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Vecuronium bromide pharmaceutical composition for injection and preparation method thereof

A technology of vecuronium bromide and a composition, applied in the field of medicine, can solve the problems of hidden safety hazards, high production cost, lactose intolerance and the like, and achieves the advantages of good safety, simple prescription and avoiding the phenomenon of lactose intolerance. Effect

Active Publication Date: 2014-06-25
CHENGDU EASTON BIOPHARMACEUTICALS CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are many types of excipients in this prescription, and the production cost is high; in addition, lactose is used as an excipient in the prescription, but as we all know, each person’s constitution is different, and sometimes severe lactose intolerance will occur, and lactose It is an excipient of animal origin, which may come from the milk of animals suffering from mad cow disease and other diseases. It is a safety hazard when used in pharmaceuticals, especially injection administration

Method used

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  • Vecuronium bromide pharmaceutical composition for injection and preparation method thereof
  • Vecuronium bromide pharmaceutical composition for injection and preparation method thereof
  • Vecuronium bromide pharmaceutical composition for injection and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0045] Embodiment 1 Vecuronium Bromide Prescription for Injection (in 1000 bottles, unit: g)

[0046] Vecuronium Bromide

[0047] Preparation process: Inject 500ml of water for injection into the liquid mixing tank, add 10g of citric acid, 8g of disodium hydrogen phosphate, and 2g of vecuronium bromide, heat to 50°C, stir until dissolved; add 0.1% (w / v) needle Use activated carbon, stir well, keep warm and adsorb for about 15 minutes, stir 2 to 3 times during this period, then filter for decarbonization, add water for injection to the full amount, and stir well; after fine filtration and clarification, conduct semi-finished product inspection, use phosphoric acid solution or Adjust the pH value with sodium solution, control the pH value at 3.8, measure the content of the solution, and fill it into a vial; freeze-dry after checking the difference in filling volume and clarity; capping and sealing; packaging. Example 2 Prescription of Vecuronium Bromide for Injection (...

Embodiment 8

[0060] Vecuronium Bromide

[0061] Preparation process: Inject 500ml of water for injection into the liquid mixing tank, add 14g of citric acid, 11g of disodium hydrogen phosphate, and 3g of vecuronium bromide, heat to 50°C, stir until dissolved; add 0.1% (w / v) needle Use activated carbon, stir well, keep warm and adsorb for about 15 minutes, stir 2 to 3 times during this period, then filter for decarbonization, add water for injection to the full amount, and stir well; Adjust the pH value with sodium solution, control the pH value at 4.2, measure the content of the solution, and fill it into a vial; freeze-dry after checking the difference in filling volume and clarity; capping and sealing; packaging. Example 9 Prescription of Vecuronium Bromide for Injection (in 1000 bottles, unit: g)

[0062] Vecuronium Bromide

[0063] Preparation process: Inject 500ml of water for injection into the liquid mixing tank, add 10g of citric acid, 8g of disodium hydrogen ph...

Embodiment 12

[0068] Vecuronium Bromide

[0069] Preparation process: Inject 500ml of water for injection into the liquid mixing tank, add 14g of citric acid, 11g of disodium hydrogen phosphate, 4g of vecuronium bromide, heat to 50°C, stir until dissolved; add 0.1% (w / v) needle Use activated carbon, stir well, keep warm and adsorb for about 15 minutes, stir 2 to 3 times during this period, then filter for decarbonization, add water for injection to the full amount, and stir well; Adjust the pH value with sodium solution, control the pH value at 4.1, measure the content of the solution, and fill it into a vial; freeze-dry after checking the difference in filling volume and clarity; capping and sealing; packaging. Example 13 Prescription of Vecuronium Bromide for Injection (in 1000 bottles, unit: g)

[0070] Vecuronium Bromide

[0071] Preparation process: Inject 500ml of water for injection into the liquid mixing tank, add 16g of citric acid, 12g of disodium hydrogen phos...

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Abstract

The invention relates to a vecuronium bromide pharmaceutical composition for injection and a preparation method thereof. The vecuronium bromide pharmaceutical composition is characterized in that the pharmaceutical composition consists of vecuronium bromide, citric acid and disodium hydrogen phosphate. In the prescription of the vecuronium bromide pharmaceutical composition, amino acid, lactose, and the like are not used as excipients, so that a risk that the amino acid possibly reacts with the main drug is lowered, and safety risk caused by adding lactose is eliminated at the same time, and therefore, safety is better; and moreover, technical prejudice that product outline is kept by adding excipients such as mannitol, and the like in the prior art are overcome. The vecuronium bromide pharmaceutical composition disclosed by the invention is simple in prescription, lowers production cost to a certain extent, and is more suitable for industrial production.

Description

technical field [0001] The invention relates to a pharmaceutical composition for injection and a preparation process thereof, in particular to a pharmaceutical composition of vecuronium bromide for injection and a preparation method thereof, belonging to the technical field of medicine. Background technique [0002] The English name of vecuronium bromide is Vecuronim Bromide, and its molecular formula is C 34 h 57 BrN 2 o 4 , the structural formula is: [0003] [0004] Vecuronium bromide is a moderate-effect non-depolarizing muscle relaxant of monoquaternary ammonium steroids, which blocks the transmission between nerve endings and striated muscles by competing with acetylcholine for nicotinic receptors located on the motor endplates of striated muscles. Unlike depolarizing neuromuscular blocking drugs, such as succinylcholine, this product does not cause muscle fiber fasciculation and does not block the vagus nerve. Because vecuronium bromide does not cause rapid h...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/19A61K31/58A61K47/12A61K47/02
Inventor 王颖
Owner CHENGDU EASTON BIOPHARMACEUTICALS CO LTD
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