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Compound risperidone subcutaneous embedded sustained-release preparation and preparation method thereof

A technology of compound risperidone and risperidone, applied in the field of antipsychotic medical drugs, can solve the problems of intractable remission, recurrent disease, and poor compliance of patients with maintenance treatment, and achieve maintenance treatment, lasting curative effect, and effective blood drug concentration. Effect

Inactive Publication Date: 2014-06-25
郑玉华 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to disease, economic conditions, long time course and other reasons, the patient's maintenance treatment compliance is poor, and the patient often takes the initiative to interrupt the drug in a short period of time, causing the disease to recur, or even a persistent state that is difficult to relieve

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] A compound risperidone subcutaneously implanted sustained-release agent, which is made of raw materials including the following weight (gram): risperidone 100, propionic acid controlled release agent 0.00247; after risperidone and propionic acid controlled release agent are uniformly mixed It is made into granules and wrapped in multiple medical silicone tubes.

[0020] The preparation method of the compound risperidone subcutaneously implanted sustained-release agent of this embodiment includes the following steps:

[0021] 1) Preparation of raw materials: confirm the quality of multiple medical silicone tubes, risperidone, propionic acid controlled release agent, and medical adhesives, and perform necessary disinfection treatment;

[0022] 2) Compound medicine preparation: In order to mix risperidone and propionic acid controlled release agent fully and uniformly, put 100 grams of risperidone and 0.00247 grams of propionic acid into the container, and then add disinfectant, ...

Embodiment 2

[0030] A compound risperidone subcutaneous implanted sustained-release agent, which is made of raw materials including the following weight (grams): risperidone 1000, propionic acid controlled release agent 0.0247; after risperidone and propionic acid controlled release agent are uniformly mixed It is made into granules and wrapped in multiple medical silicone tubes.

[0031] The preparation method of the compound risperidone subcutaneously implanted sustained-release agent of this example is the same as that of Example 1.

Embodiment 3

[0033] A compound risperidone subcutaneously implanted sustained-release agent, which is made of raw materials including the following weight (grams): risperidone 10000, propionic acid controlled release agent 0.247; after mixing risperidone and propionic acid controlled release agent uniformly It is made into granules and wrapped in multiple medical silicone tubes.

[0034] The preparation method of the compound risperidone subcutaneously implanted sustained-release agent of this example is the same as that of Example 1.

[0035] The application method of the compound risperidone subcutaneously implanted sustained-release agent of the present invention: suitable patients, take the lower abdominal wall and subcutaneously implant, according to the dosage requirements, 8-10 pieces of the patented preparation for each patient are used once a year.

[0036] The medical silica gel film for the compound risperidone subcutaneously implanted sustained-release agent of the present invention i...

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Abstract

The invention relates to a compound risperidone subcutaneous embedded sustained-release preparation and a preparation method thereof. The sustained-release preparation is prepared from the following raw materials in parts by weight: 100 parts of risperidone and 0.00247 part of propionic acid sustained-release preparation. The preparation method comprises the following step of uniformly mixing risperidone and the propionic acid sustained-release preparation into granules which are wrapped in a plurality of medical silicon rubber tubes. The compound risperidone subcutaneous embedded sustained-release preparation provided by the invention can be guided and embedded in a loose part of the subcutaneous tissue of the inferior abdominal wall of a patient by means of a small incision with a sleeve needle after getting a satisfactory effect of acute treatment of the patient, and 8-10 subcutaneous embedded sustained-release preparations can be embedded at one time. The subcutaneous embedded sustained-release preparation is lasting in curative effect and economical and practical, and the one-time embedding curative effect is controlled within about 1 year. Medicines guided by the sustained-release preparation are slowly and uniformly released through a medical silica gel thin film wall to ensure stable and effective blood concentration so as to realize the purpose of maintaining treatment. The subcutaneous embedded sustained-release preparation provided by the invention is suitable for patients with various schizophrenia, mood disorders, multiple Tourette syndrome and other risperidone treatment indications.

Description

Technical field [0001] The invention relates to the technical field of antipsychotic medical drugs, in particular to a compound risperidone subcutaneously implanted sustained-release agent and a preparation method thereof. Background technique [0002] In the field of psychiatric medicine, schizophrenia, mood disorders, and multiple tic- Tourette syndrome are all chronic mental illnesses, which are characterized by recurring episodes and even lifelong illnesses. At present, these diseases are mainly treated with various psychotropic drugs. According to the diagnosis and treatment routine, after the acute treatment period, in order to achieve the purpose of consolidating the curative effect and preventing recurrence, it is necessary to maintain long-term medication. Due to diseases, economic conditions, long duration and other reasons, patients have poor compliance with maintenance treatment. Patients often take the initiative to stop medication in a short period of time, causing...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K31/519A61K47/12A61K47/04A61P25/18
Inventor 郑士全
Owner 郑玉华
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