A kind of pharmaceutical composition for treating insomnia and its application
A technology for insomnia and drugs, applied in the field of medicine, can solve problems such as toxic side effects and adverse reactions, and achieve the effects of reducing the time and frequency of awakening, shortening the time of falling asleep, and inhibiting respiration
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Embodiment 1
[0021] Example 1 Experimental Research on the Influence of Prosteatin from Violet Flower on the Number of Autonomous Activities in Mice
[0022] Kunming mice, SPF grade, half male and half male, body weight 18-22g. 30 mice were taken, and after being adaptively fed for 3 days, they were randomly divided into blank control group, positive control group (Valantia tablet 5 mg / kg / d), and proglutinin group (20 mg / kg / d). The mice were administered intragastrically once a day for 5 consecutive days, and the blank control group was given an equal volume of normal saline. One hour after the last administration, the mice were placed in the mouse autonomic activity recorder for 5 minutes, and then the number of activities and the number of standing of the mice within 5 minutes were measured.
[0023] According to the test result of table 1, it can be seen that the positive control group and the prostegoglutinin group can significantly reduce the number of activities and the number of s...
Embodiment 2
[0027] Example 2 Experimental Study on the Effects of Prosteosinogenin Viola on Sleep Time of Mice Induced by Threshold Dose of Pentobarbital Sodium
[0028] Kunming mice, SPF grade, half male and half male, body weight 18-22g. Mice sedation and hypnosis experiment 30 mice were taken, and after adaptive feeding for 3 days, they were randomly divided into blank control group, positive control group (Valantia tablets 5 mg / kg / d), and prostegoglutinin group (20 mg / kg / d). Mice were administered intragastrically once a day for 6 consecutive days, and the blank group was given an equal volume of normal saline. One hour after the last administration, each mouse was intraperitoneally injected with pentobarbital sodium 40 mg / kg. The disappearance of righting reflex of mice after injection was used as the indicator of human sleep in each group, and the recovery of righting reflex of mice was used as the indicator of awakening. sleep latency and sleep duration.
[0029] According to t...
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