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Antibacterial nano emulsion of Chinese herbal medicine composition and preparation method thereof

A technology of Chinese herbal medicine composition and nanoemulsion, which is applied in the direction of pharmaceutical formulations, antifungal agents, antibacterial drugs, etc., can solve the problems of few types of antibacterial products, late antibacterial materials and supplies, and cannot meet the needs of the market. Antibacterial properties, increased broad-spectrum antibacterial properties, and high bactericidal efficiency

Active Publication Date: 2014-06-18
KARLIE COSMETICS MFG CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The research and development of antibacterial materials and supplies in my country started relatively late, and there are still relatively few varieties of antibacterial products. Many products are in the market introduction period and are far from meeting the needs of the market.

Method used

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  • Antibacterial nano emulsion of Chinese herbal medicine composition and preparation method thereof
  • Antibacterial nano emulsion of Chinese herbal medicine composition and preparation method thereof
  • Antibacterial nano emulsion of Chinese herbal medicine composition and preparation method thereof

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preparation example Construction

[0030] The preparation method of Chinese herbal medicine composition antibacterial nanoemulsion of the present invention comprises the following steps:

[0031] 1) Mix 0.01%-10% Chinese herbal medicine composition, 0.05%-20% non-ionic surfactant and 1%-30% polyol at 50-70°C and stir evenly at a speed of 200-1000rmp;

[0032] 2) Stir at a speed of 200-1000rmp, slowly add water at 50-70°C to step 1) until it becomes transparent, then lower the temperature to a constant temperature of 30-40°C;

[0033] 3) Stir at a speed of 200-1000rmp, slowly add deionized water at 30-40°C to step 2) until the remaining weight of water is added, and the antibacterial nanoemulsion of the Chinese herbal medicine composition described in Requirement 1 can be obtained .

[0034] The preparation method of Chinese herbal medicine composition antibacterial nanoemulsion of the present invention comprises the following steps:

[0035] 1) Mix 0.01%-10% Chinese herbal medicine composition, 0.05%-20% non-...

Embodiment 1

[0039] Embodiment 1, antibacterial and bactericidal experiments of Chinese herbal medicine composition:

[0040] (1) The test sample is a Chinese herbal medicine composition, and the Chinese herbal medicine composition is: artesunolactone, 3-butenylphthalide, cinnamaldehyde, 4-coumaric acid, cressane lactone, dehydrocresinolide A mixture of at least two components of esters and eugenol.

[0041] (2) Strains:

[0042] Escherichia coli, Staphylococcus aureus, Candida albicans.

[0043] (3) Medium:

[0044] 1) Bacterial culture medium: nutrient broth medium, nutrient broth agar medium.

[0045] 2) Fungal culture medium: sandcastle liquid medium, sandcastle agar medium.

[0046] (4) Steps of antibacterial test method:

[0047] 1) Prepare the required medium according to the formula, then sterilize, prepare and reserve;

[0048] 2) Activate the required strains;

[0049]4) Use the activated bacteria to make a standard curve of bacterial concentration (measure OD600 live colo...

Embodiment 2

[0088] Embodiment 2, the preparation of Chinese herbal medicine composition antibacterial nanoemulsion:

[0089] In this embodiment, the Chinese herbal medicine composition is a mixture of artemisinin and eugenol, the ratio is 1:1, and the preparation method of antibacterial nanoemulsion is as follows:

[0090] 1) Mix 0.5% Chinese herbal medicine composition, 1% polyoxyethylene sorbitan monooleate and 4% glycerin at 60°C and stir evenly at a speed of 400rmp;

[0091] 2) Stir at a speed of 400rmp, slowly add water at 60°C to step 1) until it becomes transparent, then lower the temperature to a constant temperature of 30°C;

[0092] 3) Stir at a speed of 200rmp, slowly add deionized water at 30°C to step 2) until the remaining weight of water is added, and the antibacterial nanoemulsion of the Chinese herbal medicine composition can be obtained, and the particle size is 68nm after the laser particle size analyzer test . Embodiment 3, the preparation of Chinese herbal medicine ...

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Abstract

The invention discloses an antibacterial nano emulsion of a Chinese herbal medicine composition and a preparation method thereof. The Chinese herbal medicine composition comprises at least two of ligustilide, 3-butylidenephthalide, cinnamyl aldehyde, 4-cumaric acid, costunolide, dehydrocostus lactone and eugenol, and the antibacterial nano emulsion is prepared from the Chinese herbal medicine composition. In the manner, the Chinese herbal medicine composition provided by the invention is from natural Chinese herbal medicines, and is small in toxic and side effect, the antibacterial spectrum property of the Chinese herbal medicine composition is increased by synergistic interaction of combination, and the antibacterial nano emulsion can be effectively used for preparing medicaments or cosmetics for treating or relieving escherichia coli, staphylococcus aureus, candida albicans and the like. The antibacterial nano emulsion disclosed by the invention is simple in preparation method, and can be applied to the medicaments or cosmetics at a large scale.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to an antibacterial nanoemulsion of a Chinese herbal medicine composition and a preparation method thereof. Background technique [0002] Antibacterial agents refer to various preparations that can kill or inhibit the activity of microorganisms within a certain period of time. They are chemical substances that are highly sensitive to microorganisms such as bacteria and molds. The research and development of antibacterial agents began in the early 1980s. According to the chemical composition of antibacterial agents, they can be divided into three categories: inorganic antibacterial agents, organic antibacterial agents and composite antibacterial agents. With the development of the times and the advancement of science and technology, textiles, hygiene products, food packaging, medical materials and other fields that are closely related to people's live...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/365A61K9/107A61K8/06A61K8/49A61K8/34A61P31/04A61P31/10A61Q19/00A61K31/11A61K31/192A61K31/085
CPCY02A50/30
Inventor 周华锋段明星高杨姜梅严泽民徐之伟
Owner KARLIE COSMETICS MFG CO LTD
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