A kind of tripterygium wilfordii film preparation for treating rheumatoid arthritis and its preparation method
A rheumatoid and tripterygium wilfordii technology, applied in the field of traditional Chinese medicine transdermal drug delivery preparations, can solve problems such as no film coating agent, and achieve the effects of good penetration effect, cost reduction and easy penetration
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Embodiment 1
[0035] The preparation of embodiment 1 Tripterygium wilfordii film-coating agent
[0036] The proportion of each material is as follows:
[0037] Tripterygium wilfordii extract 1g Polyvinyl alcohol 124 5g Propylene Glycol 2g ethanol 25g
[0038] Triethanolamine 0.7g Add distilled water to 100g
[0039] Preparation:
[0040] Weigh polyvinyl alcohol 124 according to the prescription amount, make it 10% concentration with distilled water, seal it, soak it in cold water for 12 hours, swell it in a water bath at 80°C for 2 hours, take it out and let it cool for later use. Add the prescribed amount of propylene glycol solution to the polyvinyl alcohol 124 solution under stirring, and stir evenly. Dissolve the prescription amount of Tripterygium wilfordii extract in the prescription amount of ethanol, slowly add it to the above matrix, and stir while adding to prevent the precipitation of polyvinyl alcohol 124. Finally, add dist...
Embodiment 2
[0041] The preparation of embodiment 2 Tripterygium wilfordii film-coating agent
[0042] The proportion of each material is as follows:
[0043] Tripterygium wilfordii extract 0.5g Polyvinyl alcohol 1788 10g Glycerol 6g ethanol 16g ammonia 0.5g Add distilled water to 100g
[0044] Preparation:
[0045] Weigh polyvinyl alcohol 1788 according to the prescription amount, make it 20% concentration with distilled water, seal it, soak it in cold water for 18 hours, swell it in a water bath at 80°C for 3 hours, take it out and let it cool for later use. Add the prescribed amount of glycerin solution to the polyvinyl alcohol 1788 solution under stirring, and stir evenly. Dissolve the prescription amount of Tripterygium wilfordii extract in the prescription amount of ethanol, slowly add it to the above matrix, and stir while adding to prevent the precipitation of polyvinyl alcohol 1788. Finally, add distilled water to a sufficient amount...
Embodiment 3
[0046] The preparation of embodiment 3 Tripterygium wilfordii film-coating agent
[0047] The proportion of each material is as follows:
[0048] Tripterygium wilfordii extract 1.5g Carbomer 940 0.1g Diethyl phthalate 4g ethanol 20g
[0049] Sodium citrate 0.3g Add distilled water to 100g
[0050] Preparation:
[0051] Weigh the carbomer according to the prescription amount, make it into 0.2% concentration with distilled water, seal it, soak it in cold water for 12 hours, swell it in a water bath at 90°C for 2 hours, take it out and let it cool for later use. Add the prescribed amount of diethyl phthalate solution to the carbomer solution under stirring, and stir evenly. Dissolve the prescription amount of Tripterygium wilfordii extract in the prescription amount of ethanol, slowly add it to the above matrix, and stir while adding. Finally, distilled water was added to a sufficient amount, and the pH was adjusted to 8 w...
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