diethyl ether. Obtain white solid product (0.54g, productive rate~40% aft...

preparation example 3

[0086] In the first step, the following linear copolymer L3 is prepared:

[0087]

[0088] It is characterized in that: while the end group is an alkynyl group, it contains a positively charged tertiary amine monomer and a glycidyl ester monomer that can be modified by sodium azide.

[0089] Preparation method: similar to the preparation method in Preparation Example 1, adjusting the feed ratio of monomers participating in atom transfer radical polymerization (ATRP). Propynyl bromoisobutyrate, dimethylaminoethyl methacrylate, glycidyl methacrylate, and pentamethyldiethylenetriamine were dissolved in anisole in turn for atom transfer radical polymerization (ATRP) . After 4 hours, the polymerization was terminated, and the metal salt catalyst was removed, followed by concentration and precipitation. Obtain white solid product (0.68g, productive rate~52% after vacuum drying; The GPC test result with tetrahydrofuran as mobile phase is: number average molecular weight M n =3....

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Abstract

The invention relates to a novel preparation method and application of a cationic amphiphilic tetra-armed star polymer. In particular, the star polymer can be obtained through synthetic means such as atom transfer radical polymerization (ATRP) and click chemistry. A core of the star polymer is tetraphenylethylene with the characteristic of aggregation-induced emission. A polymer linear arm is a cationic amphiphilic random copolymer with excellent antibacterial effects. A covalently labeled T1 type magnetic resonance (MR) contrast agent is an organic gadolinium chelate. By using the cationic amphiphilic tetra-armed star polymer, fluorescence / MR double quantitative detection of Gram positive and negative bacteria with negative charges on the surfaces in the environment of pure water is achieved, and meanwhile good antibacterial effects are gained.

Description

technical field [0001] The present invention relates to the preparation and application of star polymers, more specifically, to the preparation and application of a cationic amphiphilic four-arm star polymer. Background technique [0002] Infectious diseases, especially infections caused by pathogenic bacteria, are currently one of the main causes of human death worldwide (Anthony S. Fauci, et al. N. Engl. J. Med. 2012, 366, 454-461). The development of new materials or methods for rapid and efficient bacterial detection and antibacterial is an effective way to meet this challenge. On the one hand, although the bacterial detection methods based on plate culture, immunoassay, and electrochemistry have their own advantages, they are often accompanied by disadvantages such as long analysis time, complicated experimental operations, and high cost (F.Javier Del Campo, et al. Biosens. Bioelectron. 2007, 22, 1205-1217). However, whole-cell bacterial detection methods based on mag...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F293/00C08F8/44C09K11/06A01P1/00
Inventor 刘世勇李亚民
Owner UNIV OF SCI & TECH OF CHINA
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